{"id":"https://openalex.org/W1987102416","doi":"https://doi.org/10.1210/jcem-16-7-848","title":"THE METABOLISM OF IODOTYROSINES. II THE METABOLISM OF MONO- AND DI-IODOTYROSINE II CERTAIN PATIENTS WITH FAMILIAL GOITER*","display_name":"THE METABOLISM OF IODOTYROSINES. II THE METABOLISM OF MONO- AND DI-IODOTYROSINE II CERTAIN PATIENTS WITH FAMILIAL GOITER*","publication_year":1956,"publication_date":"1956-07-01","ids":{"openalex":"https://openalex.org/W1987102416","doi":"https://doi.org/10.1210/jcem-16-7-848","mag":"1987102416","pmid":"https://pubmed.ncbi.nlm.nih.gov/13332049"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-16-7-848","doi":"https://doi.org/10.1210/jcem-16-7-848","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-16-7-848","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113466605","display_name":"John Burton Stanbury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOHN B. STANBURY","raw_affiliation_strings":["The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111580415","display_name":"Jaap W. A. Meijer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. W. A. MEIJER","raw_affiliation_strings":["The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028008731","display_name":"A. A. H. Kassenaar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. H. KASSENAAR","raw_affiliation_strings":["The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Clinical Endocrinology and Metabolism, Academisch Ziekenhuis Leiden, Holland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":24.3908,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.99787279,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"7","first_page":"848","last_page":"868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deiodination","display_name":"deiodination","score":0.753000020980835},{"id":"https://openalex.org/keywords/familial-goiter","display_name":"familial goiter","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/myxedema","display_name":"myxedema","score":0.8259999752044678},{"id":"https://openalex.org/keywords/urinary-iodide","display_name":"urinary iodide","score":0.5339999794960022},{"id":"https://openalex.org/keywords/iodine-131-labeling","display_name":"iodine-131 labeling","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.7189606428146362},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.7179019451141357},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.666351318359375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6515910625457764},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6387025713920593},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6105294227600098},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6098107695579529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5842950344085693},{"id":"https://openalex.org/C2778340925","wikidata":"https://www.wikidata.org/wiki/Q410521","display_name":"Diiodotyrosine","level":4,"score":0.5246255993843079},{"id":"https://openalex.org/C2778870691","wikidata":"https://www.wikidata.org/wiki/Q44794658","display_name":"Iodide","level":2,"score":0.5164996981620789},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4908371567726135},{"id":"https://openalex.org/C2780101021","wikidata":"https://www.wikidata.org/wiki/Q966229","display_name":"Myxedema","level":3,"score":0.45939016342163086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24798443913459778},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.2128399908542633},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06867629289627075}],"mesh":[{"descriptor_ui":"D004105","descriptor_name":"Diiodotyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006042","descriptor_name":"Goiter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007470","descriptor_name":"Monoiodotyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-16-7-848","doi":"https://doi.org/10.1210/jcem-16-7-848","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-16-7-848","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:13332049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13332049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1983619943","https://openalex.org/W2003513245","https://openalex.org/W2012142122","https://openalex.org/W2016313702","https://openalex.org/W2049893596","https://openalex.org/W2165111821","https://openalex.org/W2168585131"],"related_works":["https://openalex.org/W2065595083","https://openalex.org/W2168585131","https://openalex.org/W2411937824","https://openalex.org/W2414098426","https://openalex.org/W2413686116","https://openalex.org/W2132941323","https://openalex.org/W4241127468","https://openalex.org/W1999703209","https://openalex.org/W2082819328","https://openalex.org/W2012142122"],"abstract_inverted_index":{"When":[0],"I131-labeled":[1,40],"dl-di-iodotyrosine":[2],"(T2*)":[3],"is":[4,25,43],"injected":[5],"intravenously":[6],"into":[7,14],"patients":[8],"with":[9,99],"treated":[10],"myxedema":[11],"(1)":[12],"or":[13,63,77],"normal":[15],"subjects":[16],"(2),":[17],"labeled":[18,51,74,85],"iodine":[19],"which":[20],"appears":[21,56,79],"in":[22,47,58,80,90,93],"the":[23,35,48,59,81,94],"urine":[24],"almost":[26],"entirely":[27],"inorganic":[28],"iodide.":[29],"Only":[30],"a":[31,53,97],"small":[32],"fraction":[33,55],"of":[34,50,65,96,115],"administered":[36],"T2*":[37],"escapes":[38],"deiodination.":[39],"l-mono-iodotyrosine":[41],"(T1*)":[42],"similarly":[44],"deiodinated;":[45],"but":[46],"case":[49],"d-mono-iodotyrosine,":[52],"large":[54,91],"unchanged":[57],"urine.":[60],"After":[61],"ingestion":[62],"injection":[64],"I131,":[66],"very":[67],"little":[68],"(3)":[69],"if":[70],"any":[71],"(4,":[72],"5)":[73],"free":[75],"mono-":[76],"di-iodotyrosine":[78,87],"serum.":[82],"Recently":[83],"both":[84],"mono-and":[86],"were":[88],"detected":[89],"amounts":[92],"serum":[95],"patient":[98],"hypothyroidism":[100],"and":[101],"familial":[102],"goiter":[103],"(6).":[104],"One":[105],"possible":[106],"explanation":[107],"for":[108],"this":[109],"unusual":[110],"finding":[111],"was":[112],"that":[113],"degradation":[114],"these":[116],"substances":[117],"might":[118],"be":[119],"defective.":[120]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}