{"id":"https://openalex.org/W1986573391","doi":"https://doi.org/10.1517/14656566.2011.598856","title":"Pharmacologic management of postoperative nausea and vomiting","display_name":"Pharmacologic management of postoperative nausea and vomiting","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W1986573391","doi":"https://doi.org/10.1517/14656566.2011.598856","mag":"1986573391","pmid":"https://pubmed.ncbi.nlm.nih.gov/21756206"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.2011.598856","doi":"https://doi.org/10.1517/14656566.2011.598856","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.2011.598856","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065925659","display_name":"Katherine Elaine Fero","orcid":"https://orcid.org/0000-0002-2155-960X","observed_orcids":["https://orcid.org/0000-0002-2155-960X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E Fero","raw_affiliation_strings":["University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074853209","display_name":"Leena Jalota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799409606","display_name":"Reading Hospital","ror":"https://ror.org/04kk13p96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799409606"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leena Jalota","raw_affiliation_strings":["Internal Medicine Resident, Reading Hospital & Medical Center, Reading, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Resident, Reading Hospital & Medical Center, Reading, PA, USA","institution_ids":["https://openalex.org/I2799409606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027788334","display_name":"Cyrill Hornu\u00df","orcid":"https://orcid.org/0009-0004-9838-5646","observed_orcids":["https://orcid.org/0009-0004-9838-5646"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cyrill Hornuss","raw_affiliation_strings":["University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015537537","display_name":"Christian C. Apfel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian C Apfel","raw_affiliation_strings":["University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA +1 415 885 7842; +1 415 885 7770; apfelc@anesthesia.ucsf.edu or apfel@ponv.org","+1 415 885 7770","University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA +1 415 885 7842"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA +1 415 885 7842; +1 415 885 7770; apfelc@anesthesia.ucsf.edu or apfel@ponv.org","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"+1 415 885 7770","institution_ids":[]},{"raw_affiliation_string":"University of California, UCSF Medical Center, Department of Anesthesia and Perioperative Care, Mount Zion Campus, 1600 Divisadero, C-447, San Francisco, CA 94115, USA +1 415 885 7842","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0337,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.66470357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"15","first_page":"2283","last_page":"2296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":1.0},{"id":"https://openalex.org/keywords/antiemetic-prophylaxis","display_name":"antiemetic prophylaxis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antiemetic-therapy","display_name":"antiemetic therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ponv-risk-factors","display_name":"PONV risk factors","score":0.925000011920929},{"id":"https://openalex.org/keywords/opioid-induced-nausea","display_name":"opioid-induced nausea","score":0.5929999947547913},{"id":"https://openalex.org/keywords/inhalational-anesthetics","display_name":"inhalational anesthetics","score":0.9409999847412109},{"id":"https://openalex.org/keywords/total-intravenous-anesthesia","display_name":"total intravenous anesthesia","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9480657577514648},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.8257415294647217},{"id":"https://openalex.org/C2777297131","wikidata":"https://www.wikidata.org/wiki/Q1658731","display_name":"Postoperative nausea and vomiting","level":3,"score":0.8188856840133667},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6719050407409668},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6622390747070312},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5796216130256653},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4489806592464447},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4469979703426361},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.4245571494102478},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23300224542617798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0689898431301117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020250","descriptor_name":"Postoperative Nausea and Vomiting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020250","descriptor_name":"Postoperative Nausea and Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020250","descriptor_name":"Postoperative Nausea and Vomiting","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.2011.598856","doi":"https://doi.org/10.1517/14656566.2011.598856","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.2011.598856","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:21756206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21756206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W1384845","https://openalex.org/W36820478","https://openalex.org/W109546736","https://openalex.org/W180391124","https://openalex.org/W187725619","https://openalex.org/W1506721390","https://openalex.org/W1532331089","https://openalex.org/W1554827207","https://openalex.org/W1851561674","https://openalex.org/W1965338729","https://openalex.org/W1969011462","https://openalex.org/W1969171934","https://openalex.org/W1971019459","https://openalex.org/W1974232104","https://openalex.org/W1974445114","https://openalex.org/W1974724354","https://openalex.org/W1975557702","https://openalex.org/W1976532277","https://openalex.org/W1977121588","https://openalex.org/W1977674360","https://openalex.org/W1979174731","https://openalex.org/W1980533538","https://openalex.org/W1981274428","https://openalex.org/W1981600033","https://openalex.org/W1987394352","https://openalex.org/W1987477051","https://openalex.org/W1989411527","https://openalex.org/W1990747711","https://openalex.org/W1991053