{"id":"https://openalex.org/W1986558639","doi":"https://doi.org/10.1097/00003246-199606000-00008","title":"Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat","display_name":"Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1986558639","doi":"https://doi.org/10.1097/00003246-199606000-00008","mag":"1986558639","pmid":"https://pubmed.ncbi.nlm.nih.gov/8681592"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-199606000-00008","doi":"https://doi.org/10.1097/00003246-199606000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199606000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007936401","display_name":"David Y. Moromisato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Y. Moromisato","raw_affiliation_strings":["Division of Respiratory and Critical Care, Harbor-UCLA Medical Center, Torrance, CA 90509, USA","David Y. Moromisato, MD, Division of Respiratory and Critical Care, Bldg. N4, Harbor-UCLA Medical Center, Torrance, CA 90509","the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory and Critical Care, Harbor-UCLA Medical Center, Torrance, CA 90509, USA","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"David Y. Moromisato, MD, Division of Respiratory and Critical Care, Bldg. N4, Harbor-UCLA Medical Center, Torrance, CA 90509","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074028296","display_name":"Mark Y. Moromisato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Y. Moromisato","raw_affiliation_strings":["the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024180642","display_name":"Stefania Zanconato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefania Zanconato","raw_affiliation_strings":["the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009899871","display_name":"Charles T. Roberts","orcid":"https://orcid.org/0000-0003-1756-5772","observed_orcids":["https://orcid.org/0000-0003-1756-5772"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jr Roberts","raw_affiliation_strings":["the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109195692","display_name":"Jo Anne Brasel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo Anne Brasel","raw_affiliation_strings":["the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024191718","display_name":"Dan Michael Cooper","orcid":"https://orcid.org/0000-0003-4022-0043","observed_orcids":["https://orcid.org/0000-0003-4022-0043"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan M. Cooper","raw_affiliation_strings":["the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Respiratory and Critical Care, and Endocrinology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (Drs. D. Moromisato, Zanconato, Brasel, and Cooper, and Mr. M. Morosimato), and the Division of Pediatric Endocrinology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR (Dr. Roberts)","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9682,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.71761409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"6","first_page":"919","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.972000002861023},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9739999771118164},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.847000002861023},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.6299999952316284},{"id":"https://openalex.org/keywords/organ-growth","display_name":"organ growth","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.6819999814033508},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9909999966621399},{"id":"https://openalex.org/keywords/physical-growth","display_name":"physical growth","score":0.8489999771118164},{"id":"https://openalex.org/keywords/igf-i-mrna-expression","display_name":"IGF-I mRNA expression","score":0.7990000247955322},{"id":"https://openalex.org/keywords/igf-i-receptor-binding","display_name":"IGF-I receptor binding","score":0.7860000133514404},{"id":"https://openalex.org/keywords/organ-specific-gene-expression","display_name":"organ-specific gene expression","score":0.6639999747276306},{"id":"https://openalex.org/keywords/fetal-hypoxia","display_name":"fetal hypoxia","score":0.4519999921321869},{"id":"https://openalex.org/keywords/growth-restriction","display_name":"growth restriction","score":0.335999995470047},{"id":"https://openalex.org/keywords/insulin-binding","display_name":"insulin binding","score":0.5239999890327454},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.5460000038146973},{"id":"https://openalex.org/keywords/hypoxic-pulmonary-vasoconstriction","display_name":"hypoxic pulmonary vasoconstriction","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6882268190383911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.683372437953949},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6727811098098755},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6003574728965759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5399091839790344},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5091883540153503},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48574239015579224},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46135377883911133},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4140751361846924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35531604290008545},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16474059224128723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1072763204574585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-199606000-00008","doi":"https://doi.org/10.1097/00003246-199606000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199606000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:8681592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8681592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1466072718","display_name":"COUPLING