{"id":"https://openalex.org/W1986644699","doi":"https://doi.org/10.1161/01.cir.86.2.431","title":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators.","display_name":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators.","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W1986644699","doi":"https://doi.org/10.1161/01.cir.86.2.431","mag":"1986644699","pmid":"https://pubmed.ncbi.nlm.nih.gov/1638712"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.86.2.431","doi":"https://doi.org/10.1161/01.cir.86.2.431","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.86.2.431","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.86.2.431","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.86.2.431","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051961415","display_name":"Marvin A. Konstam","orcid":"https://orcid.org/0000-0001-6163-8399","observed_orcids":["https://orcid.org/0000-0001-6163-8399"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Konstam","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045343464","display_name":"Michel F. Rousseau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M F Rousseau","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009487552","display_name":"Marvin W. Kronenberg","orcid":"https://orcid.org/0000-0002-8431-5645","observed_orcids":["https://orcid.org/0000-0002-8431-5645","https://orcid.org/0009-0006-6729-5351"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Kronenberg","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080222829","display_name":"James E. Udelson","orcid":"https://orcid.org/0000-0003-2998-910X","observed_orcids":["https://orcid.org/0000-0003-2998-910X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Udelson","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Melin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Melin","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Stewart","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024775260","display_name":"Noreen Dolan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Dolan","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055412425","display_name":"Tonya R. Edens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T R Edens","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698756","display_name":"S.A. Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ahn","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086133945","display_name":"Debra Kinan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Kinan","raw_affiliation_strings":["Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tufts University, New England Medical Center, Boston, MA 02111","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":23.4532,"has_fulltext":true,"cited_by_count":602,"citation_normalized_percentile":{"value":0.99696368,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"86","issue":"2","first_page":"431","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9419999718666077},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/left-ventricular-dilation","display_name":"left ventricular dilatation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.6880000233650208},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.921999990940094},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-pressure","display_name":"left ventricular end-diastolic pressure","score":0.7990000247955322},{"id":"https://openalex.org/keywords/left-ventricular-relaxation","display_name":"left ventricular relaxation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/radionuclide-ventriculography","display_name":"radionuclide ventriculography","score":0.8230000138282776},{"id":"https://openalex.org/keywords/left-heart-catheterization","display_name":"left heart catheterization","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.9749453067779541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.910203218460083},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.8016875982284546},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8000507950782776},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7025995850563049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6866815686225891},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.6337832808494568},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.6034903526306152},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5466232895851135},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5063992738723755},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4923824071884155},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3604741096496582},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25757938623428345},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015637","descriptor_name":"Gated Blood-Pool Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.86.2.431","doi":"https://doi.org/10.1161/01.cir.86.2.431","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.86.2.431","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.86.2.431","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:1638712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1638712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Clinical Trial"},{"id":"mag:3141976621","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.86.2.1638712?keytype2=tf_ipsecsha&ijkey=7ac3ca196b56fc90f2661a2fe446e09436ac2944","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.cir.86.2.431","doi":"https://doi.org/10.1161/01.cir.86.2.431","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.86.2.431","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.86.2.431","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3017674511","display_name":null,"funder_award_id":"N01-HC-55010","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8673411619","display_name":"STUDIES OF LEFT VENTRICULAR DYSFUNCTION","funder_award_id":"n01hc055010-009","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986644699.pdf","grobid_xml":"https://content.openalex.org/works/W1986644699.