{"id":"https://openalex.org/W1986249584","doi":"https://doi.org/10.1016/s0304-3940(02)00586-4","title":"Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease","display_name":"Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1986249584","doi":"https://doi.org/10.1016/s0304-3940(02)00586-4","mag":"1986249584","pmid":"https://pubmed.ncbi.nlm.nih.gov/12161276"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3940(02)00586-4","doi":"https://doi.org/10.1016/s0304-3940(02)00586-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3940(02)00586-4","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000134866","display_name":"Mekki Boussaha","orcid":"https://orcid.org/0000-0002-5432-4604","observed_orcids":["https://orcid.org/0000-0002-5432-4604"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mekki Boussaha","raw_affiliation_strings":["INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077897163","display_name":"Didier Hannequin","orcid":"https://orcid.org/0000-0003-2662-0999","observed_orcids":["https://orcid.org/0000-0003-2662-0999"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Hannequin","raw_affiliation_strings":["INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026020623","display_name":"Patrice Verpillat","orcid":"https://orcid.org/0000-0003-0010-1699","observed_orcids":["https://orcid.org/0000-0003-0010-1699"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Verpillat","raw_affiliation_strings":["Inserm U 535, 94276 Le Kremlin Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 535, 94276 Le Kremlin Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027489586","display_name":"Alexis Brice","orcid":"https://orcid.org/0000-0002-0941-3990","observed_orcids":["https://orcid.org/0000-0002-0941-3990"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexis Brice","raw_affiliation_strings":["Inserm U 289, Hopital de la Salp\u00e9tri\u00e8re, 75013 Paris, France","INSERM U 289, H\u00f4pital de la Salp\u00e9tri\u00e8re, 75013 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U 289, Hopital de la Salp\u00e9tri\u00e8re, 75013 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405275326"]},{"raw_affiliation_string":"INSERM U 289, H\u00f4pital de la Salp\u00e9tri\u00e8re, 75013 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705","https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021709517","display_name":"Thierry Fr\u00e9bourg","orcid":"https://orcid.org/0000-0003-0399-4007","observed_orcids":["https://orcid.org/0000-0003-0399-4007"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Frebourg","raw_affiliation_strings":["INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107927035","display_name":"Dominique Campion","orcid":"https://orcid.org/0000-0003-1916-7890","observed_orcids":["https://orcid.org/0000-0003-1916-7890"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Dominique Campion","raw_affiliation_strings":["INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM EMI 9906, IFRMP, Facult\u00e9 de M\u00e9decine et de Pharmacie, 76183 Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5107927035"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":7.1802,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.97364608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"329","issue":"1","first_page":"121","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degrading-enzyme","display_name":"insulin-degrading enzyme","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9229999780654907},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.859000027179718},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.8090000152587891},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.7590000033378601},{"id":"https://openalex.org/keywords/case-control-association-studies","display_name":"case-control association","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7870047092437744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6792046427726746},{"id":"https://openalex.org/C2780331951","wikidata":"https://www.wikidata.org/wiki/Q1225690","display_name":"Insulin-degrading enzyme","level":3,"score":0.6701286435127258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6686723828315735},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6285536885261536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5690892338752747},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5625574588775635},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5501450300216675},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.490878164768219},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4871375262737274},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4339568614959717},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.34021860361099243},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3130010962486267},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21827435493469238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17239299416542053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15906742215156555}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007339","descriptor_name":"Insulysin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-3940(02)00586-4","doi":"https://doi.org/10.1016/s0304-3940(02)00586-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3940(02)00586-4","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:12161276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12161276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W172293654","https://openalex.org/W267021110","https://openalex.org/W1964727739","https://openalex.org/W1984629635","https://openalex.org/W1996149691","https://openalex.org/W1996566267","https://openalex.org/W1999631936","https://openalex.org/W2004531476","https://openalex.org/W2009133373","https://openalex.org/W2011187492","https://openalex.org/W2011617651","https://openalex.org/W2032694200","https://openalex.org/W2058785327","https://openalex.org/W2067153744","https://openalex.org/W2090284620","https://openalex.org/W2090496922","https://openalex.org/W2096007233","https://openalex.org/W2109464535","https://openalex.org/W2128348740","https://openalex.org/W2131579868","https://openalex.org/W2138369511","https://openalex.org/W2156220037","https://openalex.org/W2166036638"],"related_works":["https://openalex.org/W2146694787","https://openalex.org/W7100122094","https://openalex.org/W2008761165","https://openalex.org/W2085594479","https://openalex.org/W2370644265","https://openalex.org/W3021220637","https://openalex.org/W2142034208","https://openalex.org/W2025209574","https://openalex.org/W2392074168","https://openalex.org/W1964007188"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}