{"id":"https://openalex.org/W1987222012","doi":"https://doi.org/10.1002/cncr.10918","title":"Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors","display_name":"Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors","publication_year":2002,"publication_date":"2002-10-25","ids":{"openalex":"https://openalex.org/W1987222012","doi":"https://doi.org/10.1002/cncr.10918","mag":"1987222012","pmid":"https://pubmed.ncbi.nlm.nih.gov/12404281"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.10918","doi":"https://doi.org/10.1002/cncr.10918","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10918","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10918","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10918","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113821547","display_name":"Tsuneharu Miki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsuneharu Miki","raw_affiliation_strings":["Department of Urology, Kyoto Prefectural University of Medicine, Japan. tmiki@koto.kpu-m.ac.jp","Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kyoto Prefectural University of Medicine, Japan. tmiki@koto.kpu-m.ac.jp","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080691001","display_name":"Yoichi Mizutani","orcid":"https://orcid.org/0000-0002-5890-8172","observed_orcids":["https://orcid.org/0000-0002-5890-8172"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Mizutani","raw_affiliation_strings":["Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088384086","display_name":"Norio Nonomura","orcid":"https://orcid.org/0000-0002-6522-6233","observed_orcids":["https://orcid.org/0000-0002-6522-6233"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Nonomura","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103678940","display_name":"Takeshi Nomoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Nomoto","raw_affiliation_strings":["Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089793884","display_name":"Masahiro Nakao","orcid":"https://orcid.org/0000-0001-7848-1172","observed_orcids":["https://orcid.org/0000-0001-7848-1172"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Nakao","raw_affiliation_strings":["Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Dept. of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103907751","display_name":"Shigeru Saiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Saiki","raw_affiliation_strings":["Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110964334","display_name":"Toshihiko Kotake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Kotake","raw_affiliation_strings":["Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109973679","display_name":"\u00c4k\u00efh\u00efko Okuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Okuyama","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113821547"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":5.1482,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95036291,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"95","issue":"9","first_page":"1879","last_page":"1885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/nedaplatin","display_name":"nedaplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/salvage-chemotherapy","display_name":"salvage chemotherapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/refractory-germ-cell-tumors","display_name":"refractory germ cell tumors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/camptothecin-derivatives","display_name":"camptothecin derivatives","score":0.8389999866485596},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9100000262260437},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.9222862720489502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.89329594373703},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7686290740966797},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.6919596195220947},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6801856756210327},{"id":"https://openalex.org/C2778203143","wikidata":"https://www.wikidata.org/wiki/Q6986146","display_name":"Nedaplatin","level":4,"score":0.6631704568862915},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.6179693341255188},{"id":"https://openalex.org/C2776938808","wikidata":"https://www.wikidata.org/wiki/Q1737977","display_name":"Germ cell tumors","level":3,"score":0.5953142642974854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5553304553031921},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.543736457824707},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5363019704818726},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4258134365081787},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4181158244609833},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36635836958885193},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29260361194610596},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.053878337144851685},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.10918","doi":"https://doi.org/10.1002/cncr.10918","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10918","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10918","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:12404281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12404281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cncr.10918","doi":"https://doi.org/10.1002/cncr.10918","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10918","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10918","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G535555441","display_name":"Study