{"id":"https://openalex.org/W1987363380","doi":"https://doi.org/10.1007/s11745-011-3638-x","title":"Myristic Acid Increases Dihydroceramide \u03944\u2010Desaturase 1 (DES1) Activity in Cultured Rat Hepatocytes","display_name":"Myristic Acid Increases Dihydroceramide \u03944\u2010Desaturase 1 (DES1) Activity in Cultured Rat Hepatocytes","publication_year":2011,"publication_date":"2011-12-03","ids":{"openalex":"https://openalex.org/W1987363380","doi":"https://doi.org/10.1007/s11745-011-3638-x","mag":"1987363380","pmid":"https://pubmed.ncbi.nlm.nih.gov/22139871"},"language":"en","primary_location":{"id":"doi:10.1007/s11745-011-3638-x","doi":"https://doi.org/10.1007/s11745-011-3638-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-011-3638-x","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035355633","display_name":"H\u00e9l\u00e8ne Ezanno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Ezanno","raw_affiliation_strings":["Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542511","display_name":"J\u00e9r\u00f4me Le Bloc\u2019h","orcid":"https://orcid.org/0009-0003-4123-5148","observed_orcids":["https://orcid.org/0009-0003-4123-5148"]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me le Bloc\u2019h","raw_affiliation_strings":["Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106184790","display_name":"Erwan Beauchamp","orcid":"https://orcid.org/0009-0007-9567-695X","observed_orcids":["https://orcid.org/0009-0007-9567-695X"]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Erwan Beauchamp","raw_affiliation_strings":["Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091873648","display_name":"Dominique Lagadic\u2010Gossmann","orcid":"https://orcid.org/0000-0002-4888-236X","observed_orcids":["https://orcid.org/0000-0002-4888-236X"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I4405258264","display_name":"Universit\u00e9 Rennes 1","ror":"https://ror.org/00crteh33","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258264","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Lagadic\u2010Gossmann","raw_affiliation_strings":["EA 4427 SeRAIC/IRSET, Universit\u00e9 Rennes 1 IFR 140 Rennes France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 4427 SeRAIC/IRSET, Universit\u00e9 Rennes 1 IFR 140 Rennes France","institution_ids":["https://openalex.org/I4210108239","https://openalex.org/I4405258264","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028675960","display_name":"Philippe Legrand","orcid":"https://orcid.org/0000-0001-5763-4854","observed_orcids":["https://orcid.org/0000-0001-5763-4854"]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Legrand","raw_affiliation_strings":["Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007997759","display_name":"Vincent Rioux","orcid":"https://orcid.org/0000-0001-9837-1675","observed_orcids":["https://orcid.org/0000-0001-9837-1675"]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Vincent Rioux","raw_affiliation_strings":["Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie\u2010Nutrition Humaine, Agrocampus Ouest INRA USC 2012 CS 84215, 65 rue de Saint\u2010Brieuc Rennes cedex 35042 France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007997759"],"corresponding_institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4387154544"],"apc_list":{"value":3589,"currency":"USD","value_usd":3589},"apc_paid":null,"fwci":0.428,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.56445983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"2","first_page":"117","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myristic-acid","display_name":"myristic acid","score":0.8659999966621399},{"id":"https://openalex.org/keywords/n-myristoylation","display_name":"N-myristoylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ceramide-biosynthesis","display_name":"ceramide biosynthesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mitochondrial-localization","display_name":"mitochondrial localization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9490000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7957943677902222},{"id":"https://openalex.org/C77207865","wikidata":"https://www.wikidata.org/wiki/Q25794","display_name":"Myristoylation","level":3,"score":0.7509676218032837},{"id":"https://openalex.org/C2778483698","wikidata":"https://www.wikidata.org/wiki/Q422658","display_name":"Myristic acid","level":4,"score":0.741549551486969},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.6111127734184265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5060815215110779},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47993308305740356},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.45480722188949585},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4136536419391632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3847290575504303},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2992091774940491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2695884704589844},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.172498881816864},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1520356833934784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13204801082611084},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019814","descriptor_name":"Myristic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11745-011-3638-x","doi":"https://doi.org/10.1007/s11745-011-3638-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-011-3638-x","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},{"id":"pmid:22139871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22139871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00808026v1","doi":null,"is_oa":false,"landing_page_url":"https://institut-agro-rennes-angers.hal.science/hal-00808026","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipids, 