OF EXTERNAL TO CELLULAR RESPIRATION","funder_award_id":"R01HL011907","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7976892521","display_name":"MECHANISMS OF EXERCISE MODULATION OF HUMAN GROWTH","funder_award_id":"R01HD026939","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1882000641","https://openalex.org/W1963631192","https://openalex.org/W1970110248","https://openalex.org/W1982013680","https://openalex.org/W1989384369","https://openalex.org/W1992431456","https://openalex.org/W2005735275","https://openalex.org/W2018916579","https://openalex.org/W2037814442","https://openalex.org/W2040750020","https://openalex.org/W2043813981","https://openalex.org/W2055661199","https://openalex.org/W2075425108","https://openalex.org/W2075931967","https://openalex.org/W2077551460","https://openalex.org/W2084114117","https://openalex.org/W2088949488","https://openalex.org/W2100480253","https://openalex.org/W2134812217","https://openalex.org/W2156195262","https://openalex.org/W2162354637","https://openalex.org/W2174350605","https://openalex.org/W2224418909","https://openalex.org/W2406760498"],"related_works":["https://openalex.org/W2063650338","https://openalex.org/W2084114117","https://openalex.org/W2156195262","https://openalex.org/W4231241273","https://openalex.org/W2093127412","https://openalex.org/W4249645686","https://openalex.org/W1991260292","https://openalex.org/W2063840332","https://openalex.org/W2657207404","https://openalex.org/W4386571017"],"abstract_inverted_index":{"OBJECTIVES:":[0],"We":[1,48],"examined":[2],"the":[3,11,91,98,154,174,204,214,219,223,227,241,263,270,300,310,314,324,338],"effect":[4,287],"of":[5,8,114,203,226,288,295,343],"7":[6,131],"days":[7],"hypoxia":[9,128,280,289,344],"in":[10,66,108,173,213,240,253,262,269,279,299,309,323,337],"newborn":[12,82],"rat":[13,83],"on:":[14],"a)":[15,318],"body,":[16],"heart,":[17,29,325],"and":[18,30,35,44,56,59,63,94,139,144,169,243,246,326,331],"lung":[19,37,145,228,244,271,301],"growth;":[20],"b)":[21,340],"circulating":[22],"insulin-like":[23],"growth":[24,58,172],"factor-I":[25],"(IGF-I);":[26],"c)":[27],"lung,":[28,138],"liver":[31],"IGF-I":[32,38,45,61,141,146,168,255,266,296,311,321,329,332],"gene":[33,42,62],"expression;":[34],"d)":[36],"type":[39,147,333],"1":[40,148,334],"receptor":[41,46,64,149,267,335],"expression":[43,65],"binding.":[47],"hypothesize":[49],"that":[50],"hypoxic":[51,175,215],"exposure":[52],"would":[53],"modify":[54],"body":[55],"organ":[57,68],"alter":[60],"an":[67,112],"specific":[69,291,304],"manner.":[70],"DESIGN:":[71],"Randomized,":[72],"controlled":[73],"prospective":[74],"study.":[75],"SETTING:":[76],"University":[77],"research":[78],"laboratory.":[79],"SUBJECTS:":[80],"Eleven":[81],"litters":[84,96],"(n":[85],"=":[86],"10":[87],"per":[88],"litter)":[89],"comprised":[90,97],"hypoxia-exposed":[92],"group":[93,100,121,176],"11":[95],"control":[99],"(room":[101],"air).":[102],"INTERVENTIONS:":[103],"Hypoxia-group":[104],"rats":[105,122],"were":[106,151,161,236,258],"placed":[107],"a":[109],"chamber":[110],"with":[111,167,218,282,313],"FIO2":[113],"0.12":[115],"on":[116,290,345],"postnatal":[117],"day":[118],"1.":[119],"Control":[120],"breathed":[123],"room":[124],"air.":[125],"Exposure":[126],"to":[127],"continued":[129],"for":[130,163],"days.":[132],"MEASUREMENTS":[133],"AND":[134],"MAIN":[135],"RESULTS:":[136],"Hepatic,":[137],"cardiac":[140],"mRNA":[142,150,234,256,268,322,330,336],"levels":[143],"analyzed,":[152],"using":[153],"ribonuclease":[155],"protection":[156],"assay.":[157],"Crude":[158],"membrane":[159],"extracts":[160],"used":[162],"competitive":[164],"binding":[165,294,305],"studies":[166],"insulin.":[170],"Somatic":[171],"was":[177,206,229,272,285,306],"reduced":[178],"by":[179,208,274],"22%":[180],"(final":[181],"weight:":[182],"hypoxic,":[183],"14.8":[184],"+/-":[185,190],"1.2":[186],"g;":[187,192],"control,":[188],"17.1":[189],"1.5":[191],"p":[193,249],"<":[194,211,250,277],".001).":[195],"The":[196,265,341],"relative":[197,224],"weight":[198,201,225],"(organ":[199],"weight/body":[200],"[mg/g])":[202],"heart":[205,242],"increased":[207,238,273,320,327],"39%":[209],"(p":[210,276],".001)":[212],"pups":[216],"compared":[217,281,312],"normoxic":[220],"animals,":[221],"while":[222],"unchanged.":[230],"With":[231],"hypoxia,":[232],"IFG-I":[233,346],"concentrations":[235,257],"significantly":[237,260],"both":[239,328],"(30%":[245],"33%,":[247],"respectively,":[248],".02);":[251],"but,":[252],"contrast,":[254],"not":[259],"different":[261],"liver.":[264],"200%":[275],".02)":[278],"controls.":[283],"There":[284],"no":[286],"or":[292,297],"nonspecific":[293],"insulin":[298,315],"tissue.":[302],"However,":[303],"33%":[307],"greater":[308],"experiments.":[316],"CONCLUSIONS:":[317],"Hypoxia":[319],"lung.":[339],"effects":[342],"are":[347],"tissue-specific.":[348]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
