{"id":"https://openalex.org/W1986238441","doi":"https://doi.org/10.1242/dev.031989","title":"FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism","display_name":"FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism","publication_year":2009,"publication_date":"2009-04-29","ids":{"openalex":"https://openalex.org/W1986238441","doi":"https://doi.org/10.1242/dev.031989","mag":"1986238441","pmid":"https://pubmed.ncbi.nlm.nih.gov/19403660","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680109"},"language":"en","primary_location":{"id":"doi:10.1242/dev.031989","doi":"https://doi.org/10.1242/dev.031989","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.031989","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102722694","display_name":"Aaron J. Thomas","orcid":"https://orcid.org/0000-0001-9280-3350","observed_orcids":["https://orcid.org/0000-0001-9280-3350"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J. Thomas","raw_affiliation_strings":["Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103447106","display_name":"Carol A. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Erickson","raw_affiliation_strings":["Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":4.3714,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.95425958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"136","issue":"11","first_page":"1849","last_page":"1858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4221000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxd3","display_name":"FOXD3","score":1.0},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pax3","display_name":"Pax3","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.8619999885559082},{"id":"https://openalex.org/keywords/melanoblasts","display_name":"melanoblasts","score":0.7699999809265137},{"id":"https://openalex.org/keywords/melanocyte-differentiation","display_name":"melanocyte differentiation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/glial-lineage","display_name":"glial lineage","score":0.703000009059906},{"id":"https://openalex.org/keywords/lineage-switching","display_name":"lineage switch","score":0.6200000047683716},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.7300000190734863},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.9878032207489014},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.9131317734718323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8938482999801636},{"id":"https://openalex.org/C2777302934","wikidata":"https://www.wikidata.org/wiki/Q18031655","display_name":"SOX10","level":4,"score":0.7096127271652222},{"id":"https://openalex.org/C168609215","wikidata":"https://www.wikidata.org/wiki/Q14916248","display_name":"PAX3","level":4,"score":0.6910402178764343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.59796142578125},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4313846230506897},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4108319878578186},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3787752389907837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.344478964805603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2835724949836731},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23335981369018555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15974855422973633},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1430068016052246}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011784","descriptor_name":"Quail","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054338","descriptor_name":"Cell Transdifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.031989","doi":"https://doi.org/10.1242/dev.031989","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.031989","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2680109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:19403660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19403660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2680109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1872666725","display_name":"Training Program in Molecular and Cellular Biology","funder_award_id":"T32GM007377","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1492110909","https://openalex.org/W1543193184","https://openalex.org/W1561162777","https://openalex.org/W1577831909","https://openalex.org/W1579338000","https://openalex.org/W1894858966","https://openalex.org/W1958675029","https://openalex.org/W1963652662","https://openalex.org/W1968263299","https://openalex.org/W1972070768","https://openalex.org/W1972262173","https://openalex.org/W1981101983","https://openalex.org/W1982635732","https://openalex.org/W1985368135","https://openalex.org/W1987340200","https://openalex.org/W1987927770","https://openalex.org/W1994347920","https://openalex.org/W1997830187","https://openalex.org/W1997889534","https://openalex.org/W1999365943","https://openalex.org/W2000146676","https://openalex.org/W2002813441","https://openalex.org/W2007667157","https://openalex.org/W2007834880","https://openalex.org/W2010191673","https://openalex.org/W2013958856","https://openalex.org/W2015086441","https://openalex.org/W2016114470","https://openalex.org/W2026321840","https://openalex.org/W2033239516","https://openalex.org/W2038068782","https://openalex.org/W2045577764","https://openalex.org/W2051718122","https://openalex.org/W2057099402","https://openalex.org/W2057938155","https://openalex.org/W2086042306","https://openalex.org/W2088613950","https://openalex.org/W2089107556","https://openalex.org/W2089415996","https://openalex.org/W2092133045","https://openalex.org/W2092836250","https://openalex.org/W2094036688","https://openalex.org/W2101704916","https://openalex.org/W2106771547","https://openalex.org/W2111311963","https://openalex.org/W2116227695","https://openalex.org/W2120015511","https://openalex.org/W2122229386","https://openalex.org/W2122545078","https://openalex.org/W2124654191","https://openalex.org/W2130743529","https://openalex.org/W2133862424","https://openalex.org/W2145297890","https://openalex.org/W2146650331","https://openalex.org/W2153158998","https://openalex.org/W2153649171","https://openalex.org/W2153671754","https://openalex.org/W2159522663","https://openalex.org/W2161055228","https://openalex.org/W2164927488","https://openalex.org/W2167057063","https://openalex.org/W2170822244","https://openalex.org/W2319085791","https://openalex.org/W2416682908"],"related_works":["https://openalex.org/W2165389148","https://openalex.org/W2121167013","https://openalex.org/W2153158998","https://openalex.org/W2122423011","https://openalex.org/W2152333110","https://openalex.org/W4366184007","https://openalex.org/W2139008939","https://openalex.org/W2092133045","https://openalex.org/W2017478350","https://openalex.org/W1894858966"],"abstract_inverted_index":{"The":[0,37],"first":[1],"neural":[2,9,95,167],"crest":[3,96,168],"cells":[4,17,97,158],"to":[5,29,81,83,112,124,130,139],"emigrate":[6],"from":[7,143],"the":[8,25,45,113,120,126,131,151,163],"tube":[10],"are":[11,19],"specified":[12],"as":[13],"neurons":[14],"and":[15,18,48,72,98,156],"glial":[16,85],"subsequently":[20],"followed":[21],"by":[22,159],"melanocytes":[23],"of":[24,75,89,128,135,166],"skin.":[26],"We":[27,103,146],"wished":[28],"understand":[30],"how":[31],"this":[32],"fate":[33],"switch":[34],"is":[35,41,50,137],"controlled.":[36],"transcriptional":[38,121],"repressor":[39],"FOXD3":[40,56,90,107,149],"expressed":[42,51],"exclusively":[43],"in":[44,53,77,93,99],"neural/glial":[46,155],"precursors":[47],"MITF":[49,64,76,92,114,132,141,161],"only":[52],"melanoblasts.":[54],"Moreover,":[55],"represses":[57,91],"melanogenesis.":[58],"Here":[59],"we":[60],"show":[61,105],"that":[62,73,106,148],"avian":[63],"expression":[65,88,142],"begins":[66],"very":[67],"early":[68,164],"during":[69,162],"melanoblast":[70],"migration":[71],"loss":[74],"melanoblasts":[78],"causes":[79],"them":[80],"transdifferentiate":[82],"a":[84],"phenotype.":[86],"Ectopic":[87],"cultured":[94],"B16-F10":[100],"melanoma":[101],"cells.":[102],"also":[104],"does":[108],"not":[109],"bind":[110],"directly":[111],"promoter,":[115],"but":[116],"instead":[117],"interacts":[118],"with":[119],"activator":[122],"PAX3":[123,129,136],"prevent":[125],"binding":[127],"promoter.":[133],"Overexpression":[134],"sufficient":[138],"rescue":[140],"FOXD3-mediated":[144],"repression.":[145],"conclude":[147],"controls":[150],"lineage":[152],"choice":[153],"between":[154],"pigment":[157],"repressing":[160],"phase":[165],"migration.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
