{"id":"https://openalex.org/W1986483382","doi":"https://doi.org/10.1021/bi00044a041","title":"Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils","display_name":"Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W1986483382","doi":"https://doi.org/10.1021/bi00044a041","mag":"1986483382","pmid":"https://pubmed.ncbi.nlm.nih.gov/7578068"},"language":"en","primary_location":{"id":"doi:10.1021/bi00044a041","doi":"https://doi.org/10.1021/bi00044a041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00044a041","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["Department of Anesthesia, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022770931","display_name":"Jane F. Maddox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane F. Maddox","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089915907","display_name":"Nicos A. Petasis","orcid":"https://orcid.org/0000-0002-8864-4446","observed_orcids":["https://orcid.org/0000-0002-8864-4446"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicos A. Petasis","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072660662","display_name":"Irini Akritopoulou\u2010Zanze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irini Akritopoulou-Zanze","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103364740","display_name":"Aikaterina Papayianni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aikaterina Papayianni","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049852436","display_name":"Hugh R. Brady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh R. Brady","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049650132","display_name":"Sean P. Colgan","orcid":"https://orcid.org/0000-0003-0431-8887","observed_orcids":["https://orcid.org/0000-0003-0431-8887"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean P. Colgan","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109841136","display_name":"James Madara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Madara","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.3908,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.96220728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"34","issue":"44","first_page":"14609","last_page":"14615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoxin-a4","display_name":"lipoxin A4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.7900000214576721},{"id":"https://openalex.org/keywords/15-hydroxyprostaglandin-dehydrogenase","display_name":"15-hydroxyprostaglandin dehydrogenase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neutrophil-transmigration","display_name":"neutrophil transmigration","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammation-regulation","display_name":"inflammation regulation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/epithelial-monolayers","display_name":"epithelial monolayers","score":0.6650000214576721},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2780415110","wikidata":"https://www.wikidata.org/wiki/Q4329","display_name":"Lipoxin","level":3,"score":0.6984660625457764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6660679578781128},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5731241106987},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.46628332138061523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4595038592815399},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4389488995075226},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41151729226112366},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2921346127986908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1968129277229309},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08093726634979248},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07008621096611023}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044045","descriptor_name":"Lipoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00044a041","doi":"https://doi.org/10.1021/bi00044a041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00044a041","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7578068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7578068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G301977313","display_name":null,"funder_award_id":"GM 38765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7317681182","display_name":"THE PHAGOCYTE MEMBRANE","funder_award_id":"P01DK050305","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7979141929","display_name":"Epithelial-Neutrophil Interactions in IBD","funder_award_id":"R01DK047662","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1558560534","https://openalex.org/W2037697142","https://openalex.org/W2080188146","https://openalex.org/W2083041617","https://openalex.org/W1974309015","https://openalex.org/W2043559255","https://openalex.org/W1996615849","https://openalex.org/W2133075832","https://openalex.org/W4413769960","https://openalex.org/W2120308746"],"abstract_inverted_index":{"Lipoxins":[0],"(LX)":[1],"are":[2],"bioactive":[3],"eicosanoids":[4],"that":[5,38,51,128,153],"carry":[6],"a":[7],"tetraene":[8],"structure":[9],"and":[10,22,60,101,108,141,164,171],"serve":[11],"as":[12,41,117,119],"regulators":[13],"of":[14,75,146],"inflammation,":[15],"in":[16,162,165],"part":[17],"by":[18,29,55,77],"inhibiting":[19],"neutrophil":[20,110],"migration":[21],"adhesion.":[23],"Lipoxin":[24],"A4":[25],"is":[26,68],"rapidly":[27],"regulated":[28],"conversion":[30,54,76],"to":[31,104,121,137,142,167],"inactive":[32],"LX":[33],"metabolites":[34],"via":[35],"local":[36],"metabolism":[37],"involves":[39],"dehydrogenation":[40],"the":[42,93,150],"predominant":[43],"route.":[44],"Here,":[45],"several":[46],"LXA4":[47,67,81,91,95,106,129,154,169],"analogs":[48,130,156],"were":[49],"designed":[50,133],"resisted":[52],"rapid":[53,139],"both":[56,161],"differentiated":[57],"HL-60":[58],"cells":[59],"recombinant":[61,78],"15-hydroxyprostaglandin":[62],"dehydrogenase,":[63],"systems":[64],"where":[65],"native":[66,147],"degraded":[69],"within":[70],"minutes.":[71],"The":[72],"rank":[73],"order":[74],"dehydrogenase":[79],"was":[80],"methyl":[82,88],"ester":[83,89],">":[84,90],"PGE2":[85,87],"approximately":[86],">>>":[92],"novel":[94],"analogs.":[96],"In":[97],"addition,":[98],"15(R/S)-methyl-LXA4,":[99],"15-cyclohexyl-LXA4,":[100],"16-phenoxy-LXA4":[102],"proved":[103],"retain":[105,143],"bioactivity":[107],"inhibited":[109],"transmigration":[111],"across":[112],"polarized":[113],"epithelial":[114],"cell":[115],"monolayers":[116],"well":[118],"adhesion":[120],"vascular":[122],"endothelial":[123],"cells.":[124],"These":[125],"results":[126,151],"indicate":[127],"can":[131,157],"be":[132,158],"using":[134],"these":[135],"criteria":[136],"resist":[138],"transformation":[140],"biological":[144],"actions":[145,170],"LXA4.":[148],"Moreover,":[149],"suggest":[152],"stable":[155],"useful":[159],"tools":[160],"vitro":[163],"vivo":[166],"evaluate":[168],"therapeutic":[172],"potential.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}