{"id":"https://openalex.org/W1987005778","doi":"https://doi.org/10.1272/manms.6.17","title":"Management of Hypertension in Patients with Chronic Kidney Disease","display_name":"Management of Hypertension in Patients with Chronic Kidney Disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1987005778","doi":"https://doi.org/10.1272/manms.6.17","mag":"1987005778"},"language":"en","primary_location":{"id":"doi:10.1272/manms.6.17","doi":"https://doi.org/10.1272/manms.6.17","is_oa":true,"landing_page_url":"https://doi.org/10.1272/manms.6.17","pdf_url":"https://www.jstage.jst.go.jp/article/manms/6/1/6_1_17/_pdf","source":{"id":"https://openalex.org/S63054412","display_name":"Nihon Ika Daigaku Igakkai Zasshi","issn_l":"1349-8975","issn":["1349-8975","1880-2877"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Ika Daigaku Igakkai Zasshi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/manms/6/1/6_1_17/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109858761","display_name":"Kouichi Utsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kouichi Utsumi","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025830520","display_name":"Akio Hirama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Hirama","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110118043","display_name":"Kae Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kae Ueda","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066816389","display_name":"Akiko Mii","orcid":"https://orcid.org/0000-0003-0326-8267","observed_orcids":["https://orcid.org/0000-0003-0326-8267"]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Mii","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100807582","display_name":"Tomohiro Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Kaneko","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112657816","display_name":"Yasuhiko Iino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Iino","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111666748","display_name":"Yasuo Katayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Katayama","raw_affiliation_strings":["Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","Department of Neurological, Nephrological, and Rheumatological Science,","Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science, Graduate School of Medicine, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Neurological, Nephrological, and Rheumatological Science,","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan","institution_ids":["https://openalex.org/I80188885"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109858761"],"corresponding_institution_ids":["https://openalex.org/I80188885"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11530547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":"17","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.16060000658035278,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8640000224113464},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.8059999942779541},{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.996999979019165},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7680000066757202},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9580000042915344},{"id":"https://openalex.org/keywords/blood-pressure-targets","display_name":"blood pressure targets","score":0.753000020980835},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.9430000185966492},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8570965528488159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8123176097869873},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7633700370788574},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.712968111038208},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6369860172271729},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.609742283821106},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.598493218421936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5203777551651001},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4135957956314087},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3608303666114807},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3236810564994812}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1272/manms.6.17","doi":"https://doi.org/10.1272/manms.6.17","is_oa":true,"landing_page_url":"https://doi.org/10.1272/manms.6.17","pdf_url":"https://www.jstage.jst.go.jp/article/manms/6/1/6_1_17/_pdf","source":{"id":"https://openalex.org/S63054412","display_name":"Nihon Ika Daigaku Igakkai Zasshi","issn_l":"1349-8975","issn":["1349-8975","1880-2877"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Ika Daigaku Igakkai Zasshi","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1272/manms.6.17","doi":"https://doi.org/10.1272/manms.6.17","is_oa":true,"landing_page_url":"https://doi.org/10.1272/manms.6.17","pdf_url":"https://www.jstage.jst.go.jp/article/manms/6/1/6_1_17/_pdf","source":{"id":"https://openalex.org/S63054412","display_name":"Nihon Ika Daigaku Igakkai Zasshi","issn_l":"1349-8975","issn":["1349-8975","1880-2877"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Ika Daigaku Igakkai Zasshi","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987005778.pdf","grobid_xml":"https://content.openalex.org/works/W1987005778.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W7558900","https://openalex.org/W2047390341","https://openalex.org/W2049397775","https://openalex.org/W2075391935","https://openalex.org/W2082069148","https://openalex.org/W2082236694","https://openalex.org/W2085618156","https://openalex.org/W2091886687","https://openalex.org/W2098944132","https://openalex.org/W2108807575","https://openalex.org/W2121969402","https://openalex.org/W2125791343","https://openalex.org/W2145632027","https://openalex.org/W2159511512"],"related_works":["https://openalex.org/W1968917996","https://openalex.org/W3007823862","https://openalex.org/W2903633667","https://openalex.org/W3084092164","https://openalex.org/W2808234993","https://openalex.org/W1970861847","https://openalex.org/W4315779885","https://openalex.org/W4379116835","https://openalex.org/W2500419501","https://openalex.org/W2036428062"],"abstract_inverted_index":{"Chronic":[0],"kidney":[1],"disease":[2,60],"(CKD)":[3],"is":[4,11,22,40,54,63,137,149],"defined":[5],"by":[6],"two":[7],"criteria.":[8],"One":[9],"criterion":[10,21],"abnormal":[12],"renal":[13,129],"function":[14],"or":[15],"morphology,":[16],"especially":[17],"proteinuria.":[18],"A":[19],"second":[20],"an":[23],"estimated":[24],"glomerular":[25],"filtration":[26],"rate":[27],"(eGFR)":[28],"less":[29,138],"than":[30,139,151],"60":[31],"mL/min/1.73m2":[32],"calculated":[33],"with":[34,73,80],"the":[35,43,98,121,133,144,155],"serum":[36],"creatinine":[37],"concentration.":[38],"CKD":[39,53,81],"classified":[41],"on":[42],"basis":[44],"of":[45,58,67,76,97,116,123,146,161],"eGFR":[46],"from":[47],"stage":[48,51],"1":[49],"to":[50,83,113],"5.":[52],"a":[55,64],"common":[56],"cause":[57,66],"cardiovascular":[59],"(CVD).":[61],"CVD":[62,85],"major":[65],"morbidity":[68],"and":[69,86,104,126,141,167],"mortality":[70],"in":[71,78,119,127],"patients":[72,79],"CKD.":[74],"Management":[75],"hypertension":[77],"aims":[82],"prevent":[84],"provide":[87],"renoprotection.":[88],"First-line":[89],"agents":[90,110,118],"for":[91],"controlling":[92],"blood":[93,135,157],"pressure":[94,136],"are":[95,111],"inhibitors":[96,103],"renin-angiotensin":[99],"system:":[100],"angiotensin-converting":[101],"enzyme":[102],"angiotensin":[105],"II":[106],"receptor":[107],"blockers.":[108],"These":[109],"superior":[112],"other":[114,159],"classes":[115,160],"antihypertensive":[117,162],"reducing":[120],"amount":[122,145],"urinary":[124,147],"protein":[125,148],"preserving":[128],"function.":[130],"In":[131],"CKD,":[132],"target":[134,156],"130/80mmHg,":[140],"125/75mmHg,":[142],"if":[143],"more":[150],"1g/day.":[152],"To":[153],"achieve":[154],"pressure,":[158],"agents,":[163],"such":[164],"as":[165],"diuretics":[166],"calcium":[168],"channel":[169],"blockers,":[170],"should":[171],"also":[172],"be":[173],"administered.":[174]},"counts_by_year":[],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2016-06-24T00:00:00"}