{"id":"https://openalex.org/W198665172","doi":null,"title":"The role of amphoterin-induced gene and open reading frame (AMIGO) family in myelination and neurodegeneration and Investigating the roles of mesenchymal and hematopoieticstem cell conditioned media on neutrophil recruitment in amodel of inflammation","display_name":"The role of amphoterin-induced gene and open reading frame (AMIGO) family in myelination and neurodegeneration and Investigating the roles of mesenchymal and hematopoieticstem cell conditioned media on neutrophil recruitment in amodel of inflammation","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W198665172","mag":"198665172"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:4585","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","pdf_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009887112","display_name":"Joseph Tickle","orcid":"https://orcid.org/0000-0003-2089-274X","observed_orcids":["https://orcid.org/0000-0003-2089-274X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Tickle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009887112"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.14429999887943268,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.871999979019165},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":1.0},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.8529999852180481},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion-molecules","display_name":"endothelial adhesion molecules","score":0.6269999742507935},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.765999972820282},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/madcam-1","display_name":"MAdCAM-1","score":0.972000002861023},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3889999985694885},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5889999866485596},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6859270334243774},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5535898804664612},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5196260809898376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5055267810821533},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46574389934539795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45395487546920776},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42043784260749817},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3560105562210083}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:4585","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","pdf_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:198665172","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:4585","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","pdf_url":"http://etheses.bham.ac.uk/4585/1/Tickle13MRes.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W198665172.pdf","grobid_xml":"https://content.openalex.org/works/W198665172.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W276203385","https://openalex.org/W1539145460","https://openalex.org/W1539565972","https://openalex.org/W1558134194","https://openalex.org/W1559848422","https://openalex.org/W1570302914","https://openalex.org/W1574813722","https://openalex.org/W1602437032","https://openalex.org/W1631250427","https://openalex.org/W1866034006","https://openalex.org/W1895115148","https://openalex.org/W1922918425","https://openalex.org/W1963668888","https://openalex.org/W1966339894","https://openalex.org/W1968624339","https://openalex.org/W1969821478","https://openalex.org/W1970043986","https://openalex.org/W1978492271","https://openalex.org/W1979043688","https://openalex.org/W1979852216","https://openalex.org/W1980230515","https://openalex.org/W1980810447","https://openalex.org/W1981359573","https://openalex.org/W1982022033","https://openalex.org/W1982205033","https://openalex.org/W1983160604","https://openalex.org/W1985286185","https://openalex.org/W1986234750","https://openalex.org/W1987081597","https://openalex.org/W1988297612","https://openalex.org/W1991866002","https://openalex.org/W2000204411","https://openalex.org/W2004536682","https://openalex.org/W2008030699","https://openalex.org/W2016177057","https://openalex.org/W2017770342","https://openalex.org/W2020578828","https://openalex.org/W2020680746","https://openalex.org/W2023367024","https://openalex.org/W2024751716","https://openalex.org/W2030927418","https://openalex.org/W2031084334","https://openalex.org/W2032494769","https://openalex.org/W2033583601","https://openalex.org/W2035809865","https://openalex.org/W2037883636","https://openalex.org/W2037966393","https://openalex.org/W2038120901","https://openalex.org/W2038757125","https://openalex.org/W2038920846","https://openalex.org/W2039039155","https://openalex.org/W2039751388","https://openalex.org/W2040612034","https://openalex.org/W2041482977","https://openalex.org/W2042626190","https://openalex.org/W2042961694","https://openalex.org/W2044654272","https://openalex.org/W2045733021","https://openalex.org/W2047724064","https://openalex.org/W2049914044","https://openalex.org/W2054245229","https://openalex.org/W2055355527","https://openalex.org/W2056510698","https://openalex.org/W2056879548","https://openalex.org/W2061172918","https://openalex.org/W2064090932","https://openalex.org/W2064140933","https://openalex.org/W2065007096","https://openalex.org/W2065126426","https://openalex.org/W2065696528","https://openalex.org/W2072411272","https