{"id":"https://openalex.org/W1986259688","doi":"https://doi.org/10.1182/blood-2006-03-013789","title":"Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils","display_name":"Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils","publication_year":2006,"publication_date":"2006-08-25","ids":{"openalex":"https://openalex.org/W1986259688","doi":"https://doi.org/10.1182/blood-2006-03-013789","mag":"1986259688","pmid":"https://pubmed.ncbi.nlm.nih.gov/16931627"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2006-03-013789","doi":"https://doi.org/10.1182/blood-2006-03-013789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2006-03-013789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045969851","display_name":"Kathleen Szczur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Szczur","raw_affiliation_strings":["From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662441","display_name":"Haiming Xu","orcid":"https://orcid.org/0000-0003-1137-756X","observed_orcids":["https://orcid.org/0000-0003-1137-756X"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiming Xu","raw_affiliation_strings":["From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037887246","display_name":"Simon J. Atkinson","orcid":"https://orcid.org/0000-0002-7557-1532","observed_orcids":["https://orcid.org/0000-0002-7557-1532"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Atkinson","raw_affiliation_strings":["From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020584779","display_name":"Yi Zheng","orcid":"https://orcid.org/0000-0001-7089-6074","observed_orcids":["https://orcid.org/0000-0001-7089-6074"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zheng","raw_affiliation_strings":["From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057841502","display_name":"Marie\u2013Dominique Filippi","orcid":"https://orcid.org/0000-0002-7808-0237","observed_orcids":["https://orcid.org/0000-0002-7808-0237"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-Dominique Filippi","raw_affiliation_strings":["From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Experimental Hematology, Cincinnati Children's Research Foundation, University Cincinnati College of Medicine, OH; and Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.5816,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.88953264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"108","issue":"13","first_page":"4205","last_page":"4213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.8539999723434448},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-directionality","display_name":"cell directionality","score":0.7409999966621399},{"id":"https://openalex.org/keywords/random-motility","display_name":"random motility","score":0.6570000052452087},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/filopodia","display_name":"filopodia","score":0.921999990940094},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.7120000123977661},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.6330000162124634},{"id":"https://openalex.org/keywords/neutrophil-transmigration","display_name":"neutrophil transmigration","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.8854981660842896},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.8367922306060791},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8250810503959656},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.7901698350906372},{"id":"https://openalex.org/C90301020","wikidata":"https://www.wikidata.org/wiki/Q14859810","display_name":"Filopodia","level":3,"score":0.7068082094192505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5153753161430359},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.5045441389083862},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.502549409866333},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.45981794595718384},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.45903706550598145},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.45214492082595825},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4481661021709442},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43512994050979614},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3989764451980591},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.3497750163078308},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18273094296455383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13028699159622192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2006-03-013789","doi":"https://doi.org/10.1182/blood-2006-03-013789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2006-03-013789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:16931627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16931627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/4188","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/4188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/4188","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/4188","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306571","display_name":"American