{"id":"https://openalex.org/W1986375333","doi":"https://doi.org/10.1158/1535-7163.mct-05-0274","title":"Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors","display_name":"Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W1986375333","doi":"https://doi.org/10.1158/1535-7163.mct-05-0274","mag":"1986375333","pmid":"https://pubmed.ncbi.nlm.nih.gov/16373704"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-05-0274","doi":"https://doi.org/10.1158/1535-7163.mct-05-0274","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-05-0274","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015327236","display_name":"Lina Albitar","orcid":"https://orcid.org/0000-0002-6060-6886","observed_orcids":["https://orcid.org/0000-0002-6060-6886"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Albitar","raw_affiliation_strings":["Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059647579","display_name":"Laura L. Laidler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura L. Laidler","raw_affiliation_strings":["Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109567926","display_name":"Rony T. Abdallah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rony Abdallah","raw_affiliation_strings":["Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011828487","display_name":"Kimberly Kay Leslie","orcid":"https://orcid.org/0000-0002-2704-8990","observed_orcids":["https://orcid.org/0000-0002-2704-8990"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly K. Leslie","raw_affiliation_strings":["Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology and Biomedical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1748,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77251819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"12","first_page":"1891","last_page":"1899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6259999871253967},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.878000020980835},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.7889999747276306},{"id":"https://openalex.org/keywords/erk1-2-mapk","display_name":"ERK1/2 MAPK","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.7687355279922485},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.705727219581604},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6556937098503113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6242239475250244},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6177146434783936},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5195439457893372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5179547071456909},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4677315652370453},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4585336148738861},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.45490843057632446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43992263078689575},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4306299090385437},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.423861563205719},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41661399602890015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32512015104293823},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25657907128334045},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2513653039932251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18097731471061707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07638236880302429},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.mct-05-0274","doi":"https://doi.org/10.1158/1535-7163.mct-05-0274","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-05-0274","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:16373704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16373704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:ir.uiowa.edu:obgyn_pubs-1041","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/obgyn_pubs/42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Obstetrics and Gynecology Publications","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3829057187","display_name":"FUNCTIONAL PROTEIN ANALYSIS--A SHARED RESOURCE FOR UNM","funder_award_id":"R24CA088339","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4195847870","display_name":"Targeted Therapy for Endometrial