{"id":"https://openalex.org/W1987155995","doi":"https://doi.org/10.1038/pr.2014.86","title":"Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis","display_name":"Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis","publication_year":2014,"publication_date":"2014-06-18","ids":{"openalex":"https://openalex.org/W1987155995","doi":"https://doi.org/10.1038/pr.2014.86","mag":"1987155995","pmid":"https://pubmed.ncbi.nlm.nih.gov/24941216"},"language":"en","primary_location":{"id":"doi:10.1038/pr.2014.86","doi":"https://doi.org/10.1038/pr.2014.86","is_oa":false,"landing_page_url":"https://doi.org/10.1038/pr.2014.86","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073408436","display_name":"Weimin Gao","orcid":"https://orcid.org/0000-0001-6407-3258","observed_orcids":["https://orcid.org/0000-0001-6407-3258"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weimin Gao","raw_affiliation_strings":["Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas","Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109964925","display_name":"Chuanwen Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuanwen Lu","raw_affiliation_strings":["Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas","Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080778824","display_name":"Patrick Michael Kochanek","orcid":"https://orcid.org/0000-0002-2627-913X","observed_orcids":["https://orcid.org/0000-0002-2627-913X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Kochanek","raw_affiliation_strings":["1] Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania [2] Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania","Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania [2] Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055576189","display_name":"Rachel Pardes Berger","orcid":"https://orcid.org/0000-0001-7665-5642","observed_orcids":["https://orcid.org/0000-0001-7665-5642"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel P. Berger","raw_affiliation_strings":["1] Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania [2] Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania","Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania [2] Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073408436"],"corresponding_institution_ids":["https://openalex.org/I12315562"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":3.4493,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91609529,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"76","issue":"3","first_page":"280","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12235","display_name":"Child Abuse and Related Trauma","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12235","display_name":"Child Abuse and Related Trauma","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shaken-baby-syndrome","display_name":"shaken baby syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.703000009059906},{"id":"https://openalex.org/keywords/serum-protein-profile","display_name":"serum protein profile","score":0.5770000219345093},{"id":"https://openalex.org/keywords/injury-severity","display_name":"injury severity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/head-ct","display_name":"head CT","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.805097758769989},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6719077825546265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6617437601089478},{"id":"https://openalex.org/C3019520628","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head trauma","level":2,"score":0.6160929799079895},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.572390615940094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5118438601493835},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.49842238426208496},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42129185795783997},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4182986617088318},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3293211758136749},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17614838480949402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16380473971366882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12730711698532104},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0923791229724884},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08386257290840149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002649","descriptor_name":"Child Abuse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006259","descriptor_name":"Craniocerebral Trauma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006259","descriptor_name":"Craniocerebral Trauma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057825","descriptor_name":"Two-Dimensional Difference Gel Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/pr.2014.86","doi":"https://doi.org/10.1038/pr.2014.86","is_oa":false,"landing_page_url":"https://doi.org/10.1038/pr.2014.86","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},{"id":"pmid:24941216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24941216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4494367141","display_name":"Novel Approaches to Screening for Inflicted Childhood Neurotrauma","funder_award_id":"R01HD055986","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W64393210","https://openalex.org/W1482836384","https://openalex.org/W1505550212","https://openalex.org/W1565659347","https://openalex.org/W1894433771","https://openalex.org/W1972398761","https://openalex.org/W1972859214","https://openalex.org/W1983209719","https://openalex.org/W1983802804","https://openalex.org/W1986182250","https://openalex.org/W1986621863","https://openalex.org/W1996368246","https://openalex.org/W1997939715","https://openalex.org/W2000581941","https://openalex.org/W2003923114","https://openalex.org/W2008251088","https://openalex.org/W2010915352","https://openalex.org/W2011684274","https://openalex.org/W2016553518","https://openalex.org/W2023232598","https://openalex.org/W2032780656","https://openalex.org/W2035096359","https://openalex.org/W2037002457","https://openalex.org/W2037425720","https://openalex.org/W2042147373","https://openalex.org/W2045157582","https://openalex.org/W2045947703","https://openalex.org/W2060090974","https://openalex.org/W2061011940","https://openalex.org/W2074869825","https://openalex.org/W2078021038","https://openalex.org/W2079495871","https://openalex.org/W2081787215","https://openalex.org/W2092921862","https://openalex.org/W2093259250","https://openalex.org/W2109001629","https://openalex.org/W2113374658","https://openalex.org/W2126510214","https://openalex.org/W2126783998","https://openalex.org/W2128898409","https://openalex.org/W2137968618","https://openalex.org/W2324622279","https://openalex.org/W2324640604"],"related_works":["https://openalex.org/W4313232254","https://openalex.org/W4411922720","https://openalex.org/W2935739875","https://openalex.org/W2793362574","https://openalex.org/W2023232598","https://openalex.org/W3039198699","https://openalex.org/W1980325117","https://openalex.org/W1982624510","https://openalex.org/W4405640095","https://openalex.org/W4386271904"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}