{"id":"https://openalex.org/W1986642686","doi":"https://doi.org/10.1021/jm701595q","title":"Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors","display_name":"Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors","publication_year":2008,"publication_date":"2008-03-19","ids":{"openalex":"https://openalex.org/W1986642686","doi":"https://doi.org/10.1021/jm701595q","mag":"1986642686","pmid":"https://pubmed.ncbi.nlm.nih.gov/18348515"},"language":"en","primary_location":{"id":"doi:10.1021/jm701595q","doi":"https://doi.org/10.1021/jm701595q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm701595q","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012839091","display_name":"Antonello Mai","orcid":"https://orcid.org/0000-0001-9176-2382","observed_orcids":["https://orcid.org/0000-0001-9176-2382"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":true,"raw_author_name":"Antonello Mai","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023647372","display_name":"Donghang Cheng","orcid":"https://orcid.org/0000-0001-7356-450X","observed_orcids":["https://orcid.org/0000-0001-7356-450X"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Donghang Cheng","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001008905","display_name":"Mark T. Bedford","orcid":"https://orcid.org/0000-0002-8899-1050","observed_orcids":["https://orcid.org/0000-0002-8899-1050"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":true,"raw_author_name":"Mark T. Bedford","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084101516","display_name":"S\u00e9rgio Valente","orcid":"https://orcid.org/0000-0002-2241-607X","observed_orcids":["https://orcid.org/0000-0002-2241-607X"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Sergio Valente","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023140151","display_name":"Angela Nebbioso","orcid":"https://orcid.org/0000-0001-5374-3527","observed_orcids":["https://orcid.org/0000-0001-5374-3527"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Angela Nebbioso","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","Second Univ. of Naples"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Second Univ. of Naples","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrea Perrone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Andrea Perrone","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060401985","display_name":"Gerald Brosch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Gerald Brosch","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017825556","display_name":"Gianluca Sbardella","orcid":"https://orcid.org/0000-0003-0748-1145","observed_orcids":["https://orcid.org/0000-0003-0748-1145"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":true,"raw_author_name":"Gianluca Sbardella","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055517422","display_name":"Floriana De Bellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Floriana De Bellis","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","IGBCM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]},{"raw_affiliation_string":"IGBCM","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050044586","display_name":"Marco Miceli","orcid":"https://orcid.org/0000-0001-5806-1488","observed_orcids":["https://orcid.org/0000-0001-5806-1488"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Marco Miceli","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","Second Univ. of Naples"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Second Univ. of Naples","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039682482","display_name":"Lucia Altucci","orcid":"https://orcid.org/0000-0002-7312-5387","observed_orcids":["https://orcid.org/0000-0002-7312-5387"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["AT","IT"],"is_corresponding":true,"raw_author_name":"Lucia Altucci","raw_affiliation_strings":["Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, P.le A. Moro 5, 00185 Roma, Italy, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, Dipartimento di Patologia Generale, Seconda Universit\u00e0 degli Studi di Napoli, vico L. De Crecchio 7, 80138 Napoli, Italy, Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Preglstrasse 3, 6020 Innsbruck,","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001008905","https://openalex.org/A5012839091","https://openalex.org/A5017825556","https://openalex.org/A5039682482"],"corresponding_institution_ids":["https://openalex.org/I143397708","https://openalex.org/I4210153523","https://openalex.org/I861853513"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.2948,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.97095206,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"51","issue":"7","first_page":"2279","last_page":"2290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-arginine-methyltransferase","display_name":"protein arginine methyltransferase","score":0.8009999990463257},{"id":"https://openalex.org/keywords/histone-lysine-methyltransferase","display_name":"histone lysine methyltransferase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/prmt1","display_name":"PRMT1","score":0.7129999995231628},{"id":"https://openalex.org/keywords/carm1","display_name":"CARM1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/set7","display_name":"SET7","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/cytodifferentiation","display_name":"cytodifferentiation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sirtinol","display_name":"sirtinol","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8076186180114746},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6686772108078003},{"id":"https://openalex.org/C2778001298","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone acetyltransferase","level":4,"score":0.6253538727760315},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5088613033294678},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4999196529388428},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.48812851309776306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4432789087295532},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.421028196811676},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.3862037658691406},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37780070304870605},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32974570989608765},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1112293004989624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09584340453147888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099186","descriptor_name":"Histone