{"id":"https://openalex.org/W1986320549","doi":"https://doi.org/10.1055/s-2008-1034320","title":"Magnolol and Honokiol Account for the Anti-Spasmodic Effect of Magnolia officinalis in Isolated Guinea Pig Ileum","display_name":"Magnolol and Honokiol Account for the Anti-Spasmodic Effect of Magnolia officinalis in Isolated Guinea Pig Ileum","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W1986320549","doi":"https://doi.org/10.1055/s-2008-1034320","mag":"1986320549","pmid":"https://pubmed.ncbi.nlm.nih.gov/18484527"},"language":"en","primary_location":{"id":"doi:10.1055/s-2008-1034320","doi":"https://doi.org/10.1055/s-2008-1034320","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1034320","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041716623","display_name":"Sunny Sun-Kin Chan","orcid":"https://orcid.org/0000-0003-1432-7381","observed_orcids":["https://orcid.org/0000-0003-1432-7381"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Sunny Chan","raw_affiliation_strings":["School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110673540","display_name":"Ming Yi Zhao","orcid":"https://orcid.org/0009-0003-8870-0529","observed_orcids":["https://orcid.org/0009-0003-8870-0529"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China","Chinese University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015198590","display_name":"Lixing Lao","orcid":"https://orcid.org/0000-0003-0198-9714","observed_orcids":["https://orcid.org/0000-0003-0198-9714"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lixing Lao","raw_affiliation_strings":["Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, USA","University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071719326","display_name":"Harry Fong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Fong","raw_affiliation_strings":["Program for the Collaborative Research in Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program for the Collaborative Research in Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083448314","display_name":"Chun\u2010Tao Che","orcid":"https://orcid.org/0000-0001-7064-271X","observed_orcids":["https://orcid.org/0000-0001-7064-271X"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chun-Tao Che","raw_affiliation_strings":["School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China","Chinese University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4942,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8688546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"74","issue":"4","first_page":"381","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnolia-officinalis","display_name":"Magnolia officinalis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/magnolol","display_name":"magnolol","score":1.0},{"id":"https://openalex.org/keywords/honokiol","display_name":"honokiol","score":1.0},{"id":"https://openalex.org/keywords/ileal-smooth-muscle-contraction","display_name":"ileal smooth muscle contraction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/acetylcholine-induced-contraction","display_name":"acetylcholine-induced contraction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.7979999780654907},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.7059999704360962},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gastrointestinal-diseases","display_name":"gastrointestinal diseases","score":0.6620000004768372},{"id":"https://openalex.org/keywords/phytochemical-constituents","display_name":"phytochemical constituents","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2781009524","wikidata":"https://www.wikidata.org/wiki/Q6732002","display_name":"Magnolol","level":2,"score":0.9955931901931763},{"id":"https://openalex.org/C2781334404","wikidata":"https://www.wikidata.org/wiki/Q5896650","display_name":"Honokiol","level":2,"score":0.9909665584564209},{"id":"https://openalex.org/C2780759288","wikidata":"https://www.wikidata.org/wiki/Q1042288","display_name":"Magnolia officinalis","level":4,"score":0.9023582339286804},{"id":"https://openalex.org/C2780886089","wikidata":"https://www.wikidata.org/wiki/Q7079617","display_name":"Officinalis","level":2,"score":0.63184654712677},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6159348487854004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5844469666481018},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5340486764907837},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5165594816207886},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.48023611307144165},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.46139809489250183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3217242658138275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3050578832626343},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.28352677822113037},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.22884532809257507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06034642457962036},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000498","descriptor_name":"Allyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031566","descriptor_name":"Magnolia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2008-1034320","doi":"https://doi.org/10.1055/s-2008-1034320","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1034320","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:18484527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18484527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/188598","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/188598","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2214159324","display_name":"Functional Bowel Disorders in Chinese Medicine","funder_award_id":"U19AT003266","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075563772","https://openalex.org/W2380151578","https://openalex.org/W3196217462","https://openalex.org/W2372263856","https://openalex.org/W1491256154","https://openalex.org/W2349977209","https://openalex.org/W2321198788","https://openalex.org/W1994916345","https://openalex.org/W2904053332","https://openalex.org/W2905333253"],"abstract_inverted_index":{"Magnolia":[0],"officinalis":[1,28,173],"is":[2],"a":[3,143],"commonly":[4],"used":[5],"traditional":[6],"Chinese":[7],"medicine":[8],"for":[9,167],"treating":[10],"gastrointestinal":[11],"disorders.":[12],"HPLC":[13],"quantification":[14],"analysis":[15],"revealed":[16],"that":[17,112,160],"magnolol":[18,59,105,117,149,162],"and":[19,45,60,106,118,129,150,163],"honokiol":[20,61,107,119,151,164],"were":[21,98],"the":[22,34,38,40,43,46,95,101,127,161,168],"most":[23],"abundant":[24],"constituents":[25],"of":[26,76,135,148,171],"M.":[27,172],"extracts,":[29],"with":[30],"their":[31,104,139],"contents":[32,165],"in":[33,51,73,91,103,126,175],"ethanol":[35,49,79,84,128,145],"extract":[36,42,50,80,85,146],"being":[37],"highest,":[39],"water":[41,87,130],"least":[44],"50":[47,82],"%":[48,83],"between.":[52],"In":[53],"guinea":[54,176],"pig":[55,177],"isolated":[56,178],"ileum,":[57],"both":[58],"inhibited":[62],"contraction":[63],"to":[64,100,123,153],"acetylcholine.":[65],"The":[66,89],"herbal":[67],"extracts":[68,97,131,141,174],"also":[69],"produced":[70],"inhibitory":[71,92],"responses,":[72],"an":[74],"order":[75],"decreasing":[77],"efficacy:":[78],">":[81,86],"extract.":[88],"differences":[90,102],"efficacies":[93],"among":[94],"three":[96],"similar":[99,133],"contents.":[108],"Further":[109],"examination":[110],"demonstrated":[111],"two":[113],"mixtures":[114],"containing":[115],"solely":[116],"at":[120],"concentrations":[121],"identical":[122],"those":[124],"determined":[125],"exhibited":[132],"levels":[134],"anti-spasmodic":[136,169],"effects":[137,170],"as":[138],"respective":[140],"while":[142],"\"blank\"":[144],"free":[147],"failed":[152],"produce":[154],"any":[155],"response.":[156],"These":[157],"observations":[158],"suggest":[159],"account":[166],"ileum.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}