on gene analysis and gene expresssion associated with differentiation in testicular germ cell tumor","funder_award_id":"11470341","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6358576478","display_name":"Analysis of tumor suppressor gene in refractory or relapsed germ cell tumors and its therapeutic application","funder_award_id":"14370519","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987222012.pdf","grobid_xml":"https://content.openalex.org/works/W1987222012.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W75846784","https://openalex.org/W1748674096","https://openalex.org/W1819940966","https://openalex.org/W1854574445","https://openalex.org/W1868039889","https://openalex.org/W1879666912","https://openalex.org/W1933983909","https://openalex.org/W1965352960","https://openalex.org/W1971928740","https://openalex.org/W1979086997","https://openalex.org/W2015129821","https://openalex.org/W2036972586","https://openalex.org/W2057331147","https://openalex.org/W2058078699","https://openalex.org/W2060932390","https://openalex.org/W2067299834","https://openalex.org/W2081406767","https://openalex.org/W2090909898","https://openalex.org/W2095402226","https://openalex.org/W2105235272","https://openalex.org/W2124999940","https://openalex.org/W2134854919","https://openalex.org/W2157562330","https://openalex.org/W2174727426","https://openalex.org/W2229089518","https://openalex.org/W2234996698","https://openalex.org/W2239815859","https://openalex.org/W2314927739","https://openalex.org/W2323139555","https://openalex.org/W2325651197"],"related_works":["https://openalex.org/W2587308436","https://openalex.org/W843930759","https://openalex.org/W2334531170","https://openalex.org/W7097421121","https://openalex.org/W2590342414","https://openalex.org/W2156540973","https://openalex.org/W3012344816","https://openalex.org/W7096589434","https://openalex.org/W2312237978","https://openalex.org/W2095688211"],"abstract_inverted_index":{"BACKGROUND:":[0],"Only":[1],"20-30%":[2],"of":[3,22,32,42,57,66,115,122,136,167,174,240,243],"patients":[4,131,158,165,214,247],"with":[5,45,49,83,101,201,205,215,248],"refractory":[6,102,216,249],"or":[7,52,75,90,207],"recurrent":[8],"germ":[9],"cell":[10],"tumors":[11],"(GCT)":[12],"are":[13],"cured":[14],"by":[15],"salvage":[16,43,244],"chemotherapy.":[17,118],"Irinotecan,":[18],"a":[19,25,30,55,175,227],"new":[20],"derivative":[21,56],"camptothecin,":[23],"is":[24,124],"potent":[26],"anticancer":[27,211],"agent":[28],"against":[29],"variety":[31],"solid":[33],"cancers.":[34],"The":[35,62,119,144,178],"current":[36],"pilot":[37,195],"study":[38,196,224],"investigated":[39],"the":[40,116,168,187,199,234,241],"efficacy":[41],"chemotherapy":[44,64,200,236,245],"irinotecan":[46,69,202],"in":[47,81,105,203],"combination":[48,63,82,117,204,235],"cisplatin":[50],"(CDDP)":[51],"nedaplatin":[53],"(NDP),":[54],"cisplatin,":[58],"for":[59,140,213,246],"GCT.":[60,250],"METHODS:":[61],"consisted":[65],"100-150":[67],"mg/m(2)":[68,77,85,92],"on":[70,78,87,94],"Days":[71,88],"1":[72,80,96],"and":[73,142,153,170],"15":[74],"200-300":[76],"Day":[79,95],"20":[84],"CDDP":[86,206],"1-5":[89],"100":[91],"NDP":[93,208],"every":[97],"4":[98],"weeks.":[99],"Patients":[100],"GCT,":[103,217],"ranging":[104],"age":[106],"from":[107],"17":[108],"to":[109],"43":[110],"years,":[111],"received":[112],"2-11":[113],"cycles":[114],"median":[120],"duration":[121],"follow-up":[123],"28":[125],"months":[126],"(8-140":[127],"months).":[128],"RESULTS:":[129],"Twenty":[130],"entered":[132],"this":[133,223],"study,":[134],"18":[135],"whom":[137],"were":[138],"assessed":[139],"response":[141,145],"toxicity.":[143],"rate":[146,181],"was":[147,182,186,191],"50":[148],"%":[149],"(two":[150],"complete":[151],"responses":[152],"seven":[154],"partial":[155],"responses).":[156],"Nine":[157],"remain":[159],"alive":[160],"without":[161,218],"disease.":[162],"However,":[163],"six":[164],"died":[166,173],"disease":[169],"one":[171,239],"patient":[172],"brain":[176],"glioma.":[177],"5-year":[179],"survival":[180],"approximately":[183],"53%.":[184],"Myelosuppression":[185],"major":[188],"toxicity,":[189],"but":[190],"manageable.":[192],"CONCLUSIONS:":[193],"This":[194],"demonstrates":[197],"that":[198,233],"showed":[209],"significant":[210],"activity":[212],"serious":[219],"side":[220],"effects.":[221],"Although":[222],"comprised":[225],"only":[226],"few":[228],"patients,":[229],"these":[230],"findings":[231],"suggest":[232],"may":[237],"be":[238],"options":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
