{"id":"https://openalex.org/W1986297885","doi":"https://doi.org/10.1126/scitranslmed.3004140","title":"Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis","display_name":"Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W1986297885","doi":"https://doi.org/10.1126/scitranslmed.3004140","mag":"1986297885","pmid":"https://pubmed.ncbi.nlm.nih.gov/22855463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3846177"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.3004140","doi":"https://doi.org/10.1126/scitranslmed.3004140","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3004140","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3846177","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087291985","display_name":"Justin S. A. Perry","orcid":"https://orcid.org/0000-0003-4063-6524","observed_orcids":["https://orcid.org/0000-0003-4063-6524"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin S. A. Perry","raw_affiliation_strings":["Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072889309","display_name":"Sungpil Han","orcid":"https://orcid.org/0000-0002-4674-7682","observed_orcids":["https://orcid.org/0000-0002-4674-7682"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sungpil Han","raw_affiliation_strings":["Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","School of Medicine, Pusan National University, Yangsan 626870, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"School of Medicine, Pusan National University, Yangsan 626870, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020778111","display_name":"Quangang Xu","orcid":"https://orcid.org/0000-0002-4507-1377","observed_orcids":["https://orcid.org/0000-0002-4507-1377"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Quangang Xu","raw_affiliation_strings":["Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China","Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002151766","display_name":"Matthew L. Herman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Herman","raw_affiliation_strings":["Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043305392","display_name":"Lucy Boyce Kennedy","orcid":"https://orcid.org/0000-0001-6644-8922","observed_orcids":["https://orcid.org/0000-0001-6644-8922"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy B. Kennedy","raw_affiliation_strings":["Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyorgy Csako","raw_affiliation_strings":["Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080215421","display_name":"Bibiana Bielekova","orcid":"https://orcid.org/0000-0002-0959-9430","observed_orcids":["https://orcid.org/0000-0002-0959-9430"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibiana Bielekova","raw_affiliation_strings":["Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.8208,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.98855256,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"4","issue":"145","first_page":"145ra106","last_page":"145ra106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.906000018119812},{"id":"https://openalex.org/keywords/daclizumab","display_name":"daclizumab","score":0.9589999914169312},{"id":"https://openalex.org/keywords/il-2-receptor-alpha","display_name":"IL-2 receptor alpha","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lymphoid-tissue-inducer-cells","display_name":"lymphoid tissue inducer cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/innate-lymphoid-cells","display_name":"innate lymphoid cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.6520000100135803},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/intrathecal-inflammation","display_name":"intrathecal inflammation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cxcl13","display_name":"CXCL13","score":0.8009999990463257},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2779719350","wikidata":"https://www.wikidata.org/wiki/Q412920","display_name":"Daclizumab","level":4,"score":0.848448634147644},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.8382844924926758},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7699031829833984},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7443826198577881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6222575902938843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5147552490234375},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.48568353056907654},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.4361934959888458},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4297887980937958},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38783615827560425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21693742275238037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2156653106212616},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1580274999141693},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.15570029616355896},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14703187346458435},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.11172047257423401}],"mesh":[{"descriptor_ui":"D000077561","descriptor_name":"Daclizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054382","descriptor_name":"Chemokine CXCL13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1126/scitranslmed.3004140","doi":"https://doi.org/10.1126/scitranslmed.3004140","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3004140","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:22855463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22855463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2834632","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3846177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3846177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3846177","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2834632","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3846177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2112346536","display_name":"Comprehensive