{"id":"https://openalex.org/W1987365958","doi":"https://doi.org/10.3109/07357909409021388","title":"Double Modulation of 5-Fluorouracil in the Treatment of Advanced Colorectal Carcinoma: Report of a Trial with Sequential Methotrexate, Intravenous (Loading Dose) Folinic Acid, 5-Fluorouracil, and a Literature Review","display_name":"Double Modulation of 5-Fluorouracil in the Treatment of Advanced Colorectal Carcinoma: Report of a Trial with Sequential Methotrexate, Intravenous (Loading Dose) Folinic Acid, 5-Fluorouracil, and a Literature Review","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1987365958","doi":"https://doi.org/10.3109/07357909409021388","mag":"1987365958","pmid":"https://pubmed.ncbi.nlm.nih.gov/8281461"},"language":"en","primary_location":{"id":"doi:10.3109/07357909409021388","doi":"https://doi.org/10.3109/07357909409021388","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909409021388","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110732972","display_name":"Edward P. Balaban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward P. Balaban","raw_affiliation_strings":["Department of Internal Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077989297","display_name":"Mateel Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mateel Graham","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047394954","display_name":"Steve Perkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Perkins","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109180292","display_name":"Richard G. Sheehan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Sheehan","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905079","display_name":"Eugene P. Frenkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene P. Frenkel","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology/Oncology, Simmons Cancer Center, University of Texas, Southwestern Medical Center and Department of Veterans Affairs Medical Center Dallas, Texas","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104067127","display_name":"Michael B. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126526","display_name":"Texas Health Harris Methodist Hospital Fort Worth","ror":"https://ror.org/02yrcx115","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126526","https://openalex.org/I4210163017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ross","raw_affiliation_strings":["The Harris Methodist Hospital, Fort Worth, Texas","The Harris Methodist Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Harris Methodist Hospital, Fort Worth, Texas","institution_ids":["https://openalex.org/I4210126526"]},{"raw_affiliation_string":"The Harris Methodist Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113600506","display_name":"Joan M. Bull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Bull","raw_affiliation_strings":["Division of Medical Oncology, University of Texas Health Science Center at Houston, Houston, Texas","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013258312","display_name":"Brian T. Pruitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Pruitt","raw_affiliation_strings":["Division of Medical Oncology, Texas Tech University School of Medicine Amarillo, Texas","Texas Tech University Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Texas Tech University School of Medicine Amarillo, Texas","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Texas Tech University Health Sciences Center","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111539832","display_name":"Phillip Periman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130556","display_name":"Harrington Cancer Center","ror":"https://ror.org/03ak9f780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Periman","raw_affiliation_strings":["Don and Sybil Harrington Cancer Center, Amarillo, Texas","Don and Sybil Harrington Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center, Amarillo, Texas","institution_ids":["https://openalex.org/I4210130556"]},{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center","institution_ids":["https://openalex.org/I4210130556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084116539","display_name":"Chris Ruud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130556","display_name":"Harrington Cancer Center","ror":"https://ror.org/03ak9f780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Ruud","raw_affiliation_strings":["Don and Sybil Harrington Cancer Center, Amarillo, Texas","Don and Sybil Harrington Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center, Amarillo, Texas","institution_ids":["https://openalex.org/I4210130556"]},{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center","institution_ids":["https://openalex.org/I4210130556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111845317","display_name":"James K. Luce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130556","display_name":"Harrington Cancer Center","ror":"https://ror.org/03ak9f780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Luce","raw_affiliation_strings":["Don and Sybil Harrington Cancer Center, Amarillo, Texas","Don and Sybil Harrington Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center, Amarillo, Texas","institution_ids":["https://openalex.org/I4210130556"]},{"raw_affiliation_string":"Don and Sybil Harrington Cancer Center","institution_ids":["https://openalex.org/I4210130556"]}]},{"author_position":"last","author":{"id":null,"display_name":"Texas Regional Oncology Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Texas Regional Oncology Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51643472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"12","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9829999804496765},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sequential-chemotherapy","display_name":"sequential chemotherapy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/drug-modulation","display_name":"drug modulation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cytoreductive-chemotherapy","display_name":"cytoreductive chemotherapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6690000295639038},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C2779804826","wikidata":"https://www.wikidata.org/wiki/Q45435667","display_name":"Folinic acid","level":4,"score":0.9463031888008118},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.9412481784820557},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7777401804924011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7007088661193848},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5018582344055176},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.4195241630077362},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.41719821095466614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3958323299884796},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.37495923042297363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18775507807731628}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/07357909409021388","doi":"https://doi.org/10.3109/07357909409021388","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909409021388","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},{"id":"pmid:8281461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8281461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer investigation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W126285798","https://openalex.org/W1506206575","https://openalex.org/W1837458449","https://openalex.org/W1844072307","https://openalex.org/W1847455118","https://openalex.org/W1852557879","https://openalex.org/W1863898801","https://openalex.org/W1885154202","https://openalex.org/W1916504364","https://openalex.org/W1995710185","https://openalex.org/W2012717912","https://openalex.org/W2052318889","https://openalex.org/W2104722366","https://openalex.org/W2132039541","https://openalex.org/W2167805334","https://openalex.org/W2227373247","https://openalex.org/W2253033732","https://openalex.org/W2255330917","https://openalex.org/W2255570302","https://openalex.org/W2257660895","https://openalex.org/W2258295221","https://openalex.org/W2269247374","https://openalex.org/W2274948752","https://openalex.org/W2291447188","https://openalex.org/W2397548292","https://openalex.org/W2406512128","https://openalex.org/W2409169701","https://openalex.org/W2412521257","https://openalex.org/W2416366082","https://openalex.org/W2416957726","https://openalex.org/W2417993181","https://openalex.org/W2418088515","https://openalex.org/W2418855280","https://openalex.org/W2419170672","https://openalex.org/W2426305656","https://openalex.org/W2436271868","https://openalex.org/W2546825004","https://openalex.org/W4243932715"],"related_works":["https://openalex.org/W2071822872","https://openalex.org/W2030818307","https://openalex.org/W2083165690","https://openalex.org/W2439474859","https://openalex.org/W1947562604","https://openalex.org/W1970350500","https://openalex.org/W2323535782","https://openalex.org/W2328222934","https://openalex.org/W2414944519","https://openalex.org/W1996935284"],"abstract_inverted_index":{"5-Fluorouracil":[0],"(5-FU)":[1],"modulation":[2],"with":[3,21,32,140],"either":[4],"folinic":[5],"acid":[6],"(FA)":[7],"or":[8],"methotrexate":[9],"(MTX)":[10],"has":[11],"improved":[12],"5-FU's":[13,26],"potential":[14],"cytoreductivity.":[15,27],"We":[16],"combined":[17],"MTX":[18,40],"and":[19],"FA":[20,48,65],"5-FU":[22,58,128],"to":[23,45,119],"further":[24],"augment":[25],"Patients":[28,72],"(n":[29,82],"=":[30,83],"34)":[31],"advanced":[33],"colorectal":[34],"carcinoma":[35],"were":[36,66,73],"first":[37],"given":[38],"intravenous":[39],"(escalated":[41],"from":[42],"30":[43],"mg/m2":[44],"70":[46],"mg/m2).":[47,60],"(100":[49],"mg/m2)":[50],"was":[51,102],"infused":[52],"17-24":[53],"hr":[54,69],"later,":[55],"followed":[56],"by":[57,129],"(600":[59],"Oral":[61],"rescue":[62],"doses":[63],"of":[64,87,127],"begun":[67],"24":[68],"after":[70],"MTX.":[71],"treated":[74,80],"every":[75],"2":[76],"weeks.":[77],"No":[78],"previously":[79],"patient":[81],"6)":[84],"responded.":[85],"Eight":[86],"the":[88,125,136],"remaining":[89],"28":[90],"(29%)":[91],"(95%":[92],"confidence":[93],"interval,":[94],"15-47%)":[95],"patients":[96,113],"achieved":[97],"a":[98,120],"PR.":[99],"Median":[100],"survival":[101],"9.3":[103],"months.":[104],"Toxicity":[105],"(primarily":[106],"gastrointestinal)":[107],"necessitated":[108],"dosage":[109],"modification":[110],"in":[111,117],"10":[112],"(29%).":[114],"These":[115],"results,":[116],"addition":[118],"literature":[121],"review,":[122],"reveal":[123],"that":[124],"manipulation":[126],"two":[130],"modulating":[131],"agents":[132],"does":[133],"not":[134],"improve":[135],"response":[137],"rate":[138],"seen":[139],"single-agent":[141],"modulation.":[142]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}