{"id":"https://openalex.org/W1987312342","doi":"https://doi.org/10.1021/ac702566e","title":"Surface Plasmon Resonance Study of Protein\u2212Carbohydrate Interactions Using Biotinylated Sialosides","display_name":"Surface Plasmon Resonance Study of Protein\u2212Carbohydrate Interactions Using Biotinylated Sialosides","publication_year":2008,"publication_date":"2008-05-08","ids":{"openalex":"https://openalex.org/W1987312342","doi":"https://doi.org/10.1021/ac702566e","mag":"1987312342","pmid":"https://pubmed.ncbi.nlm.nih.gov/18461973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2586005"},"language":"en","primary_location":{"id":"doi:10.1021/ac702566e","doi":"https://doi.org/10.1021/ac702566e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac702566e","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC2586005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008821444","display_name":"Matthew J. Linman","orcid":"https://orcid.org/0000-0003-4243-2568","observed_orcids":["https://orcid.org/0000-0003-4243-2568"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Linman","raw_affiliation_strings":["Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072450002","display_name":"Joseph D. Taylor","orcid":"https://orcid.org/0000-0002-9882-9727","observed_orcids":["https://orcid.org/0000-0002-9882-9727"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Taylor","raw_affiliation_strings":["Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018882725","display_name":"Hai Yu","orcid":"https://orcid.org/0000-0002-4378-0532","observed_orcids":["https://orcid.org/0000-0002-4378-0532"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Yu","raw_affiliation_strings":["Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329932","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0002-3160-614X","observed_orcids":["https://orcid.org/0000-0002-3160-614X"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015457582","display_name":"Quan Jason Cheng","orcid":"https://orcid.org/0000-0003-0934-358X","observed_orcids":["https://orcid.org/0000-0003-0934-358X"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Quan Cheng","raw_affiliation_strings":["Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Riverside, California 92521, and Department of Chemistry, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015457582"],"corresponding_institution_ids":["https://openalex.org/I103635307","https://openalex.org/I84218800"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.2052,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.96617355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"80","issue":"11","first_page":"4007","last_page":"4013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-carbohydrate-interactions","display_name":"carbohydrate-protein interactions","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lectin-carbohydrate-binding","display_name":"lectin-carbohydrate binding","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sambucus-nigra-agglutinin","display_name":"Sambucus nigra agglutinin","score":0.890999972820282},{"id":"https://openalex.org/keywords/maackia-amurensis-lectin","display_name":"Maackia amurensis lectin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wheat-germ-agglutinin","display_name":"wheat germ agglutinin","score":1.0},{"id":"https://openalex.org/keywords/surface-regeneration","display_name":"surface regeneration","score":0.5109999775886536},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5149999856948853},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9519721269607544},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.7411677241325378},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.6567919850349426},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.6008175015449524},{"id":"https://openalex.org/C2780175098","wikidata":"https://www.wikidata.org/wiki/Q2647799","display_name":"Wheat germ agglutinin","level":3,"score":0.5482578277587891},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.5371824502944946},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.5138795375823975},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.5044666528701782},{"id":"https://openalex.org/C32786932","wikidata":"https://www.wikidata.org/wiki/Q4914013","display_name":"Binding constant","level":3,"score":0.44796210527420044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3463335633277893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3187029957771301},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3175409734249115},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.11323139071464539},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.08948695659637451},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001360","descriptor_name":"Avidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005026","descriptor_name":"Ethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D037121","descriptor_name":"Plant Lectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054788","descriptor_name":"Ribosome Inactivating Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/ac702566e","doi":"https://doi.org/10.1021/ac702566e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac702566e","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:18461973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18461973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1453999","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2586005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2586005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2586005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1453999","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2586005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G11063979","display_name":"Studies of naturally occurring structurally modified