{"id":"https://openalex.org/W1986563371","doi":"https://doi.org/10.1515/bc.2003.048","title":"Induction of Apoptosis in Vascular Cells by Plasminogen Activator Inhibitor-1 and High Molecular Weight Kininogen Correlates with Their Anti-Adhesive Properties","display_name":"Induction of Apoptosis in Vascular Cells by Plasminogen Activator Inhibitor-1 and High Molecular Weight Kininogen Correlates with Their Anti-Adhesive Properties","publication_year":2003,"publication_date":"2003-01-14","ids":{"openalex":"https://openalex.org/W1986563371","doi":"https://doi.org/10.1515/bc.2003.048","mag":"1986563371","pmid":"https://pubmed.ncbi.nlm.nih.gov/12715893"},"language":"en","primary_location":{"id":"doi:10.1515/bc.2003.048","doi":"https://doi.org/10.1515/bc.2003.048","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bc.2003.048","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004147537","display_name":"Nadia Al\u2010Fakhri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Al-Fakhri","raw_affiliation_strings":["Institute of Clinical Chemistry and Pathobiochemistry, Justus Liebig University, Gaffkystrasse 11, D-35392 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Pathobiochemistry, Justus Liebig University, Gaffkystrasse 11, D-35392 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086672334","display_name":"Triantafyllos Chavakis","orcid":"https://orcid.org/0000-0002-1869-5141","observed_orcids":["https://orcid.org/0000-0002-1869-5141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Chavakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052443095","display_name":"Thomas Schmidt-W\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Schmidt-W\u00f6ll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026270755","display_name":"Bei Huang","orcid":"https://orcid.org/0000-0001-9152-1255","observed_orcids":["https://orcid.org/0000-0001-9152-1255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109139507","display_name":"Sanjay Mammen Cherian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.M. Cherian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075043020","display_name":"Yuri Veniaminovich Bobryshev","orcid":"https://orcid.org/0000-0002-3745-321X","observed_orcids":["https://orcid.org/0000-0002-3745-321X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y.V. Bobryshev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110936903","display_name":"Reginald S. A. Lord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.S.A. Lord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108424860","display_name":"Norbert R. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Katz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105839599","display_name":"Klaus T. Preissner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.T. Preissner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":3.4681,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.92454312,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"384","issue":"3","first_page":"423","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.16019999980926514,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/adhesion-prevention","display_name":"adhesion prevention","score":0.8270000219345093},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9089999794960022},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.6169999837875366},{"id":"https://openalex.org/keywords/foam-cells","display_name":"foam cells","score":0.6480000019073486},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neointima","display_name":"neointima","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.8979184627532959},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.6831119656562805},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6274049282073975},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6015793681144714},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5446649193763733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5412333607673645},{"id":"https://openalex.org/C2777339539","wikidata":"https://www.wikidata.org/wiki/Q6993039","display_name":"Neointima","level":4,"score":0.5023572444915771},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4772465229034424},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.4770576059818268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.465293288230896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4178367257118225},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.35634320974349976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3515141010284424},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27752387523651123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17510581016540527},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.1721825897693634},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15960291028022766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10576143860816956},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10541215538978577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08664169907569885},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.0},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.0},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1515/bc.2003.048","doi":"https://doi.org/10.1515/bc.2003.048","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bc.2003.048","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12715893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12715893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:43651","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=43651","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biol. Chem. 