{"id":"https://openalex.org/W1986706264","doi":"https://doi.org/10.1159/000082081","title":"Biological Implications of Mycobacterium leprae Gene Expression during Infection","display_name":"Biological Implications of Mycobacterium leprae Gene Expression during Infection","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1986706264","doi":"https://doi.org/10.1159/000082081","mag":"1986706264","pmid":"https://pubmed.ncbi.nlm.nih.gov/15741741"},"language":"en","primary_location":{"id":"doi:10.1159/000082081","doi":"https://doi.org/10.1159/000082081","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000082081","pdf_url":null,"source":{"id":"https://openalex.org/S4210238798","display_name":"Microbial Physiology","issn_l":"2673-1665","issn":["2673-1665","2673-1673"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048716738","display_name":"Diana Lynn Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I4210143395","display_name":"National Hansen's Disease Program","ror":"https://ror.org/049n6n725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I23874457","https://openalex.org/I4210143395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana L. Williams","raw_affiliation_strings":["Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA. dwill21@lsu.edu","Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA. dwill21@lsu.edu","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I4210143395"]},{"raw_affiliation_string":"Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I4210143395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020458885","display_name":"Marina N. Torrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Torrero","raw_affiliation_strings":["Department of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, La., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, La., USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010868387","display_name":"Paul Robert Wheeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul R. Wheeler","raw_affiliation_strings":["Tuberculosis Research Unit, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuberculosis Research Unit, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020207042","display_name":"Richard W. Truman","orcid":"https://orcid.org/0000-0002-9163-7677","observed_orcids":["https://orcid.org/0000-0002-9163-7677"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I4210143395","display_name":"National Hansen's Disease Program","ror":"https://ror.org/049n6n725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I23874457","https://openalex.org/I4210143395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Truman","raw_affiliation_strings":["Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I4210143395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031329201","display_name":"Mark A. Yoder","orcid":"https://orcid.org/0009-0001-7337-9969","observed_orcids":["https://orcid.org/0009-0001-7337-9969"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Yoder","raw_affiliation_strings":["Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, and","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Norman Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Morrison","raw_affiliation_strings":["Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, and","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089421422","display_name":"William R. Bishai","orcid":"https://orcid.org/0000-0002-8734-4118","observed_orcids":["https://orcid.org/0000-0002-8734-4118"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Bishai","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Md., USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111861277","display_name":"Thomas Phillip Gillis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I4210143395","display_name":"National Hansen's Disease Program","ror":"https://ror.org/049n6n725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I23874457","https://openalex.org/I4210143395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Gillis","raw_affiliation_strings":["Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Research Branch, Division of the National Hansen's Disease Programs at LSU-SVM,","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I4210143395"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4749,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.81477014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"58","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":1.0},{"id":"https://openalex.org/keywords/leprosy","display_name":"leprosy","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pseudogenes","display_name":"pseudogenes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/multibacillary-leprosy","display_name":"multibacillary leprosy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fatty-acid-degradation","display_name":"fatty acid degradation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sigma-factor","display_name":"sigma factor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/virulence-genes","display_name":"virulence genes","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8016290664672852},{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.790369987487793},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.750359296798706},{"id":"https://openalex.org/C2779823659","wikidata":"https://www.wikidata.org/wiki/Q155891","display_name":"Mycobacterium leprae","level":3,"score":0.7162449359893799},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.634556770324707},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5638585686683655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48910313844680786},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.44685062766075134},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.14772897958755493},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.10093769431114197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007918","descriptor_name":"Leprosy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007918","descriptor_name":"Leprosy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009166","descriptor_name":"Mycobacterium leprae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009166","descriptor_name":"Mycobacterium