107","https://openalex.org/W1992594561","https://openalex.org/W1993457930","https://openalex.org/W1996514636","https://openalex.org/W1999179893","https://openalex.org/W2000440206","https://openalex.org/W2000593094","https://openalex.org/W2003970587","https://openalex.org/W2008938165","https://openalex.org/W2013321018","https://openalex.org/W2013976105","https://openalex.org/W2014001501","https://openalex.org/W2014871043","https://openalex.org/W2017659594","https://openalex.org/W2017673034","https://openalex.org/W2020856215","https://openalex.org/W2021631141","https://openalex.org/W2026539804","https://openalex.org/W2027206415","https://openalex.org/W2031786331","https://openalex.org/W2033504891","https://openalex.org/W2034100536","https://openalex.org/W2035404074","https://openalex.org/W2037016226","https://openalex.org/W2039621084","https://openalex.org/W2040650990","https://openalex.org/W2043437749","https://openalex.org/W2044847214","https://openalex.org/W2048034228","https://openalex.org/W2054655234","https://openalex.org/W2055998709","https://openalex.org/W2057450456","https://openalex.org/W2059136132","https://openalex.org/W2059351513","https://openalex.org/W2064095633","https://openalex.org/W2069671955","https://openalex.org/W2076033624","https://openalex.org/W2076484550","https://openalex.org/W2076585267","https://openalex.org/W2077054055","https://openalex.org/W2080017976","https://openalex.org/W2080551366","https://openalex.org/W2080816570","https://openalex.org/W2084371230","https://openalex.org/W2084564619","https://openalex.org/W2084899864","https://openalex.org/W2086571500","https://openalex.org/W2087679152","https://openalex.org/W2087863668","https://openalex.org/W2092070157","https://openalex.org/W2094291439","https://openalex.org/W2095153551","https://openalex.org/W2095368589","https://openalex.org/W2096691031","https://openalex.org/W2108194072","https://openalex.org/W2109177499","https://openalex.org/W2109299163","https://openalex.org/W2112257961","https://openalex.org/W2112415706","https://openalex.org/W2115252962","https://openalex.org/W2116505170","https://openalex.org/W2118259237","https://openalex.org/W2122567007","https://openalex.org/W2127736808","https://openalex.org/W2127992301","https://openalex.org/W2131400892","https://openalex.org/W2133551730","https://openalex.org/W2133760117","https://openalex.org/W2133961060","https://openalex.org/W2136091942","https://openalex.org/W2136374429","https://openalex.org/W2136444635","https://openalex.org/W2137297986","https://openalex.org/W2137870195","https://openalex.org/W2138647766","https://openalex.org/W2153494490","https://openalex.org/W2154735290","https://openalex.org/W2155726820","https://openalex.org/W2161013317","https://openalex.org/W2162845029","https://openalex.org/W2164832682","https://openalex.org/W2164907650","https://openalex.org/W2165137445","https://openalex.org/W2165623624","https://openalex.org/W2165827578","https://openalex.org/W2166860356","https://openalex.org/W2169854009","https://openalex.org/W2170860918","https://openalex.org/W2197995441","https://openalex.org/W2218699541","https://openalex.org/W2341319633","https://openalex.org/W2404945464","https://openalex.org/W2406226208","https://openalex.org/W2416989406","https://openalex.org/W2418422478","https://openalex.org/W2570513141","https://openalex.org/W2617002364","https://openalex.org/W2911786565","https://openalex.org/W4210592966","https://openalex.org/W4239202739","https://openalex.org/W4239570240","https://openalex.org/W4416702741"],"related_works":["https://openalex.org/W7214962929","https://openalex.org/W7212252815","https://openalex.org/W3191148252","https://openalex.org/W7126221679","https://openalex.org/W139673228","https://openalex.org/W4407973599","https://openalex.org/W2070772752","https://openalex.org/W297661399","https://openalex.org/W2409819266","https://openalex.org/W2086194627"],"abstract_inverted_index":{"INTRODUCTION:":[0],"As":[1],"advances":[2],"in":[3],"the":[4,58,108,124,142,149,175,181,198],"safety":[5],"and":[6,10,21,35,60,64,83,99,147],"efficacy":[7,154],"of":[8,32,57,62,65,144,155,177,197,207],"surgery":[9],"anesthesia":[11,95,121,131,138],"have":[12,24,41,164],"been":[13,42],"made,":[14],"other":[15],"complications":[16],"such":[17,117],"as":[18,37,39,112,114,139,160,162],"postoperative":[19],"nausea":[20],"vomiting":[22],"(PONV)":[23],"become":[25],"more":[26],"apparent.":[27],"PONV":[28,92],"occurs":[29],"after":[30],"30%":[31],"all":[33],"surgeries,":[34],"incidences":[36],"high":[38,47,113],"80%":[40],"reported":[43],"among":[44],"patients":[45],"at":[46],"risk.":[48],"AREAS":[49],"COVERED:":[50],"This":[51],"review":[52],"provides":[53],"a":[54,188,204],"brief":[55],"overview":[56],"etiology":[59],"mechanisms":[61],"emesis":[63],"known":[66],"risk":[67,109,150,185,200],"factors":[68],"for":[69,91,151,168],"PONV.":[70,152],"It":[71],"also":[72],"covers":[73],"pharmacologic":[74],"therapies,":[75],"appropriate":[76],"management":[77],"strategies,":[78,80],"prophylactic":[79],"multimodal":[81],"therapy":[82],"rescue":[84],"treatment.":[85],"EXPERT":[86],"OPINION:":[87],"The":[88],"main":[89],"triggers":[90],"are":[93],"general":[94,130],"with":[96],"inhalational":[97,145],"anesthetics":[98,146],"opioids.":[100],"When":[101],"given":[102],"to":[103,173,180],"susceptible":[104],"patients,":[105,118],"e.g.,":[106],"females,":[107],"may":[110],"be":[111,123],"80%.":[115],"In":[116],"opioid-free":[119],"regional":[120],"would":[122],"most":[125],"logical":[126],"approach.":[127],"However,":[128],"if":[129],"is":[132,158],"needed,":[133],"we":[134,171,202],"prefer":[135,172],"total":[136],"intravenous":[137],"it":[140],"eliminates":[141],"use":[143,176],"reduces":[148],"Importantly,":[153],"antiemetic":[156,208],"interventions":[157,163],"independent":[159],"long":[161],"different":[165],"mechanisms.":[166],"Thus,":[167],"practical":[169],"purposes,":[170],"titrate":[174],"antiemetics":[178],"according":[179],"validated":[182],"Apfel":[183],"simplified":[184],"score.":[186],"If":[187],"patient":[189],"has":[190],"0,":[191],"1,":[192],"2,":[193],"3":[194],"or":[195],"4":[196],"four":[199],"factors,":[201],"apply":[203],"similar":[205],"number":[206],"strategies.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