Society of Hematology","ror":"https://ror.org/02nw48b86"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W116666732","https://openalex.org/W1527082449","https://openalex.org/W1560364786","https://openalex.org/W1598659248","https://openalex.org/W1606615500","https://openalex.org/W1902258932","https://openalex.org/W1948361600","https://openalex.org/W1974514343","https://openalex.org/W1974896636","https://openalex.org/W1979346765","https://openalex.org/W1983447167","https://openalex.org/W1986013003","https://openalex.org/W1989343487","https://openalex.org/W1989550450","https://openalex.org/W1997089381","https://openalex.org/W1998670692","https://openalex.org/W2000824711","https://openalex.org/W2005216911","https://openalex.org/W2007660746","https://openalex.org/W2009718333","https://openalex.org/W2010630254","https://openalex.org/W2012089318","https://openalex.org/W2015458324","https://openalex.org/W2022827874","https://openalex.org/W2022991180","https://openalex.org/W2029393050","https://openalex.org/W2040196938","https://openalex.org/W2043420241","https://openalex.org/W2048148938","https://openalex.org/W2048209624","https://openalex.org/W2062852486","https://openalex.org/W2063220206","https://openalex.org/W2066139399","https://openalex.org/W2066723778","https://openalex.org/W2075210551","https://openalex.org/W2076064948","https://openalex.org/W2077834462","https://openalex.org/W2078384542","https://openalex.org/W2081758202","https://openalex.org/W2085761963","https://openalex.org/W2086884747","https://openalex.org/W2093226717","https://openalex.org/W2105927378","https://openalex.org/W2107057858","https://openalex.org/W2110007722","https://openalex.org/W2114319115","https://openalex.org/W2123305987","https://openalex.org/W2130711943","https://openalex.org/W2132593826","https://openalex.org/W2133891056","https://openalex.org/W2141042173","https://openalex.org/W2142214654","https://openalex.org/W2144905672","https://openalex.org/W2146133428","https://openalex.org/W2146981926","https://openalex.org/W2153482320","https://openalex.org/W2160154454","https://openalex.org/W2164396922","https://openalex.org/W2170770186","https://openalex.org/W2582398023","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4302362910","https://openalex.org/W4238268944","https://openalex.org/W3163476037","https://openalex.org/W2384069937","https://openalex.org/W2415847215","https://openalex.org/W2089107258","https://openalex.org/W2970208461","https://openalex.org/W171938471","https://openalex.org/W2803122114","https://openalex.org/W2470287322"],"abstract_inverted_index":{"Neutrophil":[0],"transmigration":[1],"into":[2],"tissue":[3],"is":[4],"a":[5,11],"multiple-step":[6],"process":[7],"that":[8,56,108,141],"results":[9],"from":[10],"coordinated":[12],"rearrangement":[13],"of":[14,23],"the":[15,39,47,79,122],"cytoskeleton":[16],"and":[17,21,25,33,63,97,101,147],"adhesion":[18,26],"complexes.":[19],"Assembly":[20],"disassembly":[22],"actin":[24],"structures":[27,76,120],"dictate":[28],"motility":[29,62,116,146],"behavior,":[30],"while":[31,70,126],"polarity":[32],"gradient":[34],"sensing":[35],"provide":[36],"directionality":[37,148],"to":[38],"cell":[40,123],"movement.":[41],"Here,":[42],"using":[43],"mice":[44],"deficient":[45],"in":[46,82,88,149],"CDC42":[48,50,57,142],"regulator":[49],"GTPase-activating":[51],"protein":[52,155],"(CDC42GAP),":[53],"we":[54],"demonstrate":[55],"activity":[58,114,143],"separately":[59],"regulates":[60,115,130,144],"neutrophil":[61],"directionality.":[64],"CDC42GAP-/-":[65,89,91],"neutrophils":[66,84,92],"showed":[67,94],"increased":[68,95],"motility,":[69],"directed":[71,131],"migration":[72,132],"was":[73],"defective.":[74],"Podosome-like":[75],"present":[77],"at":[78,121],"leading":[80,124],"edge":[81],"wild-type":[83],"were":[85],"significantly":[86],"reduced":[87],"cells.":[90],"also":[93],"lateral":[96],"tail":[98],"filopodia-like":[99],"formation,":[100],"excess":[102],"membrane":[103],"protrusions.":[104],"We":[105],"further":[106],"suggest":[107],"CDC42GAP-mediated":[109],"extracellular":[110],"signal-regulated":[111],"kinase":[112,156],"(ERK)":[113],"associated":[117],"with":[118],"podosome-like":[119],"edge,":[125],"CDC42GAP-induced":[127],"p38(MAPK)":[128],"phosphorylation":[129],"by":[133],"antagonizing":[134],"filopodia":[135],"assembly.":[136],"Overall,":[137],"this":[138],"study":[139],"reveals":[140],"both":[145],"neutrophils,":[150],"but":[151],"via":[152],"distinct":[153],"mitogen-activated":[154],"(MAPK)":[157],"pathways.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}