{"id":"https://openalex.org/W1986806711","doi":"https://doi.org/10.1371/journal.ppat.1000356","title":"Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters","display_name":"Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters","publication_year":2009,"publication_date":"2009-03-26","ids":{"openalex":"https://openalex.org/W1986806711","doi":"https://doi.org/10.1371/journal.ppat.1000356","mag":"1986806711","pmid":"https://pubmed.ncbi.nlm.nih.gov/19325883"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1000356","doi":"https://doi.org/10.1371/journal.ppat.1000356","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000356","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000356&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000356&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043695299","display_name":"Sarah Dickerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Dickerson","raw_affiliation_strings":["McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052217265","display_name":"Yongna Xing","orcid":"https://orcid.org/0000-0002-9834-528X","observed_orcids":["https://orcid.org/0000-0002-9834-528X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongna Xing","raw_affiliation_strings":["McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069667474","display_name":"Amanda R. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda R. Robinson","raw_affiliation_strings":["McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049809413","display_name":"William T. Seaman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Seaman","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076709957","display_name":"Henri Gruffat","orcid":"https://orcid.org/0000-0002-4735-6894","observed_orcids":["https://orcid.org/0000-0002-4735-6894"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Henri Gruffat","raw_affiliation_strings":["Laboratoire de Virologie U758, ENS-Lyon, INSERM, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Virologie U758, ENS-Lyon, INSERM, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028943143","display_name":"Shannon C. Kenney","orcid":"https://orcid.org/0000-0002-9655-6526","observed_orcids":["https://orcid.org/0000-0002-9655-6526"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon C. Kenney","raw_affiliation_strings":["McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory, Departments of Oncology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028943143"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":5.3709,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.96368468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"3","first_page":"e1000356","last_page":"e1000356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bzlf1","display_name":"BZLF1","score":0.968999981880188},{"id":"https://openalex.org/keywords/z-protein","display_name":"Z protein","score":0.6000000238418579},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.6340000033378601},{"id":"https://openalex.org/keywords/brlf1","display_name":"BRLF1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/latency","display_name":"latency","score":0.5680000185966492},{"id":"https://openalex.org/keywords/lytic-reactivation","display_name":"lytic reactivation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/viral-transcriptional-activation","display_name":"viral transcriptional activation","score":0.4659999907016754},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2781295983","wikidata":"https://www.wikidata.org/wiki/Q19903649","display_name":"BZLF1","level":5,"score":0.8750709295272827},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6671925783157349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6309629678726196},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6140730977058411},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5429257750511169},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4513489603996277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38326501846313477},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3324744403362274},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23417946696281433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20251280069351196},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.0},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1000356","doi":"https://doi.org/10.1371/journal.ppat.1000356","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000356","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000356&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:19325883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19325883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:t435gn259","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/mhja-j058","pdf_url":"https://doi.org/10.17615/mhja-j058","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 5(3)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:1414543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.5162","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.5162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6e/cf/ppat.1000356.PMC2654727.