{"id":"https://openalex.org/W1986554545","doi":"https://doi.org/10.1016/0014-5793(89)80475-2","title":"Analysis of murine interferon\u2010\u03b3 binding to its receptor on intact cells and solubilized membranes Identification of an 80 kDa receptor","display_name":"Analysis of murine interferon\u2010\u03b3 binding to its receptor on intact cells and solubilized membranes Identification of an 80 kDa receptor","publication_year":1989,"publication_date":"1989-01-02","ids":{"openalex":"https://openalex.org/W1986554545","doi":"https://doi.org/10.1016/0014-5793(89)80475-2","mag":"1986554545","pmid":"https://pubmed.ncbi.nlm.nih.gov/2521607"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(89)80475-2","doi":"https://doi.org/10.1016/0014-5793(89)80475-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(89)80475-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2889%2980475-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2889%2980475-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072330423","display_name":"Franca Cofano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Cofano","raw_affiliation_strings":["National Cancer Institute, Bethesda, Maryland 20892","National Cancer Institute, Bethesda, maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024383373","display_name":"Santo Landolfo","orcid":"https://orcid.org/0000-0002-3153-2865","observed_orcids":["https://orcid.org/0000-0002-3153-2865","https://orcid.org/0009-0008-0448-4272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Landolfo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"]E. Appella","raw_affiliation_strings":["National Cancer Institute, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109234910","display_name":"S J Ullrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S.J. Ullrich","raw_affiliation_strings":["Institute of Microbiology, Medical School, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Medical School, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.5174,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69307127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"242","issue":"2","first_page":"233","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.2354000061750412,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/el4-thymoma-cells","display_name":"EL4 thymoma cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/receptor-molecular-mass","display_name":"receptor molecular mass","score":0.6019999980926514},{"id":"https://openalex.org/keywords/detergent-solubilization","display_name":"detergent solubilization","score":0.7900000214576721},{"id":"https://openalex.org/keywords/chaps","display_name":"CHAPS","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2778336440","wikidata":"https://www.wikidata.org/wiki/Q1062810","display_name":"Chaps","level":3,"score":0.832190752029419},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7524087429046631},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.6993789672851562},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6182423830032349},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.5920473337173462},{"id":"https://openalex.org/C4863142","wikidata":"https://www.wikidata.org/wiki/Q907920","display_name":"Solubilization","level":2,"score":0.5535792708396912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5476412773132324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5354039669036865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4353080987930298},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4271796941757202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3425058126449585},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12890776991844177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000345","descriptor_name":"Affinity Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(89)80475-2","doi":"https://doi.org/10.1016/0014-5793(89)80475-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(89)80475-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2889%2980475-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:2521607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2521607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(89)80475-2","doi":"https://doi.org/10.1016/0014-5793(89)80475-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(89)80475-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2889%2980475-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1986554545.pdf"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1521897480","https://openalex.org/W1550951408","https://openalex.org/W1554406306","https://openalex.org/W1588572292","https://openalex.org/W1976707296","https://openalex.org/W1980751318","https://openalex.org/W1990880840","https://openalex.org/W1991909103","https://openalex.org/W2024399865","https://openalex.org/W2030441513","https://openalex.org/W2077404846","https://openalex.org/W2095657538","https://openalex.org/W2124959718","https://openalex.org/W2142482364"],"related_works":["https://openalex.org/W2034308851","https://openalex.org/W2077404846","https://openalex.org/W1560206692","https://openalex.org/W2124959718","https://openalex.org/W1668274701","https://openalex.org/W2070124458","https://openalex.org/W28728343","https://openalex.org/W2142482364","https://openalex.org/W2079087011","https://openalex.org/W1482158720"],"abstract_inverted_index":{"The":[0,108],"receptor":[1,38,61,81],"for":[2,8],"murine-interferon-gamma":[3],"(Mu-IFN-gamma)":[4],"has":[5,32],"been":[6],"characterized":[7],"its":[9,68],"molecular":[10,76,119],"size":[11],"and":[12,28,47,96],"equilibrium":[13],"binding":[14,69],"constant":[15],"on":[16,82,102],"a":[17,34,63,91],"thymoma":[18],"cell":[19],"line,":[20],"EL-4.":[21],"Binding":[22],"of":[23,37,42,58,74,78,105,114,121],"125I-IFN-gamma":[24],"to":[25],"intact":[26,83],"cells":[27,84],"their":[29],"solubilized":[30,106],"membranes":[31,87],"shown":[33,55],"single":[35],"class":[36],"with":[39,62,99],"Kd":[40],"values":[41],"1.9":[43],"x":[44,49],"10(-9)":[45],"M":[46],"1.3":[48],"10(-8)":[50],"M,":[51],"respectively.":[52],"It":[53],"was":[54,88],"that":[56,111],"solubilization":[57],"the":[59,75,79],"Mu-IFN-gamma":[60,80],"Zwitterionic":[64],"detergent":[65],"(Chaps)":[66],"preserves":[67],"activity.":[70],"A":[71],"direct":[72,97],"comparison":[73],"mass":[77,120],"versus":[85],"detergent-solubilized":[86],"performed":[89],"using":[90],"radiolabeled":[92],"photoactivated":[93],"crosslinking":[94],"reagent":[95],"hybridization":[98],"125I-labeled":[100],"IFN-gamma":[101],"Western":[103],"blots":[104],"receptor.":[107],"results":[109],"indicate":[110],"both":[112],"types":[113],"receptors":[115],"have":[116],"an":[117],"identical":[118],"approximately":[122],"80":[123],"kDa.":[124]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
