{"id":"https://openalex.org/W1986332014","doi":"https://doi.org/10.1074/jbc.273.23.14119","title":"Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I","display_name":"Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1986332014","doi":"https://doi.org/10.1074/jbc.273.23.14119","mag":"1986332014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9603911"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.23.14119","doi":"https://doi.org/10.1074/jbc.273.23.14119","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.23.14119","pdf_url":"http://www.jbc.org/article/S0021925819774444/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819774444/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113542939","display_name":"Kiyoshi Ohtani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Ohtani","raw_affiliation_strings":["Human Gene Sciences Center, Japan","Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Gene Sciences Center, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014770114","display_name":"Atsumi Tsujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsumi Tsujimoto","raw_affiliation_strings":["Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103736797","display_name":"Tomonori Tsukahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Tsukahara","raw_affiliation_strings":["Department of Immunotherapeutics, Medical Research Division, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunotherapeutics, Medical Research Division, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085732658","display_name":"Noboru Numata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256171","display_name":"Sendai City Institute of Public Health","ror":"https://ror.org/03vnpk711","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256171"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Numata","raw_affiliation_strings":["Department of Microbiology, Sendai Municipal Institute of Public Health, 2-5-10 Oroshimachi-higashi, Wakabayashi-ku, Sendai 983-0002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Sendai Municipal Institute of Public Health, 2-5-10 Oroshimachi-higashi, Wakabayashi-ku, Sendai 983-0002","institution_ids":["https://openalex.org/I4405256171"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeto Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Miura","raw_affiliation_strings":["Core Research for Evolutional Science and Technology, Japan Science and Technology Corp., 4-1-8 Honcho, Kawaguchi 332-0012, Japan","Department of Microbiology and Immunology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology, Japan Science and Technology Corp., 4-1-8 Honcho, Kawaguchi 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087838405","display_name":"Kazuo Sugamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Sugamura","raw_affiliation_strings":["Department of Microbiology and Immunology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035156230","display_name":"Masataka Nakamura","orcid":"https://orcid.org/0000-0002-0439-5682","observed_orcids":["https://orcid.org/0000-0002-0439-5682"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masataka Nakamura","raw_affiliation_strings":["Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035156230"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2896,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.79333422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"273","issue":"23","first_page":"14119","last_page":"14129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nf-kappab-binding","display_name":"NF-kappaB binding","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-family","display_name":"tumor necrosis factor family","score":0.7680000066757202},{"id":"https://openalex.org/keywords/core-promoter","display_name":"core promoter","score":0.41600000858306885},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6203370690345764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5764278769493103},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5736714005470276},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47520551085472107},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45065072178840637},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4093402326107025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36157363653182983},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3531438708305359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.277401864528656}],"mesh":[{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016356","descriptor_name":"Gene Products, tax","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.23.14119","doi":"https://doi.org/10.1074/jbc.273.23.14119","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.23.14119","pdf_url":"http://www.jbc.org/article/S0021925819774444/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9603911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9603911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.23.14119","doi":"https://doi.org/10.1074/jbc.273.23.14119","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.23.14119","pdf_url":"http://www.jbc.org/article/S0021925819774444/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322203","display_name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","ror":"https://ror.org/043s0fn12"},{"id":"https://openalex.org/F4320322210","display_name":"Inamori Foundation","ror":"https://ror.org/00ht8je70"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986332014.pdf","grobid_xml":"https://content.openalex.org/works/W1986332014.