{"id":"https://openalex.org/W1986308371","doi":"https://doi.org/10.2459/jcm.0b013e328332e926","title":"Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation: a meta-analysis of randomized trials","display_name":"Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation: a meta-analysis of randomized trials","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W1986308371","doi":"https://doi.org/10.2459/jcm.0b013e328332e926","mag":"1986308371","pmid":"https://pubmed.ncbi.nlm.nih.gov/19834326"},"language":"en","primary_location":{"id":"doi:10.2459/jcm.0b013e328332e926","doi":"https://doi.org/10.2459/jcm.0b013e328332e926","is_oa":false,"landing_page_url":"https://doi.org/10.2459/jcm.0b013e328332e926","pdf_url":null,"source":{"id":"https://openalex.org/S90613825","display_name":"Journal of Cardiovascular Medicine","issn_l":"1558-2027","issn":["1558-2027","1558-2035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001239142","display_name":"Carlo Bonanno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carlo Bonanno","raw_affiliation_strings":["Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy. cbonanno64@yahoo.it <cbonanno64@yahoo.it>","Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","e-mail: [email\u00a0protected]","fax: +39 0444 75 3250","to Dr Carlo Bonanno, Electrophysiology Unit, S. Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy Tel: +39 0444 75 3644"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy. cbonanno64@yahoo.it <cbonanno64@yahoo.it>","institution_ids":["https://openalex.org/I4210152245"]},{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +39 0444 75 3250","institution_ids":[]},{"raw_affiliation_string":"to Dr Carlo Bonanno, Electrophysiology Unit, S. Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy Tel: +39 0444 75 3644","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062547618","display_name":"Mariemma Paccanaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariemma Paccanaro","raw_affiliation_strings":["Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110613174","display_name":"Luigi La Vecchia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi La Vecchia","raw_affiliation_strings":["Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064742624","display_name":"RENATO OMETTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Ometto","raw_affiliation_strings":["Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019735083","display_name":"Alessandro Fontanelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Fontanelli","raw_affiliation_strings":["Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, S. Bortolo Hospital, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001239142"],"corresponding_institution_ids":["https://openalex.org/I4210152245"],"apc_list":null,"apc_paid":null,"fwci":1.5177,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.82296267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"408","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/radiofrequency-catheter-ablation","display_name":"radiofrequency catheter ablation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atrial-tachyarrhythmia-recurrence","display_name":"atrial tachyarrhythmia recurrence","score":0.9169999957084656},{"id":"https://openalex.org/keywords/atrial-flutter","display_name":"atrial flutter","score":0.7379999756813049},{"id":"https://openalex.org/keywords/atrial-tachycardia","display_name":"atrial tachycardia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/procedural-complications","display_name":"procedural complications","score":0.7950000166893005},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.941213846206665},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8649221658706665},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6544454097747803},{"id":"https://openalex.org/C2778292772","wikidata":"https://www.wikidata.org/wiki/Q1506572","display_name":"Atrial flutter","level":3,"score":0.6482419967651367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6335592865943909},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.6297209858894348},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6282675266265869},{"id":"https://openalex.org/C2779422446","wikidata":"https://www.wikidata.org/wiki/Q3513641","display_name":"Atrial tachycardia","level":4,"score":0.6196746826171875},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6117283701896667},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5804005861282349},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5332813858985901},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4924126863479614},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.4122842848300934},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36664313077926636}],"mesh":[{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2459/jcm.0b013e328332e926","doi":"https://doi.org/10.2459/jcm.0b013e328332e926","is_oa":false,"landing_page_url":"https://doi.org/10.2459/jcm.0b013e328332e926","pdf_url":null,"source":{"id":"https://openalex.org/S90613825","display_name":"Journal