leprae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000082081","doi":"https://doi.org/10.1159/000082081","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000082081","pdf_url":null,"source":{"id":"https://openalex.org/S4210238798","display_name":"Microbial Physiology","issn_l":"2673-1665","issn":["2673-1665","2673-1673"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Physiology","raw_type":"journal-article"},{"id":"pmid:15741741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15741741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular microbiology and biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4166532524","display_name":"DEVELOP AND EVALUATE NEW LEPROSY AND TB VACCINES","funder_award_id":"R01AI045725","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4261697682","display_name":null,"funder_award_id":"AI2646","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W122882057","https://openalex.org/W175000778","https://openalex.org/W195805106","https://openalex.org/W204070872","https://openalex.org/W1410528006","https://openalex.org/W1557707473","https://openalex.org/W1628484149","https://openalex.org/W1864461701","https://openalex.org/W1938998220","https://openalex.org/W1950875084","https://openalex.org/W1958512527","https://openalex.org/W1961207913","https://openalex.org/W1980530950","https://openalex.org/W1984329870","https://openalex.org/W1987767333","https://openalex.org/W1990755363","https://openalex.org/W2002130870","https://openalex.org/W2003384103","https://openalex.org/W2007097682","https://openalex.org/W2009839150","https://openalex.org/W2034358979","https://openalex.org/W2035651986","https://openalex.org/W2038709060","https://openalex.org/W2066857552","https://openalex.org/W2073347639","https://openalex.org/W2076420407","https://openalex.org/W2078248420","https://openalex.org/W2091405739","https://openalex.org/W2096606273","https://openalex.org/W2103771605","https://openalex.org/W2106921386","https://openalex.org/W2106942635","https://openalex.org/W2107443178","https://openalex.org/W2115138998","https://openalex.org/W2116738290","https://openalex.org/W2122234647","https://openalex.org/W2122794951","https://openalex.org/W2133365276","https://openalex.org/W2137930295","https://openalex.org/W2142272496","https://openalex.org/W2143538758","https://openalex.org/W2145061594","https://openalex.org/W2152770371","https://openalex.org/W2156610233","https://openalex.org/W2157638040","https://openalex.org/W2164217177","https://openalex.org/W2165539745","https://openalex.org/W2166410484","https://openalex.org/W2171091522","https://openalex.org/W2409219847","https://openalex.org/W2443996442"],"related_works":["https://openalex.org/W4205904762","https://openalex.org/W2073970026","https://openalex.org/W2316545038","https://openalex.org/W2106823660","https://openalex.org/W2769039162","https://openalex.org/W1973092774","https://openalex.org/W2888888553","https://openalex.org/W3026059252","https://openalex.org/W2092233856","https://openalex.org/W7010354437"],"abstract_inverted_index":{"The":[0],"genome":[1,17,27,44],"of":[2,8,28,41,62,157,164,181,200,202,213,237,244,272,275],"Mycobacterium":[3],"leprae,":[4],"the":[5,26,29,48,53,161,179,241,245,273],"etiologic":[6],"agent":[7],"leprosy,":[9],"has":[10],"been":[11],"sequenced":[12],"and":[13,21,45,74,103,134,136,176,187,217,261],"annotated":[14],"revealing":[15],"a":[16,42,154,268],"in":[18,22,59,77,93,120,172,178,194],"apparent":[19],"disarray":[20],"stark":[23],"contrast":[24],"to":[25,267,278],"related":[30],"human":[31],"pathogen,":[32],"M.":[33,90,145,195,208,251,276],"tuberculosis.":[34,196],"With":[35],"less":[36],"than":[37],"50%":[38],"coding":[39],"capacity":[40],"3.3-Mb":[43],"1,116":[46],"pseudogenes,":[47],"remaining":[49],"genes":[50,69,81,118,137,183,190,204,257],"help":[51],"define":[52],"minimal":[54],"gene":[55,87,228,253],"set":[56],"necessary":[57],"for":[58,72,111,151,233,250],"vivo":[60],"survival":[61,262],"this":[63],"mycobacterial":[64],"pathogen":[65],"as":[66,68],"well":[67],"potentially":[70],"required":[71],"infection":[73,248,264],"pathogenesis":[75],"seen":[76],"leprosy.":[78],"To":[79],"identify":[80],"transcribed":[82],"during":[83,263],"infection,":[84],"we":[85],"surveyed":[86],"transcripts":[88],"from":[89,207,211],"leprae":[91,146,209,252,277],"growing":[92],"athymic":[94],"nude":[95,219],"mice":[96],"using":[97,224],"reverse":[98],"transcriptase-polymerase":[99],"chain":[100],"reaction":[101],"(RT-PCR)":[102],"cross-species":[104],"DNA":[105,121],"microarray":[106],"technologies.":[107],"Transcripts":[108],"were":[109,205,231],"detected":[110],"221":[112],"open":[113],"reading":[114],"frames,":[115],"which":[116],"included":[117],"involved":[119,171],"replication,":[122],"cell":[123],"division,":[124],"SecA-dependent":[125],"protein":[126],"secretion,":[127],"energy":[128],"production,":[129],"intermediary":[130],"metabolism,":[131],"iron":[132,173,185],"transport":[133],"storage":[135,175],"associated":[138,191,258],"with":[139,192,259],"virulence.":[140],"These":[141],"results":[142],"suggest":[143],"that":[144],"actively":[147],"catabolizes":[148],"fatty":[149],"acids":[150],"energy,":[152],"produces":[153,168],"large":[155],"number":[156],"secretory":[158],"proteins,":[159],"utilizes":[160],"full":[162],"array":[163],"sigma":[165],"factors":[166],"available,":[167],"several":[169,189],"proteins":[170],"transport,":[174],"regulation":[177],"absence":[180],"recognizable":[182],"encoding":[184],"scavengers":[186],"transcribes":[188],"virulence":[193],"When":[197],"transcript":[198,229],"levels":[199,230],"9":[201],"these":[203,238],"compared":[206],"derived":[210],"lesions":[212],"multibacillary":[214],"leprosy":[215],"patients":[216],"infected":[218],"mouse":[220],"foot":[221,246],"pad":[222,247],"tissue":[223],"quantitative":[225],"real-time":[226],"RT-PCR,":[227],"comparable":[232],"all":[234],"but":[235],"one":[236],"genes,":[239],"supporting":[240],"continued":[242],"use":[243],"model":[249],"expression":[254],"profiling.":[255],"Identifying":[256],"growth":[260],"should":[265],"lead":[266],"more":[269],"comprehensive":[270],"understanding":[271],"ability":[274],"cause":[279],"disease.":[280]},"counts_by_year":[{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
