{"id":"https://openalex.org/W1986376992","doi":"https://doi.org/10.1074/jbc.272.32.20152","title":"Energetically Unfavorable Interactions among the Zinc Fingers of Transcription Factor IIIA When Bound to the 5 S rRNA Gene","display_name":"Energetically Unfavorable Interactions among the Zinc Fingers of Transcription Factor IIIA When Bound to the 5 S rRNA Gene","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W1986376992","doi":"https://doi.org/10.1074/jbc.272.32.20152","mag":"1986376992","pmid":"https://pubmed.ncbi.nlm.nih.gov/9242690"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.32.20152","doi":"https://doi.org/10.1074/jbc.272.32.20152","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.32.20152","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.32.20152","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062684664","display_name":"David G. Kehres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Kehres","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA","From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059742158","display_name":"Girish S. Subramanyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girish S. Subramanyan","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111640054","display_name":"Virginia S. Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia S. Hung","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"George W. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George W. Rogers","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036844367","display_name":"David R. Setzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David R. Setzer","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland,\u2009Ohio\u200944106","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036844367"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.7111,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67060658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"272","issue":"32","first_page":"20152","last_page":"20161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tfiiia","display_name":"TFIIIA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.828000009059906},{"id":"https://openalex.org/keywords/5s-rdna","display_name":"5S rDNA","score":0.9440000057220459},{"id":"https://openalex.org/keywords/internal-control-region","display_name":"internal control region","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-bending","display_name":"DNA bending","score":0.675000011920929},{"id":"https://openalex.org/keywords/protein-dna-complex","display_name":"protein-DNA complex","score":0.621999979019165},{"id":"https://openalex.org/keywords/binding-thermodynamics","display_name":"binding thermodynamics","score":0.5889999866485596},{"id":"https://openalex.org/keywords/xenopus","display_name":"Xenopus","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.8085074424743652},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6108430027961731},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5770785808563232},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5587418079376221},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49592575430870056},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4826710522174835},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4583399295806885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.456000953912735},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.4346199333667755},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41090309619903564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3839568495750427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34615179896354675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3383381962776184},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33814865350723267},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012341","descriptor_name":"RNA, Ribosomal, 5S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035582","descriptor_name":"Transcription Factor TFIIIA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.32.20152","doi":"https://doi.org/10.1074/jbc.272.32.20152","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.32.20152","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9242690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9242690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.32.20152","doi":"https://doi.org/10.1074/jbc.272.32.20152","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.32.20152","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4505504637","display_name":null,"funder_award_id":"GM-48035","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4621569271","display_name":"Transcription Factor