{"id":"https://openalex.org/W1986394012","doi":"https://doi.org/10.4265/bio.16.149","title":"The Antimicrobial Activity, Hydrophobicity and Toxicity of Tri(n-Alkyl)sulfoniums and Tris(n-Alkylphenyl) sulfoniums, and Their Relationships","display_name":"The Antimicrobial Activity, Hydrophobicity and Toxicity of Tri(n-Alkyl)sulfoniums and Tris(n-Alkylphenyl) sulfoniums, and Their Relationships","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1986394012","doi":"https://doi.org/10.4265/bio.16.149","mag":"1986394012","pmid":"https://pubmed.ncbi.nlm.nih.gov/22190437"},"language":"en","primary_location":{"id":"doi:10.4265/bio.16.149","doi":"https://doi.org/10.4265/bio.16.149","is_oa":true,"landing_page_url":"https://doi.org/10.4265/bio.16.149","pdf_url":"https://www.jstage.jst.go.jp/article/bio/16/4/16_4_149/_pdf","source":{"id":"https://openalex.org/S138294073","display_name":"Biocontrol Science","issn_l":"1342-4815","issn":["1342-4815","1884-0205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocontrol Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bio/16/4/16_4_149/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063286458","display_name":"Michiasa Hirayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948482138","display_name":"Fujifilm (Japan)","ror":"https://ror.org/0493bmq37","country_code":"JP","type":"company","lineage":["https://openalex.org/I2948482138"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"MICHIASA HIRAYAMA","raw_affiliation_strings":["Safety Evaluation Center Ecology and Quality Management Div. CSR Div., Fujifilm Corporation, Minamiashigara, Kanagawa 250-0193, Japan. michiasa_hirayama@fujifilm.co.jp","Safety Evaluation Center Ecology and Quality Management Div. CSR Div., Fujifilm Corporation, Minamiashigara, Kanagawa 250-0193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety Evaluation Center Ecology and Quality Management Div. CSR Div., Fujifilm Corporation, Minamiashigara, Kanagawa 250-0193, Japan. michiasa_hirayama@fujifilm.co.jp","institution_ids":["https://openalex.org/I2948482138"]},{"raw_affiliation_string":"Safety Evaluation Center Ecology and Quality Management Div. CSR Div., Fujifilm Corporation, Minamiashigara, Kanagawa 250-0193, Japan","institution_ids":["https://openalex.org/I2948482138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063286458"],"corresponding_institution_ids":["https://openalex.org/I2948482138"],"apc_list":null,"apc_paid":null,"fwci":0.183,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45468962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"16","issue":"4","first_page":"149","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfonium-compounds","display_name":"sulfonium compounds","score":0.6779999732971191},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/clogp","display_name":"ClogP","score":0.925000011920929},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.75},{"id":"https://openalex.org/keywords/acute-oral-toxicity","display_name":"acute oral toxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.871999979019165},{"id":"https://openalex.org/keywords/skin-corrosion","display_name":"skin corrosion","score":0.7049999833106995},{"id":"https://openalex.org/keywords/quaternary-ammonium-salts","display_name":"quaternary ammonium compounds","score":0.9900000095367432},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7940802574157715},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7447834014892578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7001250982284546},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5808817148208618},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.5020911693572998},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4692169427871704},{"id":"https://openalex.org/C3019129585","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Skin