{"id":"https://openalex.org/W1986320552","doi":"https://doi.org/10.1016/j.semcdb.2014.05.002","title":"G-protein-coupled receptors, Hedgehog signaling and primary cilia","display_name":"G-protein-coupled receptors, Hedgehog signaling and primary cilia","publication_year":2014,"publication_date":"2014-05-17","ids":{"openalex":"https://openalex.org/W1986320552","doi":"https://doi.org/10.1016/j.semcdb.2014.05.002","mag":"1986320552","pmid":"https://pubmed.ncbi.nlm.nih.gov/24845016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130902"},"language":"en","primary_location":{"id":"doi:10.1016/j.semcdb.2014.05.002","doi":"https://doi.org/10.1016/j.semcdb.2014.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2014.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell & Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024389946","display_name":"Saikat Mukhopadhyay","orcid":"https://orcid.org/0000-0003-4790-3090","observed_orcids":["https://orcid.org/0000-0003-4790-3090"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saikat Mukhopadhyay","raw_affiliation_strings":["Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: saikat.mukhopadhyay@utsouthwestern.edu","Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: saikat.mukhopadhyay@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055546235","display_name":"Rajat Rohatgi","orcid":"https://orcid.org/0000-0001-7609-8858","observed_orcids":["https://orcid.org/0000-0001-7609-8858"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajat Rohatgi","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA. Electronic address: rrohatgi@stanford.edu","Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA","Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA. Electronic address: rrohatgi@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024389946","https://openalex.org/A5055546235"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I867280407","https://openalex.org/I97018004"],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":1.5891,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.84556131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"33","issue":null,"first_page":"63","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.953000009059906},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/smoothened","display_name":"Smoothened","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gpr161","display_name":"GPR161","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C145837895","wikidata":"https://www.wikidata.org/wiki/Q18031607","display_name":"Smoothened","level":4,"score":0.9237464070320129},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.923022985458374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.893686056137085},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8560632467269897},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7694022059440613},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7086321115493774},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6605009436607361},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6297792792320251},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43685874342918396},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4118672311306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17444628477096558}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.semcdb.2014.05.002","doi":"https://doi.org/10.1016/j.semcdb.2014.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2014.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell & Developmental Biology","raw_type":"journal-article"},{"id":"pmid:24845016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24845016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cell & developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3526005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4130902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Cell Dev Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3526005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3033203094","display_name":"Signal Transduction by Oxysterols","funder_award_id":"R01GM106078","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3152335814","display_name":"Biochemical Mechanisms of Hedgehog Signaling","funder_award_id":"R00CA129174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6053938340","display_name":"Reconstructing Primary Cilia","funder_award_id":"DP2GM105448","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320308911","display_name":"Sontag