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8f261fa6325e48f2a2f688a2e99484ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f261fa6325e48f2a2f688a2e99484ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 5, Iss 3, p e1000356 (2009)","raw_type":"article"},{"id":"doi:10.17615/mhja-j058","doi":"https://doi.org/10.17615/mhja-j058","is_oa":true,"landing_page_url":"https://doi.org/10.17615/mhja-j058","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1000356","doi":"https://doi.org/10.1371/journal.ppat.1000356","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000356","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000356&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2792961208","display_name":null,"funder_award_id":"5-P01-CA022443","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G636222781","display_name":null,"funder_award_id":"5-P01-CA-19014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7505140584","display_name":null,"funder_award_id":"P01-CA022443","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7599761654","display_name":null,"funder_award_id":"R01 CA058853","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000148496","display_name":null,"funder_award_id":"CA19014","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000223128","display_name":null,"funder_award_id":"P01-CA022443","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000330056","display_name":null,"funder_award_id":"CA022443","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880694","display_name":"Viral Oncogenesis, Latency, and Replication","funder_award_id":"P01CA019014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986806711.pdf","grobid_xml":"https://content.openalex.org/works/W1986806711.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1549534767","https://openalex.org/W1740200836","https://openalex.org/W1821654469","https://openalex.org/W1823218897","https://openalex.org/W1841083068","https://openalex.org/W1882424684","https://openalex.org/W1924232164","https://openalex.org/W1967863146","https://openalex.org/W1968916768","https://openalex.org/W1975791071","https://openalex.org/W1976337084","https://openalex.org/W1981554930","https://openalex.org/W1981785841","https://openalex.org/W2000584697","https://openalex.org/W2009173868","https://openalex.org/W2011993572","https://openalex.org/W2017086224","https://openalex.org/W2022707315","https://openalex.org/W2022980904","https://openalex.org/W2029101025","https://openalex.org/W2033768471","https://openalex.org/W2052516925","https://openalex.org/W2057749060","https://openalex.org/W2062434608","https://openalex.org/W2063411863","https://openalex.org/W2064065183","https://openalex.org/W2072609073","https://openalex.org/W2077910054","https://openalex.org/W2081154388","https://openalex.org/W2091658754","https://openalex.org/W2094144752","https://openalex.org/W2099861854","https://openalex.org/W2101134171","https://openalex.org/W2114349065","https://openalex.org/W2114758061","https://openalex.org/W2115159794","https://openalex.org/W2119642082","https://openalex.org/W2123029438","https://openalex.org/W2123711411","https://openalex.org/W2124777581","https://openalex.org/W2128317694","https://openalex.org/W2129754994","https://openalex.org/W2131484652","https://openalex.org/W2138441377","https://openalex.org/W2140097637","https://openalex.org/W2143464311","https://openalex.org/W2152316252","https://openalex.org/W2153782423","https://openalex.org/W2226175820","https://openalex.org/W2298027515","https://openalex.org/W2399880284"],"related_works":["https://openalex.org/W2122749747","https://openalex.org/W2593082157","https://openalex.org/W2319719654","https://openalex.org/W3030415692","https://openalex.org/W3029869920","https://openalex.org/W2107800932","https://openalex.org/W1483014916","https://openalex.org/W2098306094","https://openalex.org/W2116078904","https://openalex.org/W1879683751"],"abstract_inverted_index":{"The":[0,196],"switch":[1],"between":[2],"latent":[3,136,216],"and":[4,37,50,69,115,154,207,240],"lytic":[5,257],"Epstein-Barr":[6],"virus":[7,286],"(EBV)":[8],"infection":[9],"is":[10,62,83,187,235,267,276],"mediated":[11],"by":[12,121],"the":[13,34,47,71,75,84,100,105,124,142,184,226,241,244,264,272,285],"viral":[14,40,253,265,274],"immediate-early":[15],"(IE)":[16],"protein,":[17],"BZLF1":[18],"(Z).":[19],"Z,":[20],"a":[21,53],"homologue":[22],"of":[23,33,46,60,74,104,148,222,243],"c-jun":[24],"that":[25,99,117],"binds":[26],"to":[27,65,89,167,173,183,192,225,231,251,287],"AP1-like":[28],"motifs":[29],"(ZREs),":[30],"induces":[31],"expression":[32,212],"BRLF1":[35,76],"(R)":[36],"BRRF1":[38,107],"(Na)":[39],"proteins,":[41],"which":[42,163],"cooperatively":[43],"activate":[44,200],"transcription":[45,103],"Z":[48,61,122,139,159,171,181,190,223,238,245,249,280],"promoter":[49,77,87,101],"thereby":[51],"establish":[52,288],"positive":[54],"autoregulatory":[55],"loop.":[56],"A":[57],"unique":[58],"feature":[59],"its":[63],"ability":[64],"preferentially":[66],"bind":[67],"to,":[68],"activate,":[70],"methylated":[72,125,132,174,193,201,227],"form":[73,147],"(Rp).":[78],"To":[79],"date,":[80],"however,":[81],"Rp":[82],"only":[85,119],"EBV":[86,137,217],"known":[88],"be":[90,168],"regulated":[91],"in":[92,123,133,150,176,203,213,259],"this":[93],"unusual":[94],"manner.":[95],"We":[96],"now":[97],"demonstrate":[98],"driving":[102],"early":[106],"gene":[108,152,205],"(Nap)":[109],"has":[110],"two":[111],"CpG-containing":[112],"ZREs":[113,129,156,175,229],"(ACGCTCA":[114],"TCGCCCG)":[116],"are":[118,130,157],"bound":[120,224],"state.":[126],"Both":[127],"Nap":[128,149,194,202,228],"highly":[131],"cells":[134,214],"with":[135,215],"infection.":[138,218,291],"efficiently":[140],"activates":[141],"methylated,":[143],"but":[144,178],"not":[145,179,209],"unmethylated,":[146,278],"reporter":[151,204],"assays,":[153],"both":[155],"required.":[158],"serine":[160],"residue":[161],"186,":[162],"was":[164],"previously":[165],"shown":[166],"required":[169,188,236],"for":[170,180,189,237],"binding":[172,182,191,250],"Rp,":[177],"AP1":[185],"site,":[186],"ZREs.":[195],"Z(S186A)":[197],"mutant":[198],"cannot":[199],"assays":[206],"does":[208],"induce":[210],"Na":[211],"Molecular":[219],"modeling":[220],"studies":[221],"help":[230,284],"explain":[232],"why":[233],"methylation":[234],"binding,":[239],"role":[242],"Ser186":[246],"residue.":[247],"Methylation-dependent":[248],"critical":[252],"promoters":[254],"may":[255,282],"enhance":[256],"reactivation":[258],"latently":[260],"infected":[261],"cells,":[262],"where":[263],"genome":[266,275],"heavily":[268],"methylated.":[269],"Conversely,":[270],"since":[271],"incoming":[273],"initially":[277],"methylation-dependent":[279],"activation":[281],"also":[283],"latency":[289],"following":[290]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