carbohydrates","funder_award_id":"R01GM076360","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W89065758","https://openalex.org/W594852482","https://openalex.org/W596881595","https://openalex.org/W1508075941","https://openalex.org/W1547846772","https://openalex.org/W1567197932","https://openalex.org/W1579065718","https://openalex.org/W1964353947","https://openalex.org/W1966722132","https://openalex.org/W1967063788","https://openalex.org/W1968678481","https://openalex.org/W1968794704","https://openalex.org/W1972135297","https://openalex.org/W1972566197","https://openalex.org/W1976663363","https://openalex.org/W1976859231","https://openalex.org/W1982600657","https://openalex.org/W1987464059","https://openalex.org/W1989730031","https://openalex.org/W1990783969","https://openalex.org/W1991735525","https://openalex.org/W2007634300","https://openalex.org/W2017218164","https://openalex.org/W2018692487","https://openalex.org/W2018885419","https://openalex.org/W2019418566","https://openalex.org/W2020962003","https://openalex.org/W2023269042","https://openalex.org/W2024017427","https://openalex.org/W2035647257","https://openalex.org/W2038996493","https://openalex.org/W2045589130","https://openalex.org/W2055800251","https://openalex.org/W2064426577","https://openalex.org/W2064551567","https://openalex.org/W2067012210","https://openalex.org/W2074612147","https://openalex.org/W2076697448","https://openalex.org/W2087684818","https://openalex.org/W2089189397","https://openalex.org/W2092602198","https://openalex.org/W2093495124","https://openalex.org/W2102349489","https://openalex.org/W2129828179","https://openalex.org/W2133796904","https://openalex.org/W2138072908","https://openalex.org/W2154115123","https://openalex.org/W2161910429","https://openalex.org/W2165262749","https://openalex.org/W2312756716","https://openalex.org/W2949069337","https://openalex.org/W4211014836","https://openalex.org/W4211079765","https://openalex.org/W4239828048","https://openalex.org/W4251775387","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2044546766","https://openalex.org/W2460472740","https://openalex.org/W2129828179","https://openalex.org/W2415973770","https://openalex.org/W1599663837","https://openalex.org/W2411620058","https://openalex.org/W1982572429","https://openalex.org/W1918882121","https://openalex.org/W7223429206","https://openalex.org/W4323966236"],"abstract_inverted_index":{"Lectins":[0],"are":[1],"carbohydrate":[2,73,270],"binding":[3,87,95,128,164,179,287,298],"proteins":[4],"found":[5],"in":[6,75,134,186,313],"plants,":[7],"animals,":[8],"and":[9,57,71,83,91,103,115,137,205,277,296],"microorganisms.":[10],"They":[11],"serve":[12],"as":[13],"important":[14],"models":[15],"for":[16,162,268,309],"understanding":[17],"protein-carbohydrate":[18],"interactions":[19,40,56,200,312],"at":[20],"the":[21,27,52,58,69,72,143,172,177,187,227,237,248,252,255,269,281],"molecular":[22],"level.":[23],"We":[24],"report":[25],"here":[26],"fabrication":[28],"of":[29,34,49,60,86,93,157,193,195,265,274,283,300],"a":[30,76,146,241,262],"novel":[31],"sensing":[32],"interface":[33],"biotinylated":[35],"sialosides":[36,125],"to":[37,51,130,165,280,294],"probe":[38],"lectin-carbohydrate":[39],"using":[41,54,98,240],"surface":[42,53,223,249,259],"plasmon":[43],"resonance":[44],"spectroscopy":[45],"(SPR).":[46],"The":[47,89,120,210],"attachment":[48],"carbohydrates":[50],"biotin-NeutrAvidin":[55,256],"implementation":[59],"an":[61,152],"inert":[62],"hydrophilic":[63],"hexaethylene":[64],"glycol":[65],"spacer":[66],"(HEG)":[67],"between":[68],"biotin":[70],"result":[74],"well-defined":[77],"interface,":[78],"enabling":[79],"desired":[80],"orientational":[81],"flexibility":[82],"enhanced":[84],"access":[85],"partners.":[88],"specificity":[90],"sensitivity":[92],"lectin":[94,109],"were":[96,207],"characterized":[97],"Sambucus":[99],"nigra":[100],"agglutinin":[101,118],"(SNA)":[102],"other":[104],"lectins":[105],"including":[106],"Maackia":[107],"amurensis":[108],"(MAL),":[110],"concanavalin":[111],"A":[112,181],"(Con":[113],"A),":[114],"wheat":[116],"germ":[117],"(WGA).":[119],"results":[121],"indicate":[122],"that":[123,218],"alpha2,6-linked":[124],"exhibit":[126],"high":[127,263],"affinity":[129,144,267],"SNA,":[131],"while":[132],"alteration":[133],"sialyl":[135,275],"linkage":[136],"terminal":[138],"sialic":[139],"acid":[140],"structure":[141],"compromises":[142],"by":[145],"varied":[147],"degree.":[148],"Quantitative":[149],"analysis":[150],"yields":[151],"equilibrium":[153,178],"dissociation":[154],"constant":[155],"(KD)":[156],"777":[158],"+/-":[159],"93":[160],"nM":[161],"SNA":[163],"Neu5Ac":[166],"alpha2,6-LHEB.":[167],"Transient":[168],"SPR":[169],"kinetics":[170],"confirms":[171],"K":[173],"D":[174],"value":[175],"from":[176],"studies.":[180],"linear":[182],"relationship":[183],"was":[184],"obtained":[185],"10-100":[188],"microg/mL":[189],"range":[190,229],"with":[191,201,213],"limit":[192],"detection":[194],"approximately":[196],"50":[197],"nM.":[198],"Weak":[199],"MAL,":[202],"Con":[203],"A,":[204],"WGA":[206],"also":[208],"quantified.":[209],"control":[211],"experiment":[212],"bovine":[214],"serum":[215],"albumin":[216],"indicates":[217],"nonspecific":[219],"interaction":[220],"on":[221,236,286],"this":[222],"is":[224],"insignificant":[225],"over":[226],"concentration":[228],"studied.":[230],"Multiple":[231],"experiments":[232],"can":[233],"be":[234,291],"performed":[235],"same":[238],"substrate":[239],"glycine":[242],"stripping":[243],"buffer,":[244],"which":[245],"selectively":[246],"regenerates":[247],"without":[250],"damaging":[251],"sialoside":[253],"or":[254],"interface.":[257],"This":[258],"design":[260],"retains":[261],"degree":[264],"native":[266],"motifs,":[271],"allowing":[272],"distinction":[273],"linkages":[276],"investigation":[278],"pertaining":[279],"effect":[282],"functional":[284],"group":[285],"efficiency.":[288],"It":[289],"could":[290],"easily":[292],"modified":[293],"identify":[295],"quantify":[297],"patterns":[299],"any":[301],"low-affinity":[302],"biologically":[303],"relevant":[304],"systems,":[305],"opening":[306],"new":[307],"avenues":[308],"probing":[310],"carbohydrate-protein":[311],"real":[314],"time.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}