{"id":"https://openalex.org/W1986376486","doi":"https://doi.org/10.1093/carcin/12.11.2099","title":"Spectroscopic characteristics and site I/site II classification of cis and trans benzo[a]pyrene diolepoxide enantiomer-guanosine adducts in oligonucleotides and plynucleotides","display_name":"Spectroscopic characteristics and site I/site II classification of cis and trans benzo[a]pyrene diolepoxide enantiomer-guanosine adducts in oligonucleotides and plynucleotides","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W1986376486","doi":"https://doi.org/10.1093/carcin/12.11.2099","mag":"1986376486","pmid":"https://pubmed.ncbi.nlm.nih.gov/1934295"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/12.11.2099","doi":"https://doi.org/10.1093/carcin/12.11.2099","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/12.11.2099","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018460703","display_name":"Nicholas E. Geacintov","orcid":"https://orcid.org/0000-0002-7961-2231","observed_orcids":["https://orcid.org/0000-0002-7961-2231"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Geacintov","raw_affiliation_strings":["Chemistry Department, New York University, NY 10003","Chemistry Dept., New York University, NY 10003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, New York University, NY 10003","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Chemistry Dept., New York University, NY 10003","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918093","display_name":"Monique Cosman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique Cosman","raw_affiliation_strings":["The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103487846","display_name":"Bing Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Mao","raw_affiliation_strings":["The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058255561","display_name":"Anna Alfano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Alfano","raw_affiliation_strings":["The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020391200","display_name":"V\u00edctor Ib\u00e1\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Ibanez","raw_affiliation_strings":["The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012263259","display_name":"Ronald G. Harvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Harvey","raw_affiliation_strings":["The Ben May Institute, The University of Chicago Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ben May Institute, The University of Chicago Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.2659,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.78437871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"11","first_page":"2099","last_page":"2108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.5630000233650208},{"id":"https://openalex.org/keywords/fluorescence","display_name":"fluorescence","score":0.7419999837875366},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oligonucleotide-duplexes","display_name":"oligonucleotide duplexes","score":0.734000027179718},{"id":"https://openalex.org/keywords/polynucleotides","display_name":"polynucleotides","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8833014965057373},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.7619088888168335},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6868128776550293},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.6019745469093323},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6005958318710327},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5805046558380127},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5467934608459473},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5363233089447021},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.44294828176498413},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3158450126647949},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09099763631820679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08926430344581604}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011119","descriptor_name":"Polynucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/12.11.2099","doi":"https://doi.org/10.1093/carcin/12.11.2099","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/12.11.2099","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:1934295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1934295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1165892584","display_name":null,"funder_award_id":"CA20851","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1960655883","display_name":null,"funder_award_id":"ES 04732","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5943349538","display_name":"STRUCTURE-FUNCTION OF FJORD PAH CANCINOGEN-DNA ADDUCTS.","funder_award_id":"R01CA020851","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8595431668","display_name":"OLIGONUCLEOTIDE ADDUCTS OF CARCINOGENIC HYDROCARBONS","funder_award_id":"R01ES004732","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033344777","https://openalex.org/W2000926230","https://openalex.org/W2066971816","https://openalex.org/W2113398758","https://openalex.org/W2035527898","https://openalex.org/W2094755318","https://openalex.org/W2016725913","https://openalex.org/W1981832315","https://openalex.org/W1977479828","https://openalex.org/W225454434"],"abstract_inverted_index":{"The":[0,34,69,135,207,244],"highly":[1],"tumorigenic":[2],"isomer":[3],"(+)-7,8-dihydroxy-anti-9,":[4],"10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene":[5],"[(+)-anti-BPDE]":[6],"and":[7,27,40,49,123,151,153,162,175,198,204,249],"its":[8],"non-tumorigenic":[9],"enantiomer":[10],"(-)-anti-BPDE":[11,190],"are":[12,142,215,227,238,257],"known":[13],"to":[14,28,106,173],"react":[15],"predominantly":[16],"with":[17,59,217,229],"the":[18,54,60,73,100,115,124,139,144,149,155,160,169,177,187,220,224,235,240,253],"exocyclic":[19],"amino":[20],"group":[21],"(N2)":[22],"of":[23,31,43,72,82,85,138,143,154,171,189,210,219,239,252],"deoxyguanine":[24],"in":[25,53,64,80,99,111,186,202],"DNA":[26],"form":[29],"adducts":[30,52,76,166,214,226,237],"different":[32],"conformations.":[33,86],"spectroscopic":[35,70,136,208],"characteristics":[36,71,137,248],"(UV":[37],"absorbance,":[38],"fluorescence":[39],"circular":[41],"dichroism)":[42],"stereochemically":[44],"defined":[45],"(+)-trans,":[46],"(-)-trans,":[47,152],"(+)-cis":[48],"(-)-cis":[50,163],"d(5'-CACATGBPDETACAC)":[51],"single-stranded":[55],"form,":[56],"or":[57],"complexed":[58],"complementary":[61],"strand":[62],"d(5'-GTGTACATGTG)":[63],"aqueous":[65],"solution,":[66],"were":[67],"investigated.":[68],"double-stranded":[74],"d(5'-CACATGBPDETACAC).d(5'-GTGTACATGTG)":[75],"can":[77],"be":[78],"interpreted":[79],"terms":[81],"two":[83,254],"types":[84],"In":[87,165],"site":[88,112,145,156,230,241],"I-type":[89],"conformations,":[90,233],"there":[91],"is":[92,104,118,128,182,193],"an":[93],"approximately":[94,120],"10":[95],"nm":[96],"red":[97,116],"shift":[98,117],"absorption":[101],"maxima,":[102],"which":[103],"attributed":[105],"significant":[107],"pyrenyl":[108],"residue-base":[109],"interactions;":[110],"II-type":[113],"adducts,":[114],"only":[119,194],"2-3":[121],"nm,":[122],"pyrene":[125],"ring":[126],"system":[127],"located":[129],"at":[130],"external,":[131],"solvent-exposed":[132],"binding":[133,170],"sites.":[134],"BPDE-modified":[140,212,221],"duplexes":[141],"II":[146,242],"type":[147,158],"for":[148,159],"(+)-":[150,161],"I":[157,231],"adducts.":[164],"derived":[167],"from":[168],"(+)-anti-BPDE":[172],"poly(dG-dC).(dG-dC)":[174,203],"poly(dG).(dC),":[176],"trans/cis":[178],"BPDE-N2-dG":[179],"adduct":[180,232,247],"ratio":[181,192],"6":[183],"+/-":[184,196,200],"1;":[185],"case":[188],"this":[191],"0.4":[195],"0.1":[197],"0.6":[199],"0.15":[201],"poly(dG).(dC)":[205],"respectively.":[206],"properties":[209],"these":[211],"polynucleotide":[213],"consistent":[216],"those":[218],"oligonucleotide":[222],"complexes;":[223],"cis":[225],"correlated":[228],"while":[234],"trans":[236],"type.":[243],"correlations":[245],"between":[246],"biological":[250],"activities":[251],"BPDE":[255],"enantiomers":[256],"discussed.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
