{"id":"https://openalex.org/W1987168542","doi":"https://doi.org/10.1155/2014/614074","title":"Adipose Tissue and Adrenal Glands: Novel Pathophysiological Mechanisms and Clinical Applications","display_name":"Adipose Tissue and Adrenal Glands: Novel Pathophysiological Mechanisms and Clinical Applications","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1987168542","doi":"https://doi.org/10.1155/2014/614074","mag":"1987168542","pmid":"https://pubmed.ncbi.nlm.nih.gov/25018768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075085"},"language":"en","primary_location":{"id":"doi:10.1155/2014/614074","doi":"https://doi.org/10.1155/2014/614074","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/614074","pdf_url":"https://downloads.hindawi.com/journals/ije/2014/614074.pdf","source":{"id":"https://openalex.org/S123631873","display_name":"International Journal of Endocrinology","issn_l":"1687-8337","issn":["1687-8337","1687-8345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ije/2014/614074.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083560410","display_name":"Atil Y. Kargi","orcid":"https://orcid.org/0000-0003-1907-6569","observed_orcids":["https://orcid.org/0000-0003-1907-6569"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Atil Y. Kargi","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007644539","display_name":"Gianluca Iacobellis","orcid":"https://orcid.org/0000-0001-7888-9530","observed_orcids":["https://orcid.org/0000-0001-7888-9530"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianluca Iacobellis","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083560410"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":0.7351,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.55437195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2014","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7860000133514404},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.9330000281333923},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6000000238418579},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glucocorticoid-metabolism","display_name":"glucocorticoid metabolism","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7170000076293945},{"id":"https://openalex.org/keywords/adrenal-diseases","display_name":"adrenal disorders","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8205926418304443},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.747198760509491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7250564098358154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6737145185470581},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.6313197612762451},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.5985981822013855},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5928560495376587},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5299813747406006},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4456251859664917},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.4294249415397644},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.3749080300331116},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3649161458015442}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1155/2014/614074","doi":"https://doi.org/10.1155/2014/614074","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/614074","pdf_url":"https://downloads.hindawi.com/journals/ije/2014/614074.pdf","source":{"id":"https://openalex.org/S123631873","display_name":"International Journal of Endocrinology","issn_l":"1687-8337","issn":["1687-8337","1687-8345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3065047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075085","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4075085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Endocrinol","raw_type":"Text"},{"id":"pmid:25018768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25018768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.6325","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.6325","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/9a/IJE2014-614074.PMC4075085.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5b4905507ee248ccade652b375c537ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5b4905507ee248ccade652b375c537ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Endocrinology, Vol 2014 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2014/614074","doi":"https://doi.org/10.1155/2014/614074","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/614074","pdf_url":"https://downloads.hindawi.com/journals/ije/2014/614074.pdf","source":{"id":"https://openalex.org/S123631873","display_name":"International Journal of Endocrinology","issn_l":"1687-8337","issn":["1687-8337","1687-8345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987168542.pdf","grobid_xml":"https://content.openalex.org/works/W1987168542.