{"id":"https://openalex.org/W1987299592","doi":"https://doi.org/10.1073/pnas.73.11.3857","title":"Subcellular localization of S-adenosyl-L-methionine:tRNA methyltransferases with aminoacyl-tRNA synthetases in human and mouse: normal and leukemic leukocytes.","display_name":"Subcellular localization of S-adenosyl-L-methionine:tRNA methyltransferases with aminoacyl-tRNA synthetases in human and mouse: normal and leukemic leukocytes.","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W1987299592","doi":"https://doi.org/10.1073/pnas.73.11.3857","mag":"1987299592","pmid":"https://pubmed.ncbi.nlm.nih.gov/11466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/431241"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.73.11.3857","doi":"https://doi.org/10.1073/pnas.73.11.3857","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.73.11.3857","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC431241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035408700","display_name":"Paul F. Agris","orcid":"https://orcid.org/0000-0003-3848-2458","observed_orcids":["https://orcid.org/0000-0003-3848-2458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P F Agris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025360025","display_name":"D K Woolverton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Woolverton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036844367","display_name":"David R. Setzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Setzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7473,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64253293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"73","issue":"11","first_page":"3857","last_page":"3861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/leukemic-leukocytes","display_name":"leukemic leukocytes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/microsomal-fraction","display_name":"microsomal fraction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/trna-modification","display_name":"tRNA modification","score":0.7179999947547913},{"id":"https://openalex.org/keywords/trna-aminoacylation","display_name":"tRNA aminoacylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/enzyme-complex","display_name":"enzyme complex","score":0.6779999732971191},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.8089379072189331},{"id":"https://openalex.org/C151238385","wikidata":"https://www.wikidata.org/wiki/Q4746444","display_name":"Aminoacylation","level":5,"score":0.775603175163269},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7381571531295776},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.699481189250946},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6446003317832947},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6428138017654419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6175180077552795},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6165645718574524},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6055999994277954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.525917649269104},{"id":"https://openalex.org/C132946820","wikidata":"https://www.wikidata.org/wiki/Q2509459","display_name":"Differential centrifugation","level":2,"score":0.42817431688308716},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41951489448547363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.344510018825531},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3020765483379364},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.22424370050430298},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.19916373491287231},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08566862344741821}],"mesh":[{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002414","descriptor_name":"Cations, Monovalent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.73.11.3857","doi":"https://doi.org/10.1073/pnas.73.11.3857","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.73.11.3857","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:65811","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC431241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:431241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/431241","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:11466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:65811","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC431241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1577406368","https://openalex.org/W1775749144","https://openalex.org/W1873200295","https://openalex.org/W1964083748","https://openalex.org/W1973585922","https://openalex.org/W1979704489","https://openalex.org/W1979816621","https://openalex.org/W1993699070","https://openalex.org/W1994704723","https://openalex.org/W2000796689","https://openalex.org/W2046006000","https://openalex.org/W2049904856","https://openalex.org/W2052678223","https://openalex.org/W2053387982","https://openalex.org/W2055709289","https://openalex.org/W2068914859","https://openalex.org/W2076142302","https://openalex.org/W2087721796","https://openalex.org/W2092734623","https://openalex.org/W2467788816"],"related_works":["https://openalex.org/W2112352727","https://openalex.org/W2000796689","https://openalex.org/W1986412386","https://openalex.org/W1982041077","https://openalex.org/W2076085870","https://openalex.org/W2087850900","https://openalex.org/W1965337847","https://openalex.org/W7132188989","https://openalex.org/W2093711344","https://openalex.org/W2395507942"],"abstract_inverted_index":{"The":[0,56,102,155],"subcellular":[1,33],"distributions":[2],"of":[3,14,26,60,86,116,125,134,157,166,172,184],"S-adenosyl-L-methionine:tRNA":[4],"methyltransferases":[5,159],"and":[6,16,19,36,39,41,53,63,99,160],"aminoacyl-tRNA":[7,135],"synthetases":[8,136,161],"were":[9,66,91,137,149],"investigated":[10],"with":[11],"the":[12,70,73,82,97,117,121,163,167,170,177,182],"use":[13],"human":[15],"mouse":[17],"normal":[18,126,151],"leukemic":[20,106,153],"leukocyte":[21],"cell":[22,28,78],"lines.":[23],"Differential":[24],"centrifugation":[25],"homogenized":[27],"suspensions":[29],"produced":[30],"three":[31],"pelleted":[32],"fractions":[34,124],"(nuclear":[35],"membrane,":[37],"microsomal,":[38],"postribosomal)":[40],"a":[42,109],"supernatant":[43],"fraction.":[44],"Each":[45],"fraction":[46,104,165],"was":[47],"assayed":[48],"for":[49,143,176],"both":[50],"methyltransferase":[51,62,110],"activity":[52,112,156],"synthetase":[54,64],"activity.":[55],"largest":[57],"amounts,":[58],"40-50%,":[59],"total":[61],"activities":[65,85,133],"localized":[67],"in":[68,96],"either":[69],"microsomal":[71,98,118],"or":[72,152],"postribosomal":[74,100,164],"fractions,":[75,146],"depending":[76],"on":[77],"type.":[79],"In":[80],"addition,":[81],"highest":[83],"specific":[84,111],"these":[87,144],"two":[88,123,145],"enzyme":[89,174],"systems":[90],"found":[92,138],"to":[93,139],"be":[94,140],"present":[95],"fractions.":[101],"psotribosomal":[103],"from":[105,150],"leukocytes":[107,127],"had":[108,128],"higher":[113],"than":[114],"that":[115],"fraction,":[119],"while":[120],"same":[122],"approximately":[129,141],"equal":[130,142],"activities.":[131],"Specific":[132],"whether":[147],"they":[148],"leukocytes.":[154],"tRNA":[158],"within":[162],"cytoplasm":[168],"suggests":[169],"existence":[171],"high-molecular-weight":[173],"complexes":[175],"modification":[178],"as":[179,181],"well":[180],"aminoacylation":[183],"tRNA.":[185]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}