irritation","level":2,"score":0.46213144063949585},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.45747989416122437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3941563367843628},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27777040004730225},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24009954929351807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12901344895362854},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013452","descriptor_name":"Sulfonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013452","descriptor_name":"Sulfonium Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013452","descriptor_name":"Sulfonium Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4265/bio.16.149","doi":"https://doi.org/10.4265/bio.16.149","is_oa":true,"landing_page_url":"https://doi.org/10.4265/bio.16.149","pdf_url":"https://www.jstage.jst.go.jp/article/bio/16/4/16_4_149/_pdf","source":{"id":"https://openalex.org/S138294073","display_name":"Biocontrol Science","issn_l":"1342-4815","issn":["1342-4815","1884-0205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocontrol Science","raw_type":"journal-article"},{"id":"pmid:22190437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22190437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocontrol science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4265/bio.16.149","doi":"https://doi.org/10.4265/bio.16.149","is_oa":true,"landing_page_url":"https://doi.org/10.4265/bio.16.149","pdf_url":"https://www.jstage.jst.go.jp/article/bio/16/4/16_4_149/_pdf","source":{"id":"https://openalex.org/S138294073","display_name":"Biocontrol Science","issn_l":"1342-4815","issn":["1342-4815","1884-0205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biocontrol Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986394012.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W26660148","https://openalex.org/W106105153","https://openalex.org/W1489601464","https://openalex.org/W1656436309","https://openalex.org/W1964729421","https://openalex.org/W1971090699","https://openalex.org/W1981284264","https://openalex.org/W1988710481","https://openalex.org/W1990057891","https://openalex.org/W2014000334","https://openalex.org/W2033495141","https://openalex.org/W2044728970","https://openalex.org/W2051207046","https://openalex.org/W2055159321","https://openalex.org/W2058773538","https://openalex.org/W2131565767","https://openalex.org/W2314663805","https://openalex.org/W2512344406","https://openalex.org/W2952768989","https://openalex.org/W3049126474"],"related_works":["https://openalex.org/W1981218579","https://openalex.org/W1971090699","https://openalex.org/W3123083876","https://openalex.org/W3195633787","https://openalex.org/W2078179153","https://openalex.org/W1997978363","https://openalex.org/W2921561859","https://openalex.org/W3177114599","https://openalex.org/W4414709763","https://openalex.org/W2949084702"],"abstract_inverted_index":{"The":[0,17,52,70,83,98],"antimicrobial":[1,18,53,165],"activity,":[2],"hydrophobicity":[3],"and":[4,9,12,36,39,75,111,113,135,177,195],"toxicity":[5,86,134,179],"of":[6,55,63,72,139,147,167,175,192],"tri(n-alkyl)sulfoniums":[7],"(TASs)":[8],"tris{4-(n-alkylphenyl)}sulfoniums":[10],"(TAPSs),":[11],"their":[13],"relationships":[14],"were":[15,59,142,171],"investigated.":[16],"activity":[19],"against":[20],"the":[21,28,31,44,47,56,64,73,76,89,92,95,103,106,120,123,132,136,140,148,156,164,168,178,193],"tested":[22],"strains":[23],"tended":[24],"to":[25,80,158],"increase":[26,29,45,90,104,121],"with":[27,43,88,102,119],"in":[30,46,49,91,94,105,122,125,188],"sulfonium":[32],"ClogP":[33,48,68,93,107,124],"between":[34,108],"7":[35,110],"approximately":[37,109],"12":[38],"beyond":[40,114],"that":[41,115,131],"decreased":[42,87,116],"both":[50,96,126],"sulfoniums.":[51,97,127],"activities":[54,166],"most":[57],"TAPSs":[58,77,141],"higher":[60,144,172],"than":[61,145,173],"those":[62,146,174],"TASs":[65,74,149],"at":[66,150],"similar":[67,118,152],"values.":[69],"mutagenicity":[71],"was":[78,180],"judged":[79],"be":[81,186],"negative.":[82],"acute":[84,133],"oral":[85],"skin":[99,137],"irritation/corrosion":[100,138],"increased":[101],"12,":[112],"or":[117],"It":[128],"is":[129],"noted":[130],"clearly":[143],"a":[151],"ClogP.":[153],"In":[154],"comparing":[155],"sulfoniums":[157,170,184],"representative":[159],"quaternary":[160],"ammonium":[161],"compounds":[162],"(QACs),":[163],"some":[169,183],"QACs":[176],"lower.":[181],"Therefore,":[182],"could":[185],"utilized":[187],"many":[189],"fields":[190],"instead":[191],"presently":[194],"widely-used":[196],"QACs.":[197]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}