IIIA","funder_award_id":"R01GM048035","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1038211084","https://openalex.org/W1482729845","https://openalex.org/W1504141518","https://openalex.org/W1531234455","https://openalex.org/W1597423304","https://openalex.org/W1762875852","https://openalex.org/W1780540337","https://openalex.org/W1873199501","https://openalex.org/W1956989253","https://openalex.org/W1964006283","https://openalex.org/W1967598896","https://openalex.org/W1973080393","https://openalex.org/W1973763076","https://openalex.org/W1974266455","https://openalex.org/W1975057427","https://openalex.org/W1976459530","https://openalex.org/W1983309341","https://openalex.org/W1988159427","https://openalex.org/W1988836624","https://openalex.org/W1989372611","https://openalex.org/W1995246183","https://openalex.org/W1997706668","https://openalex.org/W2002107168","https://openalex.org/W2002515925","https://openalex.org/W2006624258","https://openalex.org/W2007272508","https://openalex.org/W2007490638","https://openalex.org/W2009821284","https://openalex.org/W2011198690","https://openalex.org/W2020542035","https://openalex.org/W2023257749","https://openalex.org/W2030333654","https://openalex.org/W2031682614","https://openalex.org/W2032205265","https://openalex.org/W2038597359","https://openalex.org/W2039292958","https://openalex.org/W2040487729","https://openalex.org/W2041601475","https://openalex.org/W2042359837","https://openalex.org/W2042765757","https://openalex.org/W2044900718","https://openalex.org/W2051520229","https://openalex.org/W2053801865","https://openalex.org/W2055134764","https://openalex.org/W2055488548","https://openalex.org/W2058720015","https://openalex.org/W2061162943","https://openalex.org/W2062104167","https://openalex.org/W2067765294","https://openalex.org/W2084234979","https://openalex.org/W2085732532","https://openalex.org/W2090889370","https://openalex.org/W2099051060","https://openalex.org/W2109448523","https://openalex.org/W2119692824","https://openalex.org/W2124100270","https://openalex.org/W2132291850","https://openalex.org/W2137585149","https://openalex.org/W2139721361","https://openalex.org/W2140771972","https://openalex.org/W2146081591","https://openalex.org/W2330567837","https://openalex.org/W2888511473"],"related_works":["https://openalex.org/W1967598896","https://openalex.org/W2140771972","https://openalex.org/W1989372611","https://openalex.org/W2055488548","https://openalex.org/W2039292958","https://openalex.org/W2015001952","https://openalex.org/W2027637346","https://openalex.org/W1988836624","https://openalex.org/W2084234979","https://openalex.org/W1780540337"],"abstract_inverted_index":{"Xenopus":[0],"transcription":[1],"factor":[2],"IIIA":[3],"(TFIIIA)":[4],"binds":[5,153],"to":[6,87,154,208,264],"over":[7],"50":[8],"base":[9],"pairs":[10,136],"in":[11,174,190,251],"the":[12,17,23,51,54,59,155,162,172,175,186,191,203,238,241,252,254,266],"internal":[13,242],"control":[14,243],"region":[15,244],"of":[16,53,63,74,118,137,171,185,202,217,221,235,240],"5":[18,156,255],"S":[19,157,177,193,256],"rRNA":[20,158,178,194,257],"gene,":[21,258],"yet":[22],"binding":[24,56,88,112,211,223],"energy":[25,57],"for":[26],"this":[27],"interaction":[28],"(DeltaG0":[29],"=":[30],"-12.8":[31],"kcal/mol)":[32],"is":[33,206,262],"no":[34],"greater":[35],"than":[36],"that":[37,42,82,110,143,161,205,261],"exhibited":[38],"by":[39,113,212,224],"many":[40],"proteins":[41,134],"occupy":[43],"much":[44],"smaller":[45],"DNA":[46,55,204,222],"targets.":[47],"Despite":[48],"considerable":[49],"study,":[50],"distribution":[52],"among":[58],"various":[60,267],"zinc":[61,76,116,149,215],"fingers":[62,117,150,167,216],"TFIIIA":[64,70,119,152,225],"remains":[65],"poorly":[66],"understood.":[67],"By":[68],"analyzing":[69],"mutants":[71],"with":[72],"disruptions":[73],"individual":[75,232],"fingers,":[77,139],"we":[78,140],"have":[79],"previously":[80],"shown":[81],"each":[83],"finger":[84],"contributes":[85],"favorably":[86],"(Del":[89],"Rio,":[90],"S.,":[91],"Menezes,":[92],"S.":[93],"R.,":[94],"and":[95,129,132,160,245],"Setzer,":[96],"D.":[97],"R.":[98],"(1993)":[99],"J.":[100],"Mol.":[101],"Biol.":[102],"233,":[103],"567-579).":[104],"Those":[105],"results":[106],"also":[107],"suggested,":[108],"however,":[109],"simultaneous":[111,210],"all":[114,213],"nine":[115,214],"may":[120,197],"involve":[121],"a":[122,229],"substantial":[123],"energetic":[124,144],"cost.":[125],"Using":[126],"complementary":[127],"N-":[128],"C-terminal":[130],"fragments":[131],"full-length":[133],"containing":[135],"disrupted":[138],"now":[141],"show":[142],"interference":[145,164],"indeed":[146],"occurs":[147,165],"between":[148,166,231],"when":[151],"gene":[159,179,195],"greatest":[163],"at":[168],"opposite":[169],"ends":[170],"protein":[173],"TFIIIA.5":[176,192],"complex.":[180],"Some,":[181],"but":[182],"not":[183],"all,":[184],"thermodynamically":[187],"unfavorable":[188],"strain":[189,248],"complex":[196],"be":[198],"derived":[199],"from":[200],"bending":[201],"necessary":[207,263],"accommodate":[209,265],"TFIIIA.":[218],"The":[219],"energetics":[220],"thus":[226],"emerges":[227],"as":[228],"compromise":[230],"favorable":[233],"contacts":[234],"importance":[236],"along":[237],"length":[239],"long":[246],"range":[247],"or":[249,259],"distortion":[250],"protein,":[253],"both":[260],"local":[268],"interactions.":[269]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}