{"id":"https://openalex.org/W1987069824","doi":"https://doi.org/10.1093/jnci/djh332","title":"Can Selenium Prevent Colorectal Cancer? A Signpost From Epidemiology","display_name":"Can Selenium Prevent Colorectal Cancer? A Signpost From Epidemiology","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W1987069824","doi":"https://doi.org/10.1093/jnci/djh332","mag":"1987069824","pmid":"https://pubmed.ncbi.nlm.nih.gov/15547171"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/djh332","doi":"https://doi.org/10.1093/jnci/djh332","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djh332","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079792677","display_name":"Anna J. Duffield\u2010Lillico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. J. Duffield-Lillico","raw_affiliation_strings":["Correspondence to: Scott M. Lippman, MD, Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 236, Houston, TX 77030 (","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Correspondence to: Scott M. Lippman, MD, Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 236, Houston, TX 77030 (","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020406311","display_name":"Imad Shureiqi","orcid":"https://orcid.org/0000-0003-2019-938X","observed_orcids":["https://orcid.org/0000-0003-2019-938X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Shureiqi","raw_affiliation_strings":["GI Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Medical Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111435637","display_name":"Scott M. Lippman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Lippman","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079792677"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":0.3764,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.33185841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"96","issue":"22","first_page":"1645","last_page":"1647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9559999704360962},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.753000020980835},{"id":"https://openalex.org/keywords/selenium-intake","display_name":"dietary selenium intake","score":0.7200000286102295},{"id":"https://openalex.org/keywords/selenium-supplementation","display_name":"selenium supplementation","score":0.574999988079071},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.6589999794960022},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/protective-association","display_name":"protective association","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6493126153945923},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.635220468044281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.628881573677063},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42920905351638794},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.42148369550704956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4020898938179016},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3651013672351837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32160481810569763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07442730665206909},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018036","descriptor_name":"Selenium Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018036","descriptor_name":"Selenium Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051140","descriptor_name":"Selenoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jnci/djh332","doi":"https://doi.org/10.1093/jnci/djh332","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djh332","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:15547171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15547171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Comment"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.336.4721","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.336.4721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/96/22/1645.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:jnci:96/22/1645","doi":null,"is_oa":false,"landing_page_url":"http://jnci.oxfordjournals.org/cgi/content/short/96/22/1645","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1552528612","https://openalex.org/W1657164784","https://openalex.org/W1937307285","https://openalex.org/W1949644981","https://openalex.org/W1967132242","https://openalex.org/W1991624141","https://openalex.org/W1998052180","https://openalex.org/W1998072134","https://openalex.org/W2004057805","https://openalex.org/W2007825194","https://openalex.org/W2011802015","https://openalex.org/W2014135069","https://openalex.org/W2017353544","https://openalex.org/W2037512483","https://openalex.org/W2037844120","https://openalex.org/W2041936685","https://openalex.org/W2049969105","https://openalex.org/W2055906316","https://openalex.org/W2069136008","https://openalex.org/W2080603510","https://openalex.org/W2089076146","https://openalex.org/W2093141939","https://openalex.org/W2093974632","https://openalex.org/W2103476143","https://openalex.org/W2104673157","https://openalex.org/W2105232361","https://openalex.org/W2110105767","https://openalex.org/W2116810187","https://openalex.org/W2118400439","https://openalex.org/W2119427391","https://openalex.org/W2145099286","https://openalex.org/W2149880164","https://openalex.org/W2161452781","https://openalex.org/W2163177774","https://openalex.org/W2163238032","https://openalex.org/W2181654645","https://openalex.org/W2290232260","https://openalex.org/W2312541525","https://openalex.org/W2321936981","https://openalex.org/W2328253827","https://openalex.org/W2336342927","https://openalex.org/W2339913251","https://openalex.org/W2395953724","https://openalex.org/W2396582909","https://openalex.org/W2413250869","https://openalex.org/W2988489054","https://openalex.org/W3025746616","https://openalex.org/W4206369989","https://openalex.org/W4232771318","https://openalex.org/W4245684785"],"related_works":["https://openalex.org/W2183105219","https://openalex.org/W7097112579","https://openalex.org/W2161452781","https://openalex.org/W2024772034","https://openalex.org/W3168896834","https://openalex.org/W1982397340","https://openalex.org/W2013506504","https://openalex.org/W2134749926","https://openalex.org/W2537875943","https://openalex.org/W2037844120"],"abstract_inverted_index":{"The":[0,24,78],"limited":[1],"epidemiology":[2,25],"published":[3],"heretofore":[4],"on":[5,21],"associations":[6],"between":[7,32,71],"selenium":[8,72,91,101],"and":[9,18,52,73],"colorectal":[10,74,118,161],"adenomas":[11,75],"or":[12,43,62,76],"cancer":[13,106,119],"has":[14],"been":[15,28],"mixed,":[16],"inconclusive,":[17],"based":[19],"predominantly":[20],"small":[22],"studies.":[23],"studies":[26],"have":[27],"about":[29],"evenly":[30],"split":[31],"those":[33,53],"showing":[34,54],"a":[35,55,86,95,113,121,180],"statistically":[36,114,156],"significant":[37,115,157],"(":[38,45,57,65,107,151,186],"1":[39],"\u2013":[40,59],"5":[41],")":[42,49,61,69],"suggestive":[44,63],"6":[46],",":[47,67],"7":[48],"protective":[50,88],"association":[51,70,167],"null":[56],"8":[58],"11":[60],"harmful":[64],"12":[66],"13":[68],"cancer.":[77],"strongest":[79],"(and":[80],"only":[81],"clinical)":[82],"previous":[83],"support":[84],"for":[85],"possible":[87],"effect":[89],"of":[90,100,117,172],"intake":[92],"came":[93],"from":[94],"large,":[96],"randomized":[97],"controlled":[98],"trial":[99,111,185],"in":[102,160,166,183],"preventing":[103],"nonmelanoma":[104],"skin":[105],"14":[108],").":[109,153,188],"This":[110],"showed":[112],"reduction":[116,159],"as":[120,179],"secondary":[122,181],"endpoint":[123,182],"(relative":[124],"risk":[125],"[RR]":[126],"=":[127,133,143,147],"0.58,":[128],"95%":[129,145],"confidence":[130],"interval":[131],"[CI]":[132],"0.18":[134],"to":[135,149],"0.95)":[136],"that":[137],"attenuated":[138],"after":[139],"longer":[140],"follow-up":[141],"(RR":[142],"0.45,":[144],"CI":[146],"0.19":[148],"1.08)":[150],"15":[152],"A":[154],"marginally":[155],"overall":[158],"adenomas,":[162],"which":[163],"became":[164],"stronger":[165],"with":[168],"the":[169,184],"lowest":[170],"tertile":[171],"baseline":[173],"selenium,":[174],"was":[175],"also":[176],"observed":[177],"again,":[178],"16":[187]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