://openalex.org/W2073322731","https://openalex.org/W2074661552","https://openalex.org/W2075037119","https://openalex.org/W2075188442","https://openalex.org/W2077631278","https://openalex.org/W2079577310","https://openalex.org/W2084324436","https://openalex.org/W2085879860","https://openalex.org/W2089127919","https://openalex.org/W2090059131","https://openalex.org/W2090851364","https://openalex.org/W2094024512","https://openalex.org/W2095545132","https://openalex.org/W2100555346","https://openalex.org/W2105751954","https://openalex.org/W2107908886","https://openalex.org/W2108335498","https://openalex.org/W2110186212","https://openalex.org/W2111706254","https://openalex.org/W2112267683","https://openalex.org/W2113012066","https://openalex.org/W2114511659","https://openalex.org/W2115110568","https://openalex.org/W2122310533","https://openalex.org/W2122380860","https://openalex.org/W2125494260","https://openalex.org/W2125650861","https://openalex.org/W2126543235","https://openalex.org/W2128545033","https://openalex.org/W2128605125","https://openalex.org/W2130349041","https://openalex.org/W2132670847","https://openalex.org/W2142207476","https://openalex.org/W2145185401","https://openalex.org/W2148353419","https://openalex.org/W2149942972","https://openalex.org/W2150181574","https://openalex.org/W2151017891","https://openalex.org/W2151107265","https://openalex.org/W2151949105","https://openalex.org/W2156279609","https://openalex.org/W2156930945","https://openalex.org/W2159358845","https://openalex.org/W2159604840","https://openalex.org/W2159999899","https://openalex.org/W2160457264","https://openalex.org/W2160591911","https://openalex.org/W2161497340","https://openalex.org/W2161785869","https://openalex.org/W2164706538","https://openalex.org/W2167569919","https://openalex.org/W2167871776","https://openalex.org/W2171783221","https://openalex.org/W2172221620","https://openalex.org/W2316562588","https://openalex.org/W2325038063","https://openalex.org/W2335354937","https://openalex.org/W2470407620","https://openalex.org/W2764433274"],"related_works":["https://openalex.org/W7043185680","https://openalex.org/W6998525647","https://openalex.org/W194884046","https://openalex.org/W7155050950","https://openalex.org/W2969583012","https://openalex.org/W2470262022","https://openalex.org/W2915636862","https://openalex.org/W2018671549","https://openalex.org/W7097980363","https://openalex.org/W2282871950"],"abstract_inverted_index":{"Project":[0],"1:":[1],"Myelination":[2],"plays":[3],"a":[4,26,47,73,114],"key":[5],"role":[6,27,49,115],"in":[7,40,53,67,72,84,92,145,159,184],"both":[8,54,131],"the":[9,29,51,55,68,93,117,207,248],"developing":[10,69,157],"CNS":[11],"and":[12,32,57,90,133,138,167,178,194,198,216,229,234,241],"repair":[13,58],"from":[14],"neurodegenerative":[15],"diseases":[16],"such":[17],"as":[18,119],"multiple":[19,245],"sclerosis":[20],"(MS).":[21],"Previous":[22],"work":[23],"has":[24],"suggested":[25],"for":[28,50,116],"amphoterin-induced":[30],"gene":[31],"open":[33],"reading":[34],"frame":[35],"(AMIGO)":[36],"family":[37],"of":[38,60,123,149,162,165,190,209,225],"proteins":[39],"this":[41],"process.":[42],"Data":[43],"shown":[44],"here":[45],"proposes":[46],"novel":[48],"AMIGOs":[52,118],"developmental":[56],"processes":[59],"myelination.":[61,78,124],"Immunofluorescent":[62],"staining":[63],"showed":[64],"AMIGO":[65,79],"expression":[66,80],"mouse":[70],"brain":[71],"similar,":[74],"progressive":[75],"pattern":[76],"to":[77,175,212],"was":[81,153,186,220],"also":[82],"found":[83],"oligodendrocyte":[85],"precursor":[86],"cells":[87,102,136],"(OPCs),":[88],"oligodendrocytes":[89],"astrocytes":[91],"spinal":[94],"cord":[95],"during":[96],"experimental":[97],"autoimmune":[98],"encephalomyelitis":[99],"(EAE).":[100],"These":[101,110],"are":[103],"either":[104],"myelinating":[105],"or":[106],"have":[107,244],"myelination-regulating":[108],"function.":[109],"combined":[111],"results":[112],"suggest":[113,238],"potential":[120],"positive":[121],"regulators":[122],"\\n":[125,251],"\\nProject":[126],"2:":[127],"Evidence":[128],"suggests":[129],"that":[130,239],"mesenchymal":[132],"hematopoietic":[134],"stem":[135],"(MSCs":[137],"HSCs)":[139],"can":[140],"alter":[141],"an":[142,158],"inflammatory":[143,249],"environment":[144],"vivo":[146],"by":[147,155,188,223],"secretion":[148],"inflammation-modulating":[150],"agents.":[151],"This":[152,182,218,236],"examined":[154],"first":[156],"vitro":[160],"model":[161],"inflammation.":[163],"Addition":[164],"MSC":[166],"HSC":[168],"conditioned":[169],"media":[170,205],"increased":[171],"Kc-activated":[172],"neutrophil":[173],"adhesion":[174,185,208],"TNF-\u03b1-activated":[176],"colon":[177],"renal":[179],"endothelium,":[180],"respectively.":[181],"increase":[183],"enhanced":[187],"pre-stimulation":[189],"SCs":[191,226],"with":[192,202,227],"cytokines":[193,228],"chemokines,":[195,230],"particularly":[196,231],"H2O2":[197],"TNF-\u03b1.":[199],"Similarly,":[200],"treatment":[201,224],"different":[203],"SC-conditioned":[204],"altered":[206],"activated":[210],"neutrophils":[211],"VCAM-1,":[213],"ICAM-1,":[214],"MAdCAM1":[215],"hyaluronan.":[217],"effect":[219],"further":[221],"manipulated":[222],"H2O2,":[232],"TNF-\u03b1":[233],"IFN-\u03b3.":[235],"data":[237],"MSCs":[240],"HSCs":[242],"potentially":[243],"effects":[246],"on":[247],"site":[250]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