of Cardiovascular Medicine","issn_l":"1558-2027","issn":["1558-2027","1558-2035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:19834326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19834326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular medicine (Hagerstown, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W127402029","https://openalex.org/W1207268963","https://openalex.org/W1986215651","https://openalex.org/W1991784373","https://openalex.org/W2020741490","https://openalex.org/W2020777521","https://openalex.org/W2040377044","https://openalex.org/W2041743622","https://openalex.org/W2070249947","https://openalex.org/W2100922457","https://openalex.org/W2105908026","https://openalex.org/W2108743535","https://openalex.org/W2115580917","https://openalex.org/W2133730204","https://openalex.org/W2154269490","https://openalex.org/W2163947034","https://openalex.org/W2172245650","https://openalex.org/W2204712598","https://openalex.org/W2602663396"],"related_works":["https://openalex.org/W2114201079","https://openalex.org/W2763414476","https://openalex.org/W7162856959","https://openalex.org/W2154241671","https://openalex.org/W4221074301","https://openalex.org/W2097321917","https://openalex.org/W4386247889","https://openalex.org/W2940481076","https://openalex.org/W2020777521","https://openalex.org/W2020741490"],"abstract_inverted_index":{"BACKGROUND:":[0],"Atrial":[1],"fibrillation":[2,47],"is":[3,13,49,255],"the":[4,19,35,85,90,115,141,144,179,189,225,230,268,284,291],"most":[5],"common":[6],"arrhythmia":[7],"in":[8,34,76,96,178,188,224],"clinical":[9],"practice.":[10],"Its":[11],"treatment":[12,180],"still":[14],"widely":[15],"debated":[16],"due":[17],"to":[18,44,83,262,282],"large":[20],"variety":[21],"of":[22,65,94,117,121,135,143,164,175,185,270,288,293],"therapeutic":[23],"options.":[24],"Radiofrequency":[25],"catheter":[26],"ablation":[27,226,275],"(RFCA)":[28],"around":[29],"pulmonary":[30],"vein":[31],"ostia":[32],"and":[33,48,71,92,130,133,137,153,182,219,259,286],"left":[36],"atrium":[37],"has":[38],"been":[39,68],"proposed":[40],"as":[41,150],"a":[42,81,256],"technique":[43],"cure":[45,263],"atrial":[46,99,118,123,126,128,131,193,198,252,264,294],"now":[50],"performed":[51],"with":[52,98,111,213,229,243,251],"increasing":[53],"success":[54],"worldwide.":[55],"However,":[56],"few":[57],"randomized":[58],"controlled":[59],"trials":[60],"(RCTs)":[61],"are":[62,72,148,280],"available.":[63],"Some":[64],"these":[66],"have":[67],"published":[69],"recently":[70],"not":[73],"yet":[74],"included":[75],"meta-analyses.":[77],"OBJECTIVES:":[78],"We":[79,102],"conducted":[80],"meta-analysis":[82],"summarize":[84],"current":[86],"evidence":[87],"base":[88],"for":[89,106,114,290],"efficacy":[91,285],"safety":[93,287],"RFCA":[95,110,196,254,289],"patients":[97,177,187,250],"fibrillation.":[100,119,265,295],"METHODS:":[101],"searched":[103],"electronic":[104],"databases":[105],"relevant":[107],"RCTs":[108,166,279],"comparing":[109],"antiarrhythmic":[112],"drugs":[113],"management":[116,292],"Recurrence":[120],"any":[122],"tachyarrhythmia":[124,194,199],"(including":[125],"fibrillation,":[127,253],"flutter":[129],"tachycardia)":[132],"rate":[134],"complications":[136,218],"adverse":[138,220],"events":[139,221],"were":[140,167,222],"end-points":[142],"analysis.":[145],"The":[146],"results":[147,269],"reported":[149,223],"relative":[151],"risk":[152,204,234],"95%":[154,206,236],"confidence":[155,207,237],"interval,":[156],"calculated":[157],"using":[158],"RevMan":[159],"5.":[160],"RESULTS:":[161],"A":[162],"total":[163],"eight":[165],"identified":[168],"including":[169],"844":[170],"patients.":[171],"Overall,":[172],"98":[173],"(23.2%)":[174],"421":[176],"group":[181,191,227,232],"324":[183],"(76.6%)":[184],"423":[186],"control":[190,231],"had":[192],"recurrence.":[195],"decreased":[197],"recurrence":[200],"by":[201],"71%":[202],"(relative":[203,233],"0.29,":[205],"interval":[208,238],"0.20-0.41,":[209],"P":[210,240],"<":[211],"0.00001,":[212],"random":[214,244],"effects":[215,245],"model).":[216,246],"Fewer":[217],"compared":[228],"0.72,":[235],"0.40-1.30,":[239],"=":[241],"0.28,":[242],"CONCLUSION:":[247],"In":[248],"selected":[249],"relatively":[257],"effective":[258],"well-tolerated":[260],"procedure":[261],"Even":[266],"though":[267],"our":[271],"systematic":[272],"review":[273],"favour":[274],"therapy,":[276],"large,":[277],"well-designed":[278],"needed":[281],"confirm":[283]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}