Deacetylase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/jm701595q","doi":"https://doi.org/10.1021/jm701595q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm701595q","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:18348515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18348515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unicampania.it:11591/189446","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/189446","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/13425","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-41849146748&partnerID=65&md5=6b25bc95950fa5d7b8ff79d70ca9a9c3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2536026507","display_name":"Small Molecule Regulators of Arginine Methyltransferases","funder_award_id":"R01CA114116","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W175416543","https://openalex.org/W1551972473","https://openalex.org/W1926638730","https://openalex.org/W1964575217","https://openalex.org/W1965538235","https://openalex.org/W1966422320","https://openalex.org/W1967018540","https://openalex.org/W1970475284","https://openalex.org/W1970716813","https://openalex.org/W1970772467","https://openalex.org/W1975602880","https://openalex.org/W1975690301","https://openalex.org/W1977112537","https://openalex.org/W1978683242","https://openalex.org/W1981433258","https://openalex.org/W1985944726","https://openalex.org/W1988492454","https://openalex.org/W1988829982","https://openalex.org/W1990861922","https://openalex.org/W1990931780","https://openalex.org/W1992116796","https://openalex.org/W2004172747","https://openalex.org/W2009121506","https://openalex.org/W2009204250","https://openalex.org/W2010426046","https://openalex.org/W2015660958","https://openalex.org/W2018600278","https://openalex.org/W2020431264","https://openalex.org/W2021931700","https://openalex.org/W2026106173","https://openalex.org/W2027704006","https://openalex.org/W2028733293","https://openalex.org/W2032649908","https://openalex.org/W2035436935","https://openalex.org/W2037691690","https://openalex.org/W2038275607","https://openalex.org/W2041269990","https://openalex.org/W2044000724","https://openalex.org/W2050159754","https://openalex.org/W2052664638","https://openalex.org/W2057602929","https://openalex.org/W2058249625","https://openalex.org/W2061050600","https://openalex.org/W2062768506","https://openalex.org/W2065335945","https://openalex.org/W2066544271","https://openalex.org/W2070234396","https://openalex.org/W2071579231","https://openalex.org/W2073863100","https://openalex.org/W2078364998","https://openalex.org/W2079499545","https://openalex.org/W2080057665","https://openalex.org/W2082170965","https://openalex.org/W2083611453","https://openalex.org/W2086882324","https://openalex.org/W2086990980","https://openalex.org/W2088381487","https://openalex.org/W2091632400","https://openalex.org/W2093087462","https://openalex.org/W2095054695","https://openalex.org/W2098536205","https://openalex.org/W2099803844","https://openalex.org/W2100115661","https://openalex.org/W2100283599","https://openalex.org/W2104600818","https://openalex.org/W2105259065","https://openalex.org/W2107866135","https://openalex.org/W2111862114","https://openalex.org/W2120207658","https://openalex.org/W2125121177","https://openalex.org/W2126351102","https://openalex.org/W2144600435","https://openalex.org/W2144806790","https://openalex.org/W2145955453","https://openalex.org/W2152518502","https://openalex.org/W2155725346","https://openalex.org/W2157830796","https://openalex.org/W2160824495","https://openalex.org/W2163583950","https://openalex.org/W2165938086","https://openalex.org/W2167789852","https://openalex.org/W2168455351","https://openalex.org/W2170964470","https://openalex.org/W2172496848","https://openalex.org/W2346257945","https://openalex.org/W4211231408"],"related_works":["https://openalex.org/W2038275607","https://openalex.org/W2930598019","https://openalex.org/W1977366067","https://openalex.org/W2766602108","https://openalex.org/W4383484924","https://openalex.org/W2906539375","https://openalex.org/W7097157813","https://openalex.org/W7099759483","https://openalex.org/W3016136962","https://openalex.org/W2895800080"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,26,33,51,95],"new":[3],"compounds":[4,45,97],"bearing":[5],"two":[6],"ortho-bromo-":[7],"and":[8,37,42,55,57,65,77,106,115,149,161,171],"ortho,":[9],"ortho-dibromophenol":[10],"moieties":[11],"linked":[12],"through":[13],"a":[14,29,49,69,177],"saturated/unsaturated,":[15],"linear/(poly)cyclic":[16],"spacer":[17],"(compounds":[18],"1-":[19],"9)":[20],"were":[21,46,72,108,173],"prepared":[22],"as":[23,68,122],"simplified":[24],"analogues":[25],"AMI-5":[27],"(eosin),":[28],"recently":[30],"reported":[31],"inhibitor":[32],"both":[34],"protein":[35],"arginine":[36],"histone":[38,64],"lysine":[39],"methyltransferases":[40],"(PRMTs":[41],"HKMTs).":[43],"Such":[44],"tested":[47,96,131],"against":[48,58,75],"panel":[50],"PRMTs":[52],"(RmtA,":[53],"PRMT1,":[54],"CARM1)":[56],"human":[59,134],"SET7":[60],"(a":[61],"HKMT),":[62],"using":[63],"nonhistone":[66],"proteins":[67],"substrate.":[70],"They":[71],"also":[73],"screened":[74],"HAT":[76,86],"SIRTs,":[78],"because":[79],"they":[80],"are":[81],"structurally":[82],"related":[83],"to":[84,110],"some":[85,94],"and/or":[87,153],"SIRT":[88],"modulators.":[89],"From":[90],"the":[91,133,139,166],"inhibitory":[92],"data,":[93],"(":[98,147,151,159,163],"1b,":[99],"1c,":[100],"4b,":[101],"4f,":[102],"4j,":[103],"4l,":[104],"7b,":[105],"7f)":[107],"able":[109],"inhibit":[111],"PRMTs,":[112],"HKMT,":[113],"HAT,":[114],"SIRTs":[116],"with":[117],"similar":[118],"potency,":[119],"thus":[120],"behaving":[121],"multiple":[123],"ligands":[124],"for":[125],"these":[126],"epigenetic":[127],"targets":[128],"(epi-MLs).":[129],"When":[130],"on":[132],"leukemia":[135],"U937":[136],"cell":[137],"line,":[138],"epi-MLs":[140],"induced":[141],"high":[142],"apoptosis":[143],"levels":[144],"[i.e.,":[145,157],"40.7%":[146],"4l)":[148],"42.6%":[150],"7b)]":[152],"massive,":[154],"dose-dependent":[155],"cytodifferentiation":[156],"95.2%":[158],"1c)":[160],"96.1%":[162],"4j)],":[164],"whereas":[165],"single-target":[167],"inhibitors":[168],"eosin,":[169],"curcumin,":[170],"sirtinol":[172],"ineffective":[174],"or":[175],"showed":[176],"weak":[178],"effect.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}