{"id":"https://openalex.org/W1986356355","doi":"https://doi.org/10.1016/j.biocel.2004.04.010","title":"Pathophysiology of chaperone-mediated autophagy","display_name":"Pathophysiology of chaperone-mediated autophagy","publication_year":2004,"publication_date":"2004-06-12","ids":{"openalex":"https://openalex.org/W1986356355","doi":"https://doi.org/10.1016/j.biocel.2004.04.010","mag":"1986356355","pmid":"https://pubmed.ncbi.nlm.nih.gov/15325582"},"language":"en","primary_location":{"id":"doi:10.1016/j.biocel.2004.04.010","doi":"https://doi.org/10.1016/j.biocel.2004.04.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2004.04.010","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry &amp; Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039174432","display_name":"Ashish C. Massey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Massey","raw_affiliation_strings":["Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087216602","display_name":"Roberta Kiffin","orcid":"https://orcid.org/0000-0002-4058-1327","observed_orcids":["https://orcid.org/0000-0002-4058-1327"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberta Kiffin","raw_affiliation_strings":["Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063410689","display_name":"Ana Mar\u00eda Cuervo","orcid":"https://orcid.org/0000-0002-0771-700X","observed_orcids":["https://orcid.org/0000-0002-0771-700X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Maria Cuervo","raw_affiliation_strings":["Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building Room 614, 1300 Morris Park Avenue, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063410689"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":1.4077,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.81008403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"36","issue":"12","first_page":"2420","last_page":"2434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chaperone-mediated-autophagy","display_name":"chaperone-mediated autophagy","score":1.0},{"id":"https://openalex.org/keywords/selective-protein-degradation","display_name":"selective protein degradation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6370000243186951},{"id":"https://openalex.org/keywords/disease-pathophysiology","display_name":"disease pathophysiology","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cytosolic-proteins","display_name":"cytosolic proteins","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8607993721961975},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.7043913006782532},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5413157939910889},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5051007866859436},{"id":"https://openalex.org/C141109615","wikidata":"https://www.wikidata.org/wiki/Q5137430","display_name":"Co-chaperone","level":5,"score":0.4634343087673187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42787501215934753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3401537537574768},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.2650512754917145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25552085041999817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22282710671424866},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.18972009420394897},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12121021747589111},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10171100497245789},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0903765857219696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08710801601409912}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016464","descriptor_name":"Lysosomal Storage Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biocel.2004.04.010","doi":"https://doi.org/10.1016/j.biocel.2004.04.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2004.04.010","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry &amp; Cell Biology","raw_type":"journal-article"},{"id":"pmid:15325582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15325582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of biochemistry & cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2541642547","display_name":"A mouse model for studying protein degradation in aging","funder_award_id":"R03AG019834","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G41368470","display_name":null,"funder_award_id":"AG19834","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5547241468","display_name":null,"funder_award_id":"AG-021904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320306158","display_name":"Huntington's Disease Society of America","ror":"https://ror.org/0064m4q05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W113469785","https://openalex.org/W149130878","https://openalex.org/W607885156","https://openalex.org/W1482715126","https://openalex.org/W1503849410","https://openalex.org/W1507759123","https://openalex.org/W1517182987","https://openalex.org/W1537517521","https://openalex.org/W1538904872","https://openalex.org/W1575488960","https://openalex.org/W1581683718","https://openalex.org/W1592870082","https://openalex.org/W1603142270","https://openalex.org/W1641175229","https://openalex.org/W1657935059","https://openalex.org/W1665138641","https://openalex.org/W1681758390","https://openalex.org/W1708445842","https://openalex.org/W1847698873","https://openalex.org/W1940885739","https://openalex.org/W1966233516","https://openalex.org/W1966347199","https://openalex.org/W1968322176","https://openalex.org/W1978791549","https://openalex.org/W1979647784","https://openalex.org/W1979931199","https://openalex.org/W1979940710","https://openalex.org/W1983075861","https://openalex.org/W1989821468","https://openalex.org/W1990992599","https://openalex.org/W1993205243","https://openalex.org/W1993772997","https://openalex.org/W1999797306","https://openalex.org/W2001087870","https://openalex.org/W2001467419","https://openalex.org/W2006665427","https://openalex.org/W2010247270","https://openalex.org/W2013389256","https://openalex.org/W2013944211","https://openalex.org/W2016066657","https://openalex.org/W2022964430","https://openalex.org/W2024589425","https://openalex.org/W2024656201","https://openalex.org/W2025933441","https://openalex.org/W2026589291","https://openalex.org/W2027263738","https://openalex.org/W2027589717","https://openalex.org/W2029098242","https://openalex.org/W2029235011","https://openalex.org/W2037213103","https://openalex.org/W2038684439","https://openalex.org/W2040007971","https://openalex.org/W2041687824","https://openalex.org/W2042141094","https://openalex.org/W2042356263","https://openalex.org/W2042496771","https://openalex.org/W2044479974","https://openalex.org/W2046520891","https://openalex.org/W2053394933","https://openalex.org/W2057491765","https://openalex.org/W2058035711","https://openalex.org/W2061136786","https://openalex.org/W2062790216","https://openalex.org/W2063403801","https://openalex.org/W2066727453","https://openalex.org/W2068954926","https://openalex.org/W2072310161","https://openalex.org/W2075428562","https://openalex.org/W2076414352","https://openalex.org/W2076825051","https://openalex.org/W2077685312","https://openalex.org/W2079182555","https://openalex.org/W2080666854","https://openalex.org/W2095208811","https://openalex.org/W2096794529","https://openalex.org/W2098561880","https://openalex.org/W2099301077","https://openalex.org/W2105637710","https://openalex.org/W2106043356","https://openalex.org/W2106733439","https://openalex.org/W2107770907","https://openalex.org/W2115864709","https://openalex.org/W2124165909","https://openalex.org/W2124325580","https://openalex.org/W2126943184","https://openalex.org/W2133538175","https://openalex.org/W2134892601","https://openalex.org/W2139609944","https://openalex.org/W2143358143","https://openalex.org/W2144687501","https://openalex.org/W2144789639","https://openalex.org/W2145968380","https://openalex.org/W2148396143","https://openalex.org/W2151974289","https://openalex.org/W2157053804","https://openalex.org/W2159007909","https://openalex.org/W2166272591","https://openalex.org/W2168445378","https://openalex.org/W2172223287","https://openalex.org/W2239066292","https://openalex.org/W2312805189","https://openalex.org/W2326959862","https://openalex.org/W2792139654","https://openalex.org/W4234505218","https://openalex.org/W4239776692"],"related_works":["https://openalex.org/W7220415847","https://openalex.org/W1487064198","https://openalex.org/W2021492060","https://openalex.org/W2152541437","https://openalex.org/W2795906582","https://openalex.org/W3147821081","https://openalex.org/W2009128541","https://openalex.org/W1964976537","https://openalex.org/W2476283992","https://openalex.org/W2404905481"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