384, 423-435 (2003)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W93244428","https://openalex.org/W143880323","https://openalex.org/W158400757","https://openalex.org/W1482082412","https://openalex.org/W1493873711","https://openalex.org/W1498287490","https://openalex.org/W1605543344","https://openalex.org/W1667478348","https://openalex.org/W1670322156","https://openalex.org/W1926488772","https://openalex.org/W1950681626","https://openalex.org/W1966227795","https://openalex.org/W1974105857","https://openalex.org/W1977093166","https://openalex.org/W1988383409","https://openalex.org/W1994082970","https://openalex.org/W2000464138","https://openalex.org/W2008921324","https://openalex.org/W2012408120","https://openalex.org/W2015273569","https://openalex.org/W2021096466","https://openalex.org/W2032518807","https://openalex.org/W2037470923","https://openalex.org/W2045932944","https://openalex.org/W2049404258","https://openalex.org/W2051092663","https://openalex.org/W2052853635","https://openalex.org/W2052910631","https://openalex.org/W2060164605","https://openalex.org/W2062266880","https://openalex.org/W2064564343","https://openalex.org/W2064713347","https://openalex.org/W2065136678","https://openalex.org/W2068710706","https://openalex.org/W2070627144","https://openalex.org/W2082116758","https://openalex.org/W2084330742","https://openalex.org/W2088237907","https://openalex.org/W2115993724","https://openalex.org/W2139847529","https://openalex.org/W2142792362","https://openalex.org/W2147274452","https://openalex.org/W2163963420","https://openalex.org/W2166291746","https://openalex.org/W2171231906","https://openalex.org/W2276184075","https://openalex.org/W2325707043","https://openalex.org/W2398618431","https://openalex.org/W2412055773","https://openalex.org/W2418339090","https://openalex.org/W2474554743"],"related_works":["https://openalex.org/W2122138921","https://openalex.org/W2136243575","https://openalex.org/W1967532342","https://openalex.org/W2075299923","https://openalex.org/W1994234329","https://openalex.org/W2171231906","https://openalex.org/W2039941636","https://openalex.org/W1973635961","https://openalex.org/W2079210929","https://openalex.org/W1989022267"],"abstract_inverted_index":{"Plasminogen":[0],"activator":[1],"inhibitor-1":[2],"(PAI-1)":[3],"and":[4,49,76,100,108,138,169,200],"two-chain":[5],"high":[6],"molecular":[7],"weight":[8],"kininogen":[9],"(HKa)":[10],"exert":[11],"anti-adhesive":[12,25,96,198],"properties":[13],"in":[14,29,41,84,123,175,192,207],"vitronectin-dependent":[15,164],"cell":[16,116,152,165],"adhesion.":[17],"Here,":[18],"the":[19,95,142,180,195],"hypothesis":[20],"was":[21,77,154],"tested":[22],"that":[23,83,161],"these":[24,103],"components":[26,140,191],"promote":[27],"apoptosis":[28,42,91,122,173,186,201],"vascular":[30,50,176],"cells.":[31,104,127],"PAI-1":[32,99,107,168],"or":[33,115,125],"HKa":[34,101,109,170],"induced":[35,86],"a":[36],"2-":[37],"to":[38,56,65,79],"3-fold":[39],"increase":[40],"of":[43,90,98,134,139,141,163,185,197],"human":[44],"umbilical-vein":[45],"endothelial":[46],"cells":[47,53,149,177],"(HUVEC)":[48],"smooth":[51],"muscle":[52],"(VSMC)":[54],"adherent":[55],"vitronectin,":[57,135],"as":[58,206],"determined":[59],"by":[60,156],"annexin":[61],"V-FACS":[62],"assay,":[63],"similar":[64],"alphav-integrin":[66],"inhibitor":[67],"cyclo-(Arg-Gly-Asp-D-Phe-Val)-peptide":[68],"(cRGDfV).":[69],"Apoptosis":[70],"occurred":[71],"after":[72],"12":[73],"h":[74],"incubation":[75],"attributable":[78],"caspase":[80,181],"3":[81,182],"activation":[82,189],"turn":[85],"DNA":[87],"fragmentation.":[88],"Induction":[89],"strongly":[92],"correlated":[93],"with":[94,147,172,187],"effect":[97],"on":[102],"In":[105,128],"contrast,":[106],"did":[110,119],"not":[111,120],"affect":[112],"fibronectin-dependent":[113],"adhesion":[114,166],"survival.":[117],"uPA":[118],"influence":[121],"vitronectin-":[124],"fibronectin-adherent":[126],"atherosclerotic":[129],"vessel":[130],"sections,":[131],"congruent":[132],"distribution":[133],"PAI-1,":[136],"HK,":[137],"urokinase":[143],"plasminogen":[144,188],"activator/receptor":[145],"system":[146,190],"apoptotic":[148],"lining":[150],"foam":[151],"lesions":[153],"demonstrated":[155],"immunostaining.":[157],"These":[158],"results":[159],"indicate":[160],"inhibition":[162],"through":[167,179],"correlates":[171],"induction":[174],"mediated":[178],"pathway.":[183],"Co-distribution":[184],"atherosclerosis":[193],"exemplifies":[194],"significance":[196],"mechanisms":[199],"for":[202],"tissue":[203],"remodeling,":[204],"such":[205],"neointima":[208],"development.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