multimodal analysis of patients with neuroimmunological diseases","funder_award_id":"ZIANS003055","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4988861893","display_name":null,"funder_award_id":"Z99 NS999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6618758383","display_name":"From therapeutic mechanisms to unraveling the pathophysiology of MS","funder_award_id":"ZIANS003056","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1572316274","https://openalex.org/W1579102917","https://openalex.org/W1675927014","https://openalex.org/W1697418081","https://openalex.org/W1838558565","https://openalex.org/W1972442533","https://openalex.org/W1972650611","https://openalex.org/W1975389005","https://openalex.org/W1979408872","https://openalex.org/W1982840915","https://openalex.org/W1990879242","https://openalex.org/W1996481500","https://openalex.org/W1999795586","https://openalex.org/W2002011103","https://openalex.org/W2003687800","https://openalex.org/W2008403719","https://openalex.org/W2009570912","https://openalex.org/W2014437975","https://openalex.org/W2018505426","https://openalex.org/W2029529774","https://openalex.org/W2045376030","https://openalex.org/W2046637170","https://openalex.org/W2050571399","https://openalex.org/W2051905973","https://openalex.org/W2077107481","https://openalex.org/W2083837388","https://openalex.org/W2088094253","https://openalex.org/W2092024887","https://openalex.org/W2099761180","https://openalex.org/W2101190412","https://openalex.org/W2101684276","https://openalex.org/W2102369421","https://openalex.org/W2109265527","https://openalex.org/W2113485611","https://openalex.org/W2113754168","https://openalex.org/W2113987403","https://openalex.org/W2114942536","https://openalex.org/W2118818657","https://openalex.org/W2119532085","https://openalex.org/W2121931605","https://openalex.org/W2129134090","https://openalex.org/W2129235766","https://openalex.org/W2130974415","https://openalex.org/W2132130088","https://openalex.org/W2154328223","https://openalex.org/W2162449424","https://openalex.org/W2163209710","https://openalex.org/W2164351607"],"related_works":["https://openalex.org/W2802487940","https://openalex.org/W2016046171","https://openalex.org/W2112079575","https://openalex.org/W2072114707","https://openalex.org/W2619034317","https://openalex.org/W2030203035","https://openalex.org/W2952775560","https://openalex.org/W2154468886","https://openalex.org/W2921992800","https://openalex.org/W2140848986"],"abstract_inverted_index":{"Genetic":[0],"polymorphisms":[1],"in":[2,82,166,201,211],"the":[3,26,172,202],"interleukin-2":[4],"receptor":[5,67],"\u03b1":[6],"(IL-2R\u03b1)":[7],"chain":[8],"(CD25)":[9],"locus":[10],"are":[11,199],"associated":[12],"with":[13],"several":[14],"human":[15,212],"autoimmune":[16],"diseases,":[17],"including":[18,218],"multiple":[19],"sclerosis":[20],"(MS).":[21],"Blockade":[22],"of":[23,51,61,96,122,185,204],"CD25":[24],"by":[25,170,191],"humanized":[27],"monoclonal":[28],"antibody":[29],"daclizumab":[30,52,119,192],"decreases":[31],"MS-associated":[32],"inflammation":[33,165],"but":[34,98],"has":[35],"surprisingly":[36],"limited":[37],"direct":[38],"inhibitory":[39],"effects":[40,50],"on":[41,54],"activated":[42],"T":[43],"cells.":[44],"The":[45,59],"present":[46],"study":[47,195],"describes":[48],"unexpected":[49],"therapy":[53,91],"innate":[55],"lymphoid":[56,72,153],"cells":[57,106,124,129,141,150],"(ILCs).":[58],"number":[60],"circulating":[62],"retinoic":[63],"acid":[64],"receptor-related":[65],"orphan":[66],"\u03b3t-positive":[68],"ILCs,":[69],"which":[70],"include":[71],"tissue":[73],"inducer":[74],"(LTi)":[75],"cells,":[76],"was":[77],"found":[78],"to":[79,87],"be":[80,215],"elevated":[81],"untreated":[83],"MS":[84,168],"patients":[85,169],"compared":[86],"healthy":[88],"subjects.":[89],"Daclizumab":[90],"not":[92],"only":[93],"decreased":[94],"numbers":[95],"ILCs":[97,132,198],"also":[99],"modified":[100],"their":[101,135,209,219],"phenotype":[102],"away":[103],"from":[104,125],"LTi":[105,123,149],"and":[107,180,208],"toward":[108,137],"a":[109],"natural":[110],"killer":[111],"(NK)":[112],"cell":[113],"lineage.":[114],"Mechanistic":[115],"studies":[116],"indicated":[117],"that":[118,197],"inhibited":[120,190],"differentiation":[121,136],"CD34\u207a":[126],"hematopoietic":[127],"progenitor":[128],"or":[130,156],"c-kit\u207a":[131],"indirectly,":[133],"steering":[134],"immunoregulatory":[138],"CD56(bright)":[139],"NK":[140],"through":[142],"enhanced":[143],"intermediate-affinity":[144],"IL-2":[145],"signaling.":[146],"Because":[147],"adult":[148],"may":[151],"retain":[152],"tissue-inducing":[154],"capacity":[155],"stimulate":[157],"adaptive":[158,205],"immune":[159,206],"responses,":[160,207],"we":[161],"indirectly":[162],"measured":[163],"intrathecal":[164],"daclizumab-treated":[167],"quantifying":[171],"cerebrospinal":[173],"fluid":[174],"chemokine":[175],"(C-X-C":[176],"motif)":[177],"ligand":[178],"13":[179],"immunoglobulin":[181],"G":[182],"index.":[183],"Both":[184],"these":[186],"inflammatory":[187],"biomarkers":[188],"were":[189],"treatment.":[193],"Our":[194],"indicates":[196],"involved":[200],"regulation":[203],"role":[210],"autoimmunity":[213],"should":[214],"investigated":[216],"further,":[217],"potential":[220],"as":[221],"therapeutic":[222],"targets.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}