{"id":"https://openalex.org/W1986558398","doi":"https://doi.org/10.1016/0306-9877(87)90007-7","title":"Reduction of a disulfide bond by \u03b2-adrenergic agonists: Evidence in support of a general \u201creductive activation\u201d hypothesis for the mechanism of action of adrenergic agents","display_name":"Reduction of a disulfide bond by \u03b2-adrenergic agonists: Evidence in support of a general \u201creductive activation\u201d hypothesis for the mechanism of action of adrenergic agents","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W1986558398","doi":"https://doi.org/10.1016/0306-9877(87)90007-7","mag":"1986558398","pmid":"https://pubmed.ncbi.nlm.nih.gov/2882407"},"language":"en","primary_location":{"id":"doi:10.1016/0306-9877(87)90007-7","doi":"https://doi.org/10.1016/0306-9877(87)90007-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-9877(87)90007-7","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113489249","display_name":"Douglas A. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A. Peterson","raw_affiliation_strings":["Research Division, Veterans Administration Medical Centre, 54th Street and 48th Avenue S., Minneapolis, Minnesota, 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Veterans Administration Medical Centre, 54th Street and 48th Avenue S., Minneapolis, Minnesota, 55417, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210140408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111858583","display_name":"Jon M. Gerrard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon M. Gerrard","raw_affiliation_strings":["Manitoba Institute of Cell Biology, 100 Olivia Street, Winnipeg, Manitoba, R3E 0V9 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manitoba Institute of Cell Biology, 100 Olivia Street, Winnipeg, Manitoba, R3E 0V9 USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":0.232,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.41691696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"1","first_page":"45","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-agonists","display_name":"beta-adrenergic agonists","score":0.9860000014305115},{"id":"https://openalex.org/keywords/disulfide-reduction","display_name":"disulfide bond reduction","score":0.984000027179718},{"id":"https://openalex.org/keywords/dtnb","display_name":"DTNB","score":0.7580000162124634},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.878000020980835},{"id":"https://openalex.org/keywords/gtp-binding","display_name":"GTP binding","score":0.8119999766349792},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2777426643","wikidata":"https://www.wikidata.org/wiki/Q17915090","display_name":"DTNB","level":4,"score":0.8138659000396729},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.746494710445404},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7211498022079468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6559922695159912},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5294285416603088},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.511139452457428},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4988224506378174},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.471846342086792},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.45708441734313965},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4322950839996338},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.4287317991256714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35072147846221924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34277498722076416},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3424205780029297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3368071913719177},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2613477110862732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1986466348171234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07608479261398315},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004228","descriptor_name":"Dithionitrobenzoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-9877(87)90007-7","doi":"https://doi.org/10.1016/0306-9877(87)90007-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-9877(87)90007-7","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:2882407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2882407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1480412527","https://openalex.org/W1488437431","https://openalex.org/W1582593880","https://openalex.org/W1604652736","https://openalex.org/W1968230940","https://openalex.org/W1978531872","https://openalex.org/W1994910406","https://openalex.org/W1996675954","https://openalex.org/W2006370393","https://openalex.org/W2009934288","https://openalex.org/W2039849556","https://openalex.org/W2054530630","https://openalex.org/W2091409146","https://openalex.org/W2416237023","https://openalex.org/W2936343242","https://openalex.org/W3194342606","https://openalex.org/W4406984856"],"related_works":["https://openalex.org/W2936343242","https://openalex.org/W2054530630","https://openalex.org/W2405652592","https://openalex.org/W2104349140","https://openalex.org/W2017443275","https://openalex.org/W2091409146","https://openalex.org/W2416422477","https://openalex.org/W1980776106","https://openalex.org/W2035902417","https://openalex.org/W2089910480"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}