{"id":"https://openalex.org/W1986997114","doi":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","title":"Variability of parvovirus B19 to inactivation by liquid heating in plasma products","display_name":"Variability of parvovirus B19 to inactivation by liquid heating in plasma products","publication_year":2006,"publication_date":"2006-12-21","ids":{"openalex":"https://openalex.org/W1986997114","doi":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","mag":"1986997114","pmid":"https://pubmed.ncbi.nlm.nih.gov/17298573"},"language":"en","primary_location":{"id":"doi:10.1111/j.1423-0410.2006.00879.x","doi":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1423-0410.2006.00879.x","source":{"id":"https://openalex.org/S56953219","display_name":"Vox Sanguinis","issn_l":"0042-9007","issn":["0042-9007","1423-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vox Sanguinis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1423-0410.2006.00879.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078784961","display_name":"Shinji Hattori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Hattori","raw_affiliation_strings":["Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025721514","display_name":"Mikihiro Yunoki","orcid":"https://orcid.org/0000-0002-1548-5894","observed_orcids":["https://orcid.org/0000-0002-1548-5894"]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. Yunoki","raw_affiliation_strings":["Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan","Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113645947","display_name":"Muneo Tsujikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Tsujikawa","raw_affiliation_strings":["Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071100565","display_name":"Takeru Urayama","orcid":"https://orcid.org/0009-0001-7838-4513","observed_orcids":["https://orcid.org/0009-0001-7838-4513"]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Urayama","raw_affiliation_strings":["Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan","Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051969433","display_name":"Yuya Tachibana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Tachibana","raw_affiliation_strings":["Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Yamamoto","raw_affiliation_strings":["Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057538248","display_name":"Shogo Yamamoto","orcid":"https://orcid.org/0009-0001-8068-8620","observed_orcids":["https://orcid.org/0009-0001-8068-8620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Yamamoto","raw_affiliation_strings":["Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Pathogen Research Group, Hirakata Research Laboratory, Research & Development Division, Benesis Corporation, 2-25-1 Shodai-Ohtani, Hirakata, Osaka 573-1153, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023255479","display_name":"Kazuyoshi Ikuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ikuta","raw_affiliation_strings":["Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025721514"],"corresponding_institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.4846,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81045813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"92","issue":"2","first_page":"121","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvovirus-b19","display_name":"parvovirus B19","score":0.9909999966621399},{"id":"https://openalex.org/keywords/thermal-inactivation","display_name":"thermal inactivation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/liquid-heating","display_name":"liquid heating","score":0.8970000147819519},{"id":"https://openalex.org/keywords/plasma-derived-products","display_name":"plasma-derived products","score":0.5580000281333923},{"id":"https://openalex.org/keywords/virus-inactivation-kinetics","display_name":"virus inactivation kinetics","score":0.6579999923706055},{"id":"https://openalex.org/keywords/solution-composition","display_name":"solution composition","score":0.44600000977516174},{"id":"https://openalex.org/keywords/transfusion-safety","display_name":"transfusion safety","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2779630601","wikidata":"https://www.wikidata.org/wiki/Q13210344","display_name":"Parvovirus","level":3,"score":0.8144835233688354},{"id":"https://openalex.org/C3018445481","wikidata":"https://www.wikidata.org/wiki/Q7935312","display_name":"Virus inactivation","level":3,"score":0.546364963054657},{"id":"https://openalex.org/C2778561560","wikidata":"https://www.wikidata.org/wiki/Q13210344","display_name":"Parvoviridae","level":4,"score":0.5240507125854492},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.4129430055618286},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39020735025405884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3651062250137329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3430367112159729},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.33087772130966187},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19954916834831238},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11729943752288818},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010322","descriptor_name":"Parvoviridae Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016732","descriptor_name":"Parvovirus