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1812289286","https://openalex.org/W1965449074","https://openalex.org/W1977173164","https://openalex.org/W1982649663","https://openalex.org/W1996753402","https://openalex.org/W2028273454","https://openalex.org/W2028455468","https://openalex.org/W2034991124","https://openalex.org/W2038983371","https://openalex.org/W2051165221","https://openalex.org/W2055420779","https://openalex.org/W2068849227","https://openalex.org/W2074588774","https://openalex.org/W2079228010","https://openalex.org/W2089125087","https://openalex.org/W2103673693","https://openalex.org/W2110484105","https://openalex.org/W2141751792","https://openalex.org/W2143781750","https://openalex.org/W2159096663","https://openalex.org/W2323862874","https://openalex.org/W2340149484"],"related_works":["https://openalex.org/W7055983923","https://openalex.org/W1981884097","https://openalex.org/W7028042081","https://openalex.org/W7098596626","https://openalex.org/W348840331","https://openalex.org/W4232136292","https://openalex.org/W2078395346","https://openalex.org/W2138702613","https://openalex.org/W7018751296","https://openalex.org/W2396963280"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,312],"patients":[2,54,71,85,206,313],"with":[3,55,86,236,309,314,323],"heart":[4,62,90,101,315],"failure,":[5],"activation":[6],"of":[7,37,70,77,79,240,245,276,293,341],"the":[8,32,38,74,172,198,251,286,305],"renin-angiotensin":[9],"system":[10],"is":[11],"common":[12],"and":[13,27,50,60,96,104,137,161,175,187,296,317,329,344,349],"has":[14],"been":[15],"postulated":[16],"to":[17,88,107,156,166,182,192,211,265,299,304],"provide":[18],"a":[19,221,274,339],"stimulus":[20],"for":[21],"further":[22],"left":[23,100],"ventricular":[24],"(LV)":[25],"structural":[26],"functional":[28],"derangement.":[29],"We":[30,67],"tested":[31],"hypothesis":[33],"that":[34],"chronic":[35,320],"administration":[36],"angiotensin":[39],"converting":[40],"enzyme":[41],"(ACE)":[42],"inhibitor":[43],"enalapril":[44,108,199,205,324],"prevents":[45,325],"or":[46,111],"reverses":[47],"LV":[48,122,226,246,282,327],"dilatation":[49,328],"systolic":[51,330],"dysfunction":[52,331],"among":[53],"depressed":[56],"ejection":[57],"fraction":[58],"(EF)":[59],"symptomatic":[61],"failure.":[63],"METHODS":[64],"AND":[65],"RESULTS:":[66],"examined":[68],"subsets":[69],"enrolled":[72],"in":[73,121,148,171,177,197,204,225,250,281,285,347],"Treatment":[75],"Trial":[76],"Studies":[78],"Left":[80],"Ventricular":[81],"Dysfunction":[82],"(SOLVD).":[83],"Fifty-six":[84],"mild":[87],"moderate":[89],"failure":[91,316],"underwent":[92,98],"serial":[93,99],"radionuclide":[94,271],"ventriculograms,":[95],"16":[97],"catheterizations,":[102],"before":[103],"after":[105,291],"randomization":[106],"(2.5-20":[109],"mg/day)":[110],"placebo.":[112,310],"At":[113],"1":[114,230],"year,":[115],"there":[116],"were":[117],"significant":[118,222],"treatment":[119,223],"differences":[120],"end-diastolic":[123,227],"volume":[124,131],"(EDV;":[125],"p":[126,133],"less":[127,134,140,216,233,255],"than":[128,135,141,217,234,256],"0.01),":[129],"end-systolic":[130],"(ESV;":[132],"0.005),":[136],"EF":[138],"(p":[139,215,232,254],"0.05).":[142],"These":[143,334],"effects":[144,335],"resulted":[145],"from":[146,207,261,338],"increases":[147,280],"EDV":[149,178,295],"(mean":[150],"+/-":[151,154,158,164,168,180,184,190,194,209,213,263,267],"SD,":[152],"136":[153],"27":[155],"151":[157],"38":[159],"ml/m2)":[160,170,186,196],"ESV":[162,188,297],"(103":[163],"24":[165,169],"116":[167],"placebo":[173,252,287],"group":[174,253],"decreases":[176],"(140":[179],"44":[181],"127":[183],"37":[185,195],"(106":[189],"42":[191],"93":[193],"group.":[200,288],"Mean":[201],"LVEF":[202],"increased":[203,298],"0.25":[208],"0.07":[210],"0.29":[212],"0.08":[214],"0.01).":[218],"There":[219],"was":[220],"difference":[224],"pressure":[228],"at":[229],"year":[231],"0.05),":[235],"changes":[237],"paralleling":[238],"those":[239],"EDV.":[241],"The":[242],"time":[243],"constant":[244],"relaxation":[247],"changed":[248],"only":[249,284],"0.01":[257],"versus":[258],"enalapril),":[259],"increasing":[260],"59.2":[262],"8.0":[264],"67.8":[266],"7.2":[268],"msec.":[269],"Serial":[270],"studies":[272],"over":[273],"period":[275],"33":[277],"months":[278],"showed":[279],"volumes":[283],"Two":[289],"weeks":[290],"withdrawal":[292],"enalapril,":[294],"baseline":[300],"levels":[301,307],"but":[302],"not":[303],"higher":[306],"observed":[308],"CONCLUSIONS:":[311],"reduced":[318],"LVEF,":[319],"ACE":[321],"inhibition":[322],"progressive":[326],"(increased":[332],"ESV).":[333],"probably":[336],"result":[337],"combination":[340],"altered":[342],"remodeling":[343],"sustained":[345],"reduction":[346],"preload":[348],"afterload.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}