{"id":"https://openalex.org/W1986228068","doi":"https://doi.org/10.1016/s1072-7515(00)00565-2","title":"CK19 is superior to MUC1 as a marker of micrometastases in patients with non-small cell lung cancer (NSCLC)","display_name":"CK19 is superior to MUC1 as a marker of micrometastases in patients with non-small cell lung cancer (NSCLC)","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W1986228068","doi":"https://doi.org/10.1016/s1072-7515(00)00565-2","mag":"1986228068"},"language":"en","primary_location":{"id":"doi:10.1016/s1072-7515(00)00565-2","doi":"https://doi.org/10.1016/s1072-7515(00)00565-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1072-7515(00)00565-2","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071693096","display_name":"Thomas A. Aloia","orcid":"https://orcid.org/0000-0001-8581-4529","observed_orcids":["https://orcid.org/0000-0001-8581-4529"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A Aloia","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001948668","display_name":"David H. Harpole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H Harpole","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104279784","display_name":"Thomas Anthony D\u2019Amico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A D'Amico","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Duke University Medical Center, Box 31136, Durham, NC, USA 919-684-4891","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"191","issue":"4","first_page":"S62","last_page":"S62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.44190001487731934,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.44190001487731934,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ck19","display_name":"CK19","score":0.9570000171661377},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":1.0},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.9190000295639038},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/bone-marrow-metastasis","display_name":"bone marrow metastasis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/rt-pcr-detection","display_name":"RT-PCR detection","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stage-i-non-small-cell-lung-cancer","display_name":"stage I non-small cell lung cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9767038822174072},{"id":"https://openalex.org/C2778123414","wikidata":"https://www.wikidata.org/wiki/Q2779635","display_name":"Micrometastasis","level":4,"score":0.6610199809074402},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.6374763250350952},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6275317668914795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6116105914115906},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5254273414611816},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48702365159988403},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.44142138957977295},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42314815521240234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40231186151504517},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34463727474212646},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2041904628276825},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1072-7515(00)00565-2","doi":"https://doi.org/10.1016/s1072-7515(00)00565-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1072-7515(00)00565-2","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993081932","https://openalex.org/W2378549916","https://openalex.org/W2379085203","https://openalex.org/W2383536174","https://openalex.org/W331451135","https://openalex.org/W2388645402","https://openalex.org/W3031131031","https://openalex.org/W2186495104","https://openalex.org/W3031314086","https://openalex.org/W2380097189"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,71],"development":[2],"of":[3,7,23,35,48,57],"a":[4,21],"reliable":[5],"marker":[6],"micrometastases":[8,92],"in":[9,93],"patients":[10,24,36,49,94],"with":[11,37,95],"apparently":[12],"localized":[13],"NSCLC":[14,40],"would":[15,26],"improve":[16],"staging":[17],"and":[18,78,86],"may":[19,60],"identify":[20],"cohort":[22],"who":[25],"benefit":[27],"from":[28],"adjuvant":[29],"therapy.":[30],"After":[31],"resection,":[32],"approximately":[33],"30%":[34],"stage":[38],"I":[39],"will":[41],"eventually":[42],"manifest":[43],"metastases.":[44],"Presumably,":[45