B19, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016913","descriptor_name":"Blood Component Transfusion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D028323","descriptor_name":"Parvovirus, Porcine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D038301","descriptor_name":"Virus Inactivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1423-0410.2006.00879.x","doi":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1423-0410.2006.00879.x","source":{"id":"https://openalex.org/S56953219","display_name":"Vox Sanguinis","issn_l":"0042-9007","issn":["0042-9007","1423-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vox Sanguinis","raw_type":"journal-article"},{"id":"pmid:17298573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17298573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vox sanguinis","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1111/j.1423-0410.2006.00879.x","doi":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1423-0410.2006.00879.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1423-0410.2006.00879.x","source":{"id":"https://openalex.org/S56953219","display_name":"Vox Sanguinis","issn_l":"0042-9007","issn":["0042-9007","1423-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vox Sanguinis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986997114.pdf","grobid_xml":"https://content.openalex.org/works/W1986997114.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1480400711","https://openalex.org/W1549635189","https://openalex.org/W1898719902","https://openalex.org/W1982260117","https://openalex.org/W1988749624","https://openalex.org/W1989069389","https://openalex.org/W1994477463","https://openalex.org/W2008241093","https://openalex.org/W2008337330","https://openalex.org/W2072951090","https://openalex.org/W2460292575"],"related_works":["https://openalex.org/W1941931039","https://openalex.org/W2008337330","https://openalex.org/W1994477463","https://openalex.org/W2004329570","https://openalex.org/W3029578808","https://openalex.org/W2072951090","https://openalex.org/W1994107851","https://openalex.org/W2076281028","https://openalex.org/W2556616215","https://openalex.org/W147696375"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,71],"OBJECTIVES:":[2],"Previously,":[3],"we":[4,47],"reported":[5],"that":[6,167],"although":[7],"human":[8],"parvovirus":[9],"B19":[10,57,89,100,122,133,189,221],"in":[11,23,58,115,134,148,156,168,172,182,193],"albumin":[12,183],"and":[13,60,83,90,151,184],"intravenous":[14,185],"immunoglobulin":[15,186],"preparations":[16,66,85,137],"was":[17,35,105,118,163,176],"rapidly":[18,180],"inactivated":[19,181],"during":[20,67,142,205],"liquid":[21,68,143,206],"heating,":[22],"contrast":[24],"to":[25,33,49,54,178,222],"other":[26],"parvoviruses":[27],"such":[28],"as":[29,107],"canine":[30],"parvovirus,":[31],"sensitivity":[32,53,219],"heat":[34,55,79,196],"highly":[36],"dependent":[37],"on":[38,199],"the":[39,42,52,174,200,203,212,218],"composition":[40,201],"of":[41,56,81,110,161,195,202,220],"solution.":[43],"In":[44],"this":[45],"study,":[46],"aimed":[48],"further":[50],"elucidate":[51],"haptoglobin":[59,82,149],"antithrombin":[61,64,84,157],"(previously":[62],"named":[63],"III)":[65],"heating.":[69,207],"MATERIALS":[70],"METHODS:":[72],"Two":[73],"different":[74,135,139,165],"solutions":[75],"collected":[76],"immediately":[77],"before":[78],"treatment":[80],"were":[86],"spiked":[87],"with":[88,126],"subsequently":[91],"treated":[92],"at":[93],"60":[94],"degrees":[95],"C":[96],"for":[97,214],"10":[98],"h.":[99],"DNA-positive,":[101],"anti-B19":[102],"IgG/IgM-negative":[103],"plasma":[104,136],"used":[106],"a":[108,121],"source":[109],"B19.":[111],"The":[112,159],"residual":[113],"infectivity":[114,124],"each":[116],"sample":[117],"measured":[119],"using":[120],"cell-based":[123],"assay":[125],"an":[127],"mRNA":[128],"polymerase":[129],"chain":[130],"reaction.":[131],"RESULTS:":[132],"showed":[138],"heat-sensitivity":[140],"patterns":[141],"heating:":[144],"(i)":[145],"slow":[146],"inactivation":[147,155,162],"preparations,":[150],"(ii)":[152],"only":[153],"limited":[154],"preparations.":[158,187],"kinetics":[160],"greatly":[164],"from":[166],"our":[169],"previous":[170],"studies":[171],"which":[173],"virus":[175],"shown":[177],"be":[179],"CONCLUSION:":[188],"has":[190],"unique":[191],"properties":[192],"terms":[194],"sensitivity,":[197],"depending":[198],"solution":[204],"This":[208],"finding":[209],"may":[210],"indicate":[211],"need":[213],"caution":[215],"when":[216],"interpreting":[217],"heat.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