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W42043509","https://openalex.org/W63931606","https://openalex.org/W105127712","https://openalex.org/W179437740","https://openalex.org/W195679876","https://openalex.org/W1481259039","https://openalex.org/W1483636703","https://openalex.org/W1516457342","https://openalex.org/W1602037964","https://openalex.org/W1760665651","https://openalex.org/W1762550967","https://openalex.org/W1864024056","https://openalex.org/W1876315427","https://openalex.org/W1933156589","https://openalex.org/W1935210417","https://openalex.org/W1969033718","https://openalex.org/W1974428835","https://openalex.org/W1977348907","https://openalex.org/W1983795855","https://openalex.org/W1987438129","https://openalex.org/W1998461588","https://openalex.org/W2000090884","https://openalex.org/W2002507218","https://openalex.org/W2002601205","https://openalex.org/W2006552010","https://openalex.org/W2013063662","https://openalex.org/W2016534065","https://openalex.org/W2019698681","https://openalex.org/W2022627708","https://openalex.org/W2023262811","https://openalex.org/W2025959287","https://openalex.org/W2028368276","https://openalex.org/W2028809209","https://openalex.org/W2032496145","https://openalex.org/W2033447452","https://openalex.org/W2042043269","https://openalex.org/W2048022927","https://openalex.org/W2049496770","https://openalex.org/W2058350611","https://openalex.org/W2063480372","https://openalex.org/W2069667541","https://openalex.org/W2079473939","https://openalex.org/W2086143621","https://openalex.org/W2088261928","https://openalex.org/W2088493593","https://openalex.org/W2089559330","https://openalex.org/W2102572112","https://openalex.org/W2117716734","https://openalex.org/W2126217474","https://openalex.org/W2137140293","https://openalex.org/W2144206181","https://openalex.org/W2144766409","https://openalex.org/W2146419650","https://openalex.org/W2152922534","https://openalex.org/W2162039003","https://openalex.org/W2167813683","https://openalex.org/W2285257305","https://openalex.org/W2325363379","https://openalex.org/W2395185936","https://openalex.org/W2396260384","https://openalex.org/W2411741726","https://openalex.org/W2419184511","https://openalex.org/W2443038188"],"related_works":["https://openalex.org/W1969033718","https://openalex.org/W2152493100","https://openalex.org/W1817611974","https://openalex.org/W2024688294","https://openalex.org/W2117588280","https://openalex.org/W1544092207","https://openalex.org/W2024373861","https://openalex.org/W2043138452","https://openalex.org/W2413840417","https://openalex.org/W4245118440"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,9,13,34,57,66,93,124,130,149,159,178,187,191,219],"molecular":[3],"mechanism":[4],"of":[5,8,16,56,148,169,177,190,216,218,225,229],"transcriptional":[6,53],"activation":[7],"gp34":[10,25,58,75,163,220,226],"gene":[11,59,221],"by":[12,62,78,167],"Tax":[14,64],"oncoprotein":[15],"human":[17,67],"T":[18,50,68,232],"cell":[19,69],"leukemia":[20],"virus":[21],"type":[22,28],"I":[23],"(HTLV-I).":[24],"is":[26,40,76],"a":[27,110,208],"II":[29],"transmembrane":[30],"molecule":[31],"belonging":[32],"to":[33,101,103],"tumor":[35],"necrosis":[36],"factor":[37],"family":[38],"and":[39,88,203,222],"constitutively":[41],"expressed":[42],"on":[43],"HTLV-I-producing":[44],"cells":[45,171],"but":[46],"not":[47,165],"normal":[48],"resting":[49],"cells.":[51,233],"The":[52],"regulatory":[54,94],"region":[55,188,197],"was":[60,121,126],"activated":[61,166],"HTLV-I":[63,230],"in":[65,72,92,109,162,207,227],"line":[70],"Jurkat,":[71],"which":[73],"endogenous":[74],"induced":[77],"Tax.":[79],"Sequence":[80],"analysis":[81],"demonstrated":[82],"that":[83,117,129,198],"two":[84],"NF-kappaB-like":[85,97,118,133,142,160,179,192],"elements":[86,98,150,161,193],"(1":[87],"2)":[89],"were":[90,99,164],"present":[91],"region.":[95],"Both":[96],"able":[100],"bind":[102],"NF-kappaB":[104,157],"or":[105],"its":[106],"related":[107],"factor(s)":[108],"Tax-dependent":[111],"manner.":[112,210],"Chloramphenicol":[113,182],"acetyltransferase":[114,183],"assays":[115,185],"indicated":[116],"element":[119,134,143],"1":[120],"Tax-responsive,":[122],"although":[123],"activity":[125,138],"lower":[127],"than":[128],"native":[131],"promoter.":[132],"2":[135],"elevated":[136],"promoter":[137,153],"when":[139],"combined":[140],"with":[141,172],"1,":[144],"indicating":[145],"cooperative":[146],"function":[147],"for":[151],"maximum":[152],"function.":[154],"Unlike":[155],"typical":[156],"elements,":[158],"treatment":[168],"Jurkat":[170],"phorbol":[173],"ester":[174],"despite":[175],"induction":[176],"binding":[180],"activity.":[181],"reporter":[184],"using":[186],"upstream":[189,196],"identified":[194],"an":[195],"reduced":[199],"transcription":[200],"from":[201],"cognate":[202],"noncognate":[204],"core":[205],"promoters":[206],"Tax-independent":[209],"Our":[211],"results":[212],"imply":[213],"complex":[214],"regulation":[215],"expression":[217],"suggest":[223],"implication":[224],"proliferation":[228],"infected":[231]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}