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1489635597","https://openalex.org/W1535399883","https://openalex.org/W1604542334","https://openalex.org/W1661807651","https://openalex.org/W1904058160","https://openalex.org/W1973812648","https://openalex.org/W1973826125","https://openalex.org/W1976973182","https://openalex.org/W1980304913","https://openalex.org/W1989505891","https://openalex.org/W1991150745","https://openalex.org/W1992909944","https://openalex.org/W1995324236","https://openalex.org/W1996713062","https://openalex.org/W1996989437","https://openalex.org/W1998299672","https://openalex.org/W1999174748","https://openalex.org/W1999429145","https://openalex.org/W2001173097","https://openalex.org/W2002694466","https://openalex.org/W2011564895","https://openalex.org/W2012387040","https://openalex.org/W2013817923","https://openalex.org/W2013861279","https://openalex.org/W2017707617","https://openalex.org/W2020602591","https://openalex.org/W2022227132","https://openalex.org/W2025196819","https://openalex.org/W2028837850","https://openalex.org/W2037463613","https://openalex.org/W2039784350","https://openalex.org/W2047833988","https://openalex.org/W2050930379","https://openalex.org/W2051051060","https://openalex.org/W2056348170","https://openalex.org/W2057366329","https://openalex.org/W2058350561","https://openalex.org/W2061510535","https://openalex.org/W2062126483","https://openalex.org/W2065310133","https://openalex.org/W2065783198","https://openalex.org/W2075187033","https://openalex.org/W2080217697","https://openalex.org/W2080532540","https://openalex.org/W2081642136","https://openalex.org/W2083490874","https://openalex.org/W2085252992","https://openalex.org/W2089319338","https://openalex.org/W2090555756","https://openalex.org/W2091781256","https://openalex.org/W2095427240","https://openalex.org/W2098627686","https://openalex.org/W2100669908","https://openalex.org/W2102445277","https://openalex.org/W2104253488","https://openalex.org/W2104380511","https://openalex.org/W2106066419","https://openalex.org/W2106680203","https://openalex.org/W2109181100","https://openalex.org/W2111017518","https://openalex.org/W2112727925","https://openalex.org/W2114899481","https://openalex.org/W2116546975","https://openalex.org/W2117342292","https://openalex.org/W2123525661","https://openalex.org/W2127764698","https://openalex.org/W2129546749","https://openalex.org/W2131703525","https://openalex.org/W2131857378","https://openalex.org/W2133481218","https://openalex.org/W2133963705","https://openalex.org/W2142654873","https://openalex.org/W2148114970","https://openalex.org/W2149362701","https://openalex.org/W2152094259","https://openalex.org/W2156597872","https://openalex.org/W2158179602","https://openalex.org/W2161187682","https://openalex.org/W2163770481","https://openalex.org/W2164923353","https://openalex.org/W2171835251","https://openalex.org/W2281454947","https://openalex.org/W2323458614","https://openalex.org/W2328926651","https://openalex.org/W2602374010"],"related_works":["https://openalex.org/W7095749215","https://openalex.org/W2085252992","https://openalex.org/W4417200961","https://openalex.org/W1965340330","https://openalex.org/W2039503704","https://openalex.org/W2005692880","https://openalex.org/W2099796585","https://openalex.org/W7117256766","https://openalex.org/W2037933025","https://openalex.org/W2969373050"],"abstract_inverted_index":{"Hormones":[0],"produced":[1],"by":[2],"the":[3,39,76,99,113,117,123,131,152],"adrenal":[4,28,33,68,100,105,124],"glands":[5,101],"and":[6,15,55,80,102,126,133,141,148],"adipose":[7,51,90,127],"tissues":[8],"have":[9,95],"important":[10],"roles":[11,134],"in":[12,18,27,32,44,50,67,72,139],"normal":[13],"physiology":[14],"are":[16,71],"altered":[17],"many":[19],"disease":[20,142],"states.":[21],"Obesity":[22],"is":[23,62],"associated":[24],"with":[25,48,104],"changes":[26,49,66],"function,":[29],"including":[30,144],"increase":[31],"medullary":[34],"catecholamine":[35],"output,":[36],"alterations":[37],"of":[38,78,119,135,151],"hypothalamic-pituitary-adrenal":[40],"(HPA)":[41],"axis,":[42],"elevations":[43],"circulating":[45],"aldosterone":[46],"together":[47],"tissue":[52,91],"glucocorticoid":[53],"metabolism,":[54],"enhanced":[56],"adipocyte":[57],"mineralocorticoid":[58],"receptor":[59],"activity.":[60],"It":[61],"unknown":[63],"whether":[64],"these":[65],"endocrine":[69],"function":[70],"part":[73],"responsible":[74],"for":[75],"pathogenesis":[77],"obesity":[79],"related":[81],"comorbidities":[82],"or":[83,93],"represent":[84],"an":[85],"adaptive":[86],"response.":[87],"In":[88],"turn,":[89],"hormones":[92,106,138],"\"adipokines\"":[94],"direct":[96],"effects":[97],"on":[98,130],"interact":[103],"at":[107],"several":[108],"levels.":[109],"Here":[110],"we":[111],"review":[112],"emerging":[114],"evidence":[115],"supporting":[116],"existence":[118],"\"cross":[120],"talk\"":[121],"between":[122],"gland":[125],"tissue,":[128],"focusing":[129],"relevance":[132],"their":[136],"respective":[137],"health":[140],"states":[143],"obesity,":[145],"metabolic":[146],"syndrome,":[147],"primary":[149],"disorders":[150],"adrenals.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}