{"id":"https://openalex.org/W1987366735","doi":"https://doi.org/10.1016/s0264-410x(99)00233-9","title":"Principles of transcutaneous immunization using cholera toxin as an adjuvant","display_name":"Principles of transcutaneous immunization using cholera toxin as an adjuvant","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1987366735","doi":"https://doi.org/10.1016/s0264-410x(99)00233-9","mag":"1987366735","pmid":"https://pubmed.ncbi.nlm.nih.gov/10506407"},"language":"en","primary_location":{"id":"doi:10.1016/s0264-410x(99)00233-9","doi":"https://doi.org/10.1016/s0264-410x(99)00233-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0264-410x(99)00233-9","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077989864","display_name":"Tanya Scharton\u2010Kersten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tanya Scharton-Kersten","raw_affiliation_strings":["Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA. tskersten@iomai.com","IOMAI Corporation, Washington, DC 20037, USA","Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA. tskersten@iomai.com","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"IOMAI Corporation, Washington, DC 20037, USA","institution_ids":[]},{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Glenn","raw_affiliation_strings":["IOMAI Corporation, Washington, DC 20037, USA","Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Washington, DC 20037, USA","institution_ids":[]},{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078188740","display_name":"Russell A. Vassell","orcid":"https://orcid.org/0000-0002-2295-5890","observed_orcids":["https://orcid.org/0000-0002-2295-5890"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell Vassell","raw_affiliation_strings":["IOMAI Corporation, Washington, DC 20037, USA","Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Washington, DC 20037, USA","institution_ids":[]},{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113556137","display_name":"Jianmei Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-mei Yu","raw_affiliation_strings":["IOMAI Corporation, Washington, DC 20037, USA","Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Washington, DC 20037, USA","institution_ids":[]},{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063731891","display_name":"Deborah Walwender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Walwender","raw_affiliation_strings":["IOMAI Corporation, Washington, DC 20037, USA","Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Washington, DC 20037, USA","institution_ids":[]},{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007536314","display_name":"Carl R. Alving","orcid":"https://orcid.org/0000-0002-1913-3909","observed_orcids":["https://orcid.org/0000-0002-1913-3909"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl R. Alving","raw_affiliation_strings":["Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research, Department of Membrane Biochemistry, 14th and Dahlia Sts. NW, Building 40, Rm 3049, Washington, DC 20307, USA","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077989864"],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":4.9448,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.96134787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"S37","last_page":"S43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.22139999270439148,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcutaneous-immunization","display_name":"transcutaneous immunization","score":1.0},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.9129999876022339},{"id":"https://openalex.org/keywords/h-2-complex","display_name":"H-2 complex","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mhc-restriction","display_name":"MHC restriction","score":0.925000011920929},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hen-egg-white-lysozyme","display_name":"hen egg white lysozyme","score":0.8880000114440918},{"id":"https://openalex.org/keywords/diphtheria-toxoid","display_name":"diphtheria toxoid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ear-skin","display_name":"ear skin","score":0.40799999237060547},{"id":"https://openalex.org/keywords/vaccine-platforms","display_name":"vaccine platforms","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.8483892679214478},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.7226415276527405},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.6828044652938843},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.6192156076431274},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5970910787582397},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5941125154495239},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5312079191207886},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5095317959785461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.474005788564682},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4547996520996094},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.4443761706352234},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.42028239369392395},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.342590868473053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31031644344329834},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.27659130096435547}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004168","descriptor_name":"Diphtheria Toxoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0264-410x(99)00233-9","doi":"https://doi.org/10.1016/s0264-410x(99)00233-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0264-410x(99)00233-9","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:10506407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10506407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W39816578","https://openalex.org/W1625990430","https://openalex.org/W1874828781","https://openalex.org/W1894246118","https://openalex.org/W1972863218","https://openalex.org/W1977321009","https://openalex.org/W2051567059","https://openalex.org/W2074116901","https://openalex.org/W2087809796","https://openalex.org/W2089703019","https://openalex.org/W2095214966","https://openalex.org/W2129322668","https://openalex.org/W2172209357","https://openalex.org/W2329970616","https://openalex.org/W2331213567","https://openalex.org/W2409164684","https://openalex.org/W2410619899","https://openalex.org/W4241618705","https://openalex.org/W4313316606"],"related_works":["https://openalex.org/W4313316606","https://openalex.org/W2172209357","https://openalex.org/W2129322668","https://openalex.org/W1549346812","https://openalex.org/W1969393357","https://openalex.org/W1968395388","https://openalex.org/W2051506045","https://openalex.org/W2411087525","https://openalex.org/W101046175","https://openalex.org/W2128425898"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
