{"id":"https://openalex.org/W1986991287","doi":"https://doi.org/10.1139/y88-138","title":"Membrane responses of neurons in human sympathetic ganglia","display_name":"Membrane responses of neurons in human sympathetic ganglia","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W1986991287","doi":"https://doi.org/10.1139/y88-138","mag":"1986991287","pmid":"https://pubmed.ncbi.nlm.nih.gov/3167700"},"language":"en","primary_location":{"id":"doi:10.1139/y88-138","doi":"https://doi.org/10.1139/y88-138","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y88-138","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035697909","display_name":"E. Puil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E. Puil","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012322910","display_name":"Hossam El\u2010Beheiry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. El-Beheiry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007512998","display_name":"Igor Spigelman","orcid":"https://orcid.org/0000-0001-6489-5454","observed_orcids":["https://orcid.org/0000-0001-6489-5454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Spigelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1318,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.39195803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"6","first_page":"853","last_page":"857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sympathetic-ganglion-neurons","display_name":"sympathetic ganglion cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/input-resistance","display_name":"input resistance","score":0.6859999895095825},{"id":"https://openalex.org/keywords/resting-membrane-potential","display_name":"resting membrane potential","score":0.7799999713897705},{"id":"https://openalex.org/keywords/membrane-time-constant","display_name":"membrane time constant","score":0.9449999928474426},{"id":"https://openalex.org/keywords/spike-duration","display_name":"spike length","score":0.3799999952316284},{"id":"https://openalex.org/keywords/tetrodotoxin-sensitivity","display_name":"tetrodotoxin sensitivity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.9350000023841858},{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9459999799728394},{"id":"https://openalex.org/keywords/repetitive-firing","display_name":"repetitive firing","score":0.7210000157356262},{"id":"https://openalex.org/keywords/in-vitro-slice-preparation","display_name":"in vitro slice preparation","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.7709829807281494},{"id":"https://openalex.org/C2781295685","wikidata":"https://www.wikidata.org/wiki/Q410728","display_name":"Tetraethylammonium","level":3,"score":0.7175058126449585},{"id":"https://openalex.org/C2780922449","wikidata":"https://www.wikidata.org/wiki/Q372539","display_name":"4-Aminopyridine","level":3,"score":0.7032042145729065},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.6721498966217041},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6142369508743286},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5563929677009583},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5436474680900574},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.5155460834503174},{"id":"https://openalex.org/C29694410","wikidata":"https://www.wikidata.org/wiki/Q7540236","display_name":"Slice preparation","level":3,"score":0.5080509185791016},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.483391672372818},{"id":"https://openalex.org/C2777646271","wikidata":"https://www.wikidata.org/wiki/Q3554908","display_name":"Sympathetic ganglion","level":2,"score":0.4773183763027191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44608137011528015},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.42854025959968567},{"id":"https://openalex.org/C2780918503","wikidata":"https://www.wikidata.org/wiki/Q7706336","display_name":"Tetraethylammonium chloride","level":3,"score":0.4269551932811737},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42245206236839294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3670046329498291},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3189946115016937},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.31428951025009155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3096981644630432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.257967472076416},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.08203354477882385},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000632","descriptor_name":"Aminopyrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005728","descriptor_name":"Ganglia, Sympathetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013757","descriptor_name":"Tetraethylammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/y88-138","doi":"https://doi.org/10.1139/y88-138","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y88-138","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:3167700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3167700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W317017184","https://openalex.org/W1649735321","https://openalex.org/W1975625520","https://openalex.org/W1988863515","https://openalex.org/W1997825378","https://openalex.org/W2009593799","https://openalex.org/W2023854588","https://openalex.org/W2040934669","https://openalex.org/W2048729800","https://openalex.org/W2048747981","https://openalex.org/W2063138566","https://openalex.org/W2084461841","https://openalex.org/W2094618156","https://openalex.org/W2112775014","https://openalex.org/W2238055836"],"related_works":["https://openalex.org/W2014949596","https://openalex.org/W2411105289","https://openalex.org/W1966440335","https://openalex.org/W2069899369","https://openalex.org/W2048567037","https://openalex.org/W2112775014","https://openalex.org/W1988863515","https://openalex.org/W2079442777","https://openalex.org/W1993681669","https://openalex.org/W2086624498"],"abstract_inverted_index":{"Electrophysiological":[0],"studies":[1],"were":[2,68,83,87],"performed":[3],"on":[4],"in":[5,22,32,39,59,90,119,131,167,168],"vitro":[6,169],"slice":[7],"preparations":[8],"of":[9,70,99],"sympathetic":[10,37,138,160],"ganglia":[11],"excised":[12],"from":[13],"peripherally":[14],"perfused,":[15],"brain-dead":[16],"human":[17,159,180],"donors.":[18],"The":[19,42],"intracellular":[20],"recordings":[21],"16":[23],"neurons":[24,38,61,162],"showed":[25],"resting":[26],"potentials":[27],"and":[28,86,171],"input":[29,44],"resistances":[30,45],"mostly":[31],"the":[33,53,111,132,144,155,179],"ranges":[34],"reported":[35],"for":[36,52,154,175],"other":[40],"mammals.":[41],"high":[43],"(approximately":[46],"29":[47],"M":[48],"omega)":[49],"can":[50,163],"account":[51],"long":[54],"membrane":[55,112],"time":[56,157],"constants":[57],"measured":[58],"three":[60],"(means":[62],"=":[63],"13.9":[64],"ms).":[65],"Spikes":[66],"that":[67,136,158],"part":[69],"anodal":[71],"break":[72],"responses":[73],"as":[74,76,128,130],"well":[75,129],"those":[77],"evoked":[78,123],"by":[79,92,95,105,124],"current":[80,125],"pulse":[81,126],"injections":[82,127],"tetrodotoxin":[84],"sensitive":[85],"more":[88],"prolonged":[89],"duration":[91],"tetraethylammonium":[93],"than":[94],"4-aminopyridine":[96],"applications.":[97],"Administrations":[98],"isoflurane":[100,149],"(0.5-2":[101],"minimum":[102],"alveolar":[103],"concentrations)":[104],"perfusion":[106],"did":[107],"not":[108],"greatly":[109],"affect":[110],"properties,":[113],"but":[114],"produced":[115],"a":[116,137],"marked":[117],"reduction":[118],"repetitive":[120],"spike":[121],"firing":[122],"postspike":[133],"afterhyperpolarizations,":[134],"suggesting":[135],"neurogenic":[139],"mechanism":[140],"may":[141],"contribute":[142],"to":[143,178],"hypotension":[145],"observed":[146],"clinically":[147],"during":[148],"anaesthesia.":[150],"These":[151],"investigations":[152],"demonstrate":[153],"first":[156],"ganglion":[161],"be":[164],"studied":[165],"successfully":[166],"preparations,":[170],"hence":[172],"are":[173],"valuable":[174],"direct":[176],"relevance":[177],"condition.":[181]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}