Cancer","funder_award_id":"R01CA099908","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G754039670","display_name":null,"funder_award_id":"R01CA99908-1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1498071142","https://openalex.org/W1524333424","https://openalex.org/W1567148937","https://openalex.org/W1603633107","https://openalex.org/W1654438595","https://openalex.org/W1894695711","https://openalex.org/W1949779401","https://openalex.org/W1973071934","https://openalex.org/W1974621892","https://openalex.org/W1975138180","https://openalex.org/W1978436875","https://openalex.org/W1995337883","https://openalex.org/W2009139525","https://openalex.org/W2016568386","https://openalex.org/W2021752975","https://openalex.org/W2023423199","https://openalex.org/W2023946729","https://openalex.org/W2026863172","https://openalex.org/W2028274300","https://openalex.org/W2036926586","https://openalex.org/W2041658447","https://openalex.org/W2048905477","https://openalex.org/W2049583947","https://openalex.org/W2056681493","https://openalex.org/W2060421431","https://openalex.org/W2084164012","https://openalex.org/W2112810120","https://openalex.org/W2122788299","https://openalex.org/W2129219291","https://openalex.org/W2131362842","https://openalex.org/W2138665045","https://openalex.org/W2148802069","https://openalex.org/W2155481621","https://openalex.org/W2159363679","https://openalex.org/W2161797998","https://openalex.org/W2163147844","https://openalex.org/W2164104132","https://openalex.org/W2257714798","https://openalex.org/W2319166137","https://openalex.org/W2327077232","https://openalex.org/W2411925036","https://openalex.org/W2418599318","https://openalex.org/W4230863386","https://openalex.org/W4253098556","https://openalex.org/W4298290178"],"related_works":["https://openalex.org/W2131183905","https://openalex.org/W2118309051","https://openalex.org/W2131362842","https://openalex.org/W2029580509","https://openalex.org/W2182921222","https://openalex.org/W787366628","https://openalex.org/W1590794385","https://openalex.org/W2254809110","https://openalex.org/W2000541314","https://openalex.org/W1967542596"],"abstract_inverted_index":{"To":[0],"understand":[1],"how":[2],"type":[3,45,223,247],"I":[4,46,224],"and":[5,33,40,47,61,152,169,183,225],"II":[6,48,226,248],"endometrial":[7,49,218],"tumors":[8,249],"uniquely":[9],"respond":[10,232],"to":[11,213,231,233],"tyrosine":[12],"kinase":[13,181],"inhibitor":[14],"treatments,":[15],"we":[16,127],"evaluated":[17],"the":[18,29,57,96,105,145,172,229,241,244,254],"signaling":[19,103,192,259],"pathways":[20,208],"of":[21,31,59,68,80,117,130,141,147,190,243,257],"epidermal":[22],"growth":[23,206],"factor":[24,207],"(EGF)":[25],"receptor":[26],"(EGFR)":[27],"under":[28],"effects":[30,158],"EGF":[32,167],"Iressa":[34,131,170,202],"(ZD1839,":[35],"gefitinib)":[36],"using":[37],"Ishikawa":[38,74,123,150],"H":[39,75,124,151],"Hec50co":[41,84,111,153,195],"cells":[42,53,76,85,112,154,196,220],"that":[43,110,197,204,217,221],"model":[44,222],"carcinomas,":[50],"respectively.":[51],"The":[52,186],"were":[54,198],"assayed":[55],"for":[56],"expression":[58],"EGFR":[60,70,148,174,234],"both":[62,134,164],"cell":[63,135,165],"lines":[64],"express":[65,77],"an":[66],"average":[67],"100,000":[69],"per":[71],"cell;":[72],"however,":[73,240],"higher":[78,115],"levels":[79],"HER-2/neu":[81],"compared":[82,89,121],"with":[83,90,122,155],"(1.38":[86],"x":[87,92],"10(5)":[88],"2.04":[91],"10(4),":[93],"respectively).":[94],"Using":[95],"Kinetworks":[97],"multi-immunoblotting":[98],"approach,":[99],"which":[100],"profiles":[101],"31":[102],"phosphoproteins,":[104],"most":[106],"striking":[107],"result":[108],"was":[109],"show":[113],"a":[114,139,237],"number":[116],"basal":[118,188],"phosphorylated":[119],"sites":[120],"cells.":[125],"Furthermore,":[126],"identified":[128],"targets":[129],"treatment":[132],"in":[133,149,163,194,211],"lines.":[136],"Iressa,":[137],"at":[138],"dose":[140],"1":[142,182],"micromol/L,":[143],"blocked":[144,171],"autophosphorylation":[146],"some":[156],"distinctive":[157],"on":[159],"downstream":[160],"effectors.":[161],"Nevertheless,":[162],"lines,":[166],"stimulated":[168],"major":[173],"target":[175],"mitogen-activated":[176],"protein":[177],"kinases":[178],"extracellular":[179],"signal-regulated":[180],"2":[184],"equally.":[185],"high":[187],"phosphorylation":[189],"numerous":[191],"molecules":[193],"not":[199],"inhibited":[200],"by":[201,253],"indicates":[203],"other":[205,258],"are":[209],"active":[210],"addition":[212],"EGFR.":[214],"We":[215],"conclude":[216],"cancer":[219],"carcinomas":[227],"have":[228],"capacity":[230],"inhibition":[235],"as":[236],"therapeutic":[238],"strategy;":[239],"response":[242],"more":[245],"aggressive":[246],"may":[250],"be":[251],"limited":[252],"constitutive":[255],"activation":[256],"pathways.":[260]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