Foundation","ror":"https://ror.org/01pkpj777"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":"https://ror.org/001d55x84"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W1481472040","https://openalex.org/W1543890504","https://openalex.org/W1580962701","https://openalex.org/W1722148928","https://openalex.org/W1959046600","https://openalex.org/W1963493384","https://openalex.org/W1963807253","https://openalex.org/W1966998932","https://openalex.org/W1971060771","https://openalex.org/W1974043427","https://openalex.org/W1974094726","https://openalex.org/W1976421227","https://openalex.org/W1979067492","https://openalex.org/W1981691061","https://openalex.org/W1983341583","https://openalex.org/W1985661051","https://openalex.org/W1986184460","https://openalex.org/W1987913532","https://openalex.org/W1988097700","https://openalex.org/W1991138299","https://openalex.org/W1993416164","https://openalex.org/W1993465232","https://openalex.org/W1995078993","https://openalex.org/W1995651171","https://openalex.org/W1997628120","https://openalex.org/W1999100324","https://openalex.org/W2001161463","https://openalex.org/W2001173847","https://openalex.org/W2002249795","https://openalex.org/W2007764395","https://openalex.org/W2011070056","https://openalex.org/W2012535690","https://openalex.org/W2012863615","https://openalex.org/W2015382764","https://openalex.org/W2015557754","https://openalex.org/W2016654953","https://openalex.org/W2017400416","https://openalex.org/W2021193175","https://openalex.org/W2022877314","https://openalex.org/W2023724239","https://openalex.org/W2026755963","https://openalex.org/W2027415486","https://openalex.org/W2029500889","https://openalex.org/W2032792789","https://openalex.org/W2036833206","https://openalex.org/W2040182956","https://openalex.org/W2040203747","https://openalex.org/W2040279612","https://openalex.org/W2043289157","https://openalex.org/W2044753677","https://openalex.org/W2048262130","https://openalex.org/W2049484225","https://openalex.org/W2049859215","https://openalex.org/W2051301625","https://openalex.org/W2053351302","https://openalex.org/W2053385369","https://openalex.org/W2059614045","https://openalex.org/W2061616166","https://openalex.org/W2061684132","https://openalex.org/W2063299495","https://openalex.org/W2063340261","https://openalex.org/W2066480724","https://openalex.org/W2066711817","https://openalex.org/W2068661995","https://openalex.org/W2070184849","https://openalex.org/W2070524647","https://openalex.org/W2071435286","https://openalex.org/W2071781502","https://openalex.org/W2072547641","https://openalex.org/W2072618030","https://openalex.org/W2072917759","https://openalex.org/W2073521369","https://openalex.org/W2074314807","https://openalex.org/W2075126779","https://openalex.org/W2075994912","https://openalex.org/W2078725182","https://openalex.org/W2083249373","https://openalex.org/W2083701433","https://openalex.org/W2083988049","https://openalex.org/W2085132889","https://openalex.org/W2085356690","https://openalex.org/W2085775776","https://openalex.org/W2090455515","https://openalex.org/W2091684557","https://openalex.org/W2094092533","https://openalex.org/W2094399319","https://openalex.org/W2095243783","https://openalex.org/W2095486148","https://openalex.org/W2097514247","https://openalex.org/W2099118069","https://openalex.org/W2099970745","https://openalex.org/W2100465045","https://openalex.org/W2102000129","https://openalex.org/W2103846588","https://openalex.org/W2104505841","https://openalex.org/W2105663489","https://openalex.org/W2109366400","https://openalex.org/W2109685426","https://openalex.org/W2110975457","https://openalex.org/W2111826622","https://openalex.org/W2112591804","https://openalex.org/W2114824375","https://openalex.org/W2114873132","https://openalex.org/W2119326753","https://openalex.org/W2121998739","https://openalex.org/W2122294512","https://openalex.org/W2123117059","https://openalex.org/W2124120257","https://openalex.org/W2126920991","https://openalex.org/W2127168458","https://openalex.org/W2127472285","https://openalex.org/W2127882408","https://openalex.org/W2128801071","https://openalex.org/W2131686724","https://openalex.org/W2131830004","https://openalex.org/W2135102992","https://openalex.org/W2136445329","https://openalex.org/W2136758573","https://openalex.org/W2137279272","https://openalex.org/W2137700247","https://openalex.org/W2138058987","https://openalex.org/W2140864413","https://openalex.org/W2141640690","https://openalex.org/W2142697077","https://openalex.org/W2144558833","https://openalex.org/W2145203496","https://openalex.org/W2145845789","https://openalex.org/W2149380656","https://openalex.org/W2152221138","https://openalex.org/W2153260902","https://openalex.org/W2155993944","https://openalex.org/W2157103346","https://openalex.org/W2159970646","https://openalex.org/W2162109316","https://openalex.org/W2162146057","https://openalex.org/W2163838718","https://openalex.org/W2167353494","https://openalex.org/W2168569886","https://openalex.org/W2170193319","https://openalex.org/W2339219645","https://openalex.org/W2474599166","https://openalex.org/W2617383873","https://openalex.org/W3150496065","https://openalex.org/W4211143281","https://openalex.org/W7073899588"],"related_works":["https://openalex.org/W3007243279","https://openalex.org/W4409807890","https://openalex.org/W2292239198","https://openalex.org/W2136002176","https://openalex.org/W7099322768","https://openalex.org/W2123441307","https://openalex.org/W2304485901","https://openalex.org/W4391630648","https://openalex.org/W7132950785","https://openalex.org/W2070184849"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}