2011, 47 (2), pp.117-128. ⟨10.1007/s11745-011-3638-x⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1154045829","https://openalex.org/W1536767595","https://openalex.org/W1539732094","https://openalex.org/W1588502587","https://openalex.org/W1603276636","https://openalex.org/W1840395063","https://openalex.org/W1928593456","https://openalex.org/W1969906715","https://openalex.org/W1971062375","https://openalex.org/W1972241057","https://openalex.org/W1973504792","https://openalex.org/W1975164158","https://openalex.org/W1976791967","https://openalex.org/W1976829005","https://openalex.org/W1980050556","https://openalex.org/W1984142578","https://openalex.org/W1987888500","https://openalex.org/W2000099744","https://openalex.org/W2003545173","https://openalex.org/W2003853320","https://openalex.org/W2011925577","https://openalex.org/W2017729786","https://openalex.org/W2018022482","https://openalex.org/W2023800753","https://openalex.org/W2024817554","https://openalex.org/W2027023788","https://openalex.org/W2029072796","https://openalex.org/W2031938486","https://openalex.org/W2035402726","https://openalex.org/W2038078222","https://openalex.org/W2041827697","https://openalex.org/W2050892074","https://openalex.org/W2065766712","https://openalex.org/W2072031497","https://openalex.org/W2088044853","https://openalex.org/W2090063199","https://openalex.org/W2090784961","https://openalex.org/W2094103449","https://openalex.org/W2102253975","https://openalex.org/W2103244006","https://openalex.org/W2104901736","https://openalex.org/W2118338384","https://openalex.org/W2121636949","https://openalex.org/W2132207276","https://openalex.org/W2143256430","https://openalex.org/W2147339290","https://openalex.org/W2151529440","https://openalex.org/W2156596868","https://openalex.org/W2161927466","https://openalex.org/W2168821261","https://openalex.org/W2573791399"],"related_works":["https://openalex.org/W1973504792","https://openalex.org/W2089372892","https://openalex.org/W6921963611","https://openalex.org/W2147339290","https://openalex.org/W2132207276","https://openalex.org/W2090063199","https://openalex.org/W2779936434","https://openalex.org/W2050892074","https://openalex.org/W2018921058","https://openalex.org/W2060849989"],"abstract_inverted_index":{"Dihydroceramide":[0],"\u03944-desaturase":[1],"1":[2],"(DES1)":[3],"catalyzes":[4],"the":[5,9,17,25,29,47,50,60,65,69,97,100,107,127,139,151,155,158,174,179,182,196,236,245],"last":[6],"step":[7],"of":[8,16,19,28,49,59,94,99,144,181,247],"de":[10],"novo":[11],"ceramide":[12,78],"biosynthesis,":[13],"which":[14,177],"consists":[15],"introduction":[18],"a":[20,86],"trans":[21],"\u03944-double":[22],"bond":[23],"in":[24,53,64,77,85,117,133,149,173,204,216,240],"carbon":[26],"chain":[27],"dihydroceramide.":[30],"It":[31],"was":[32,103,111,126,147,169,195,219],"previously":[33],"observed":[34],"that":[35,124,187],"myristic":[36,193,213,237],"acid":[37,194],"binds":[38],"DES1":[39,52,109,125,146,202,217,241],"through":[40],"N-myristoylation.":[41],"This":[42],"N-terminal":[43,233],"modification":[44],"significantly":[45],"increased":[46],"activity":[48,218,242],"recombinant":[51,87,142,161],"COS-7":[54,88],"cells":[55],"and":[56,154,209],"targeted":[57],"part":[58],"enzyme":[61,110],"initially":[62],"present":[63,101],"endoplasmic":[66,152,175],"reticulum":[67,153],"to":[68,74,104,189,199,222,231],"mitochondrial":[70,210],"outer":[71],"membrane,":[72],"leading":[73],"an":[75,167],"increase":[76,200,215,239],"levels.":[79],"Since":[80],"these":[81],"results":[82],"were":[83],"obtained":[84],"cell":[89,207],"model":[90],"with":[91],"high":[92],"expression":[93,227],"rat":[95,119,134,145],"DES1,":[96],"purpose":[98],"study":[102],"investigate":[105],"if":[106],"native":[108,201],"really":[112],"upregulated":[113],"by":[114,166],"its":[115,232],"N-myristoylation":[116],"cultured":[118],"hepatocytes.":[120,135],"We":[121],"first":[122],"showed":[123,186],"main":[128],"dihydroceramide":[129],"desaturase":[130],"isoform":[131],"expressed":[132],"In":[136],"this":[137],"model,":[138],"wild-type":[140],"myristoylable":[141],"form":[143,162],"found":[148],"both":[150,205],"mitochondria":[156],"whereas":[157],"mutated":[159],"non-myristoylable":[160],"(N-terminal":[163],"glycine":[164],"replaced":[165],"alanine)":[168],"almost":[170],"exclusively":[171],"localized":[172],"reticulum,":[176],"evidenced":[178],"importance":[180],"myristoylation.":[183,234],"Then,":[184],"we":[185],"compared":[188],"other":[190],"fatty":[191],"acids,":[192],"only":[197],"one":[198],"activity,":[203],"total":[206],"lysates":[208],"fractions.":[211],"The":[212],"acid-associated":[214,238],"not":[220],"linked":[221],"elevated":[223],"mRNA":[224],"or":[225],"protein":[226],"but":[228],"more":[229],"likely":[230],"Finally,":[235],"slightly":[243],"enhanced":[244],"number":[246],"apoptotic":[248],"cells.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}