{"id":"https://openalex.org/W1986914980","doi":"https://doi.org/10.1586/14737159.2014.965685","title":"FHACT: the FISH-based HPV-associated cancer test that detects nonrandom gain at four genomic loci as biomarkers of disease progression","display_name":"FHACT: the FISH-based HPV-associated cancer test that detects nonrandom gain at four genomic loci as biomarkers of disease progression","publication_year":2014,"publication_date":"2014-10-11","ids":{"openalex":"https://openalex.org/W1986914980","doi":"https://doi.org/10.1586/14737159.2014.965685","mag":"1986914980","pmid":"https://pubmed.ncbi.nlm.nih.gov/25308338"},"language":"en","primary_location":{"id":"doi:10.1586/14737159.2014.965685","doi":"https://doi.org/10.1586/14737159.2014.965685","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737159.2014.965685","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052154203","display_name":"Jane Houldsworth","orcid":"https://orcid.org/0000-0002-6781-1700","observed_orcids":["https://orcid.org/0000-0002-6781-1700"]},"institutions":[{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jane Houldsworth","raw_affiliation_strings":["Cancer Genetics, Inc., 201 Route 17 North, Rutherford, NJ 07070, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Inc., 201 Route 17 North, Rutherford, NJ 07070, USA","institution_ids":["https://openalex.org/I4210145812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052154203"],"corresponding_institution_ids":["https://openalex.org/I4210145812"],"apc_list":null,"apc_paid":null,"fwci":0.501,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6815237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"14","issue":"8","first_page":"921","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/20q13","display_name":"20q13","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-progression-biomarkers","display_name":"disease progression biomarkers","score":0.9089999794960022},{"id":"https://openalex.org/keywords/secondary-screening","display_name":"secondary screening","score":0.47699999809265137},{"id":"https://openalex.org/keywords/cytological-specimens","display_name":"cytology specimens","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hpv-associated-cancers","display_name":"HPV-associated cancers","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6373956203460693},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6262326836585999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.570955216884613},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5618112087249756},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5420781373977661},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4285694658756256},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.41992855072021484},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33346444368362427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32839059829711914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28249090909957886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2602280378341675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25321757793426514}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1586/14737159.2014.965685","doi":"https://doi.org/10.1586/14737159.2014.965685","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737159.2014.965685","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:25308338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25308338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of molecular diagnostics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W13130851","https://openalex.org/W1506727538","https://openalex.org/W1520483630","https://openalex.org/W1536780471","https://openalex.org/W1537810699","https://openalex.org/W1576669476","https://openalex.org/W1586041329","https://openalex.org/W1846382102","https://openalex.org/W1963744267","https://openalex.org/W1968458071","https://openalex.org/W1971083183","https://openalex.org/W1977874696","https://openalex.org/W1981661206","https://openalex.org/W1983263829","https://openalex.org/W1983410349","https://openalex.org/W1985778500","https://openalex.org/W1993857331","https://openalex.org/W1997762684","https://openalex.org/W1997917704","https://openalex.org/W1998248450","https://openalex.org/W1999658260","https://openalex.org/W1999869926","https://openalex.org/W2001294325","https://openalex.org/W2003268750","https://openalex.org/W2003473150","https://openalex.org/W2006323266","https://openalex.org/W2007719019","https://openalex.org/W2012016836","https://openalex.org/W2018429811","https://openalex.org/W2019582069","https://openalex.org/W2023410485","https://openalex.org/W2029519393","https://openalex.org/W2034269086","https://openalex.org/W2036758349","https://openalex.org/W2040034979","https://openalex.org/W2051711587","https://openalex.org/W2054603798","https://openalex.org/W2055807540","https://openalex.org/W2055810034","https://openalex.org/W2066332001","https://openalex.org/W2071848600","https://openalex.org/W2073870471","https://openalex.org/W2075379794","https://openalex.org/W2086256126","https://openalex.org/W2092880909","https://openalex.org/W2093748574","https://openalex.org/W2097981379","https://openalex.org/W2098765233","https://openalex.org/W2100774131","https://openalex.org/W2100816068","https://openalex.org/W2102402099","https://openalex.org/W2107726182","https://openalex.org/W2112304105","https://openalex.org/W2112859230","https://openalex.org/W2114000644","https://openalex.org/W2114418380","https://openalex.org/W2117300924","https://openalex.org/W2118860200","https://openalex.org/W2119613560","https://openalex.org/W2121577832","https://openalex.org/W2122314493","https://openalex.org/W2129316684","https://openalex.org/W2132203954","https://openalex.org/W2134564320","https://openalex.org/W2149347081","https://openalex.org/W2150580901","https://openalex.org/W2154082940","https://openalex.org/W2156556871","https://openalex.org/W2159440113","https://openalex.org/W2160798251","https://openalex.org/W2162055169","https://openalex.org/W2322946647","https://openalex.org/W2327814204"],"related_works":["https://openalex.org/W1537019726","https://openalex.org/W2890671950","https://openalex.org/W2282902251","https://openalex.org/W2075379794","https://openalex.org/W2162055169","https://openalex.org/W3169596969","https://openalex.org/W2945093880","https://openalex.org/W7134056275","https://openalex.org/W2085452848","https://openalex.org/W4307299190"],"abstract_inverted_index":{"Despite":[0],"implementation":[1],"of":[2,30,82,85,102,141],"screening":[3,129],"programs":[4],"for":[5,37,63],"human":[6],"papillomavirus":[7],"(HPV)-associated":[8],"cancers,":[9,52],"in":[10,113,121,138],"particular":[11],"cervical,":[12],"scientific":[13],"studies":[14],"continue":[15],"to":[16,25,71],"uncover":[17],"viral":[18],"and":[19,146],"host":[20,43],"biomarkers":[21],"that":[22,73,99],"could":[23,136],"serve":[24,78],"further":[26],"optimize":[27],"the":[28,89,92,131,139],"detection":[29,101,140],"individuals":[31],"with":[32,54,58],"underlying":[33],"or":[34,40],"at":[35,105],"risk":[36],"developing":[38],"precancer":[39],"cancer.":[41,87],"Nonrandom":[42],"somatic":[44],"chromosomal":[45],"alterations":[46],"are":[47],"frequently":[48],"shared":[49],"across":[50],"HPV-associated":[51,94,133,144],"but":[53],"varying":[55],"frequencies,":[56],"potentially":[57],"functional":[59],"roles.":[60],"At":[61],"least":[62],"3q26":[64],"gain,":[65],"there":[66],"is":[67,97],"firm":[68],"preliminary":[69],"evidence":[70],"support":[72],"this":[74],"genomic":[75,103],"alteration":[76],"can":[77],"as":[79,126],"a":[80,114,118,127],"biomarker":[81],"disease":[83,145],"progression":[84],"cervical":[86],"In":[88],"current":[90],"review,":[91],"FISH-based":[93,132],"cancer":[95,134],"test":[96,135],"described":[98],"enables":[100],"imbalance":[104],"four":[106],"loci":[107],"(3q26,":[108],"5p15,":[109],"20q13,":[110],"centromere":[111],"7)":[112],"single":[115],"hybridization":[116],"on":[117],"cell-by-cell":[119],"basis":[120],"cytology":[122],"specimens.":[123],"When":[124],"implemented":[125],"secondary":[128],"assay,":[130],"assist":[137],"clinically":[142],"relevant":[143],"help":[147],"guide":[148],"patient":[149],"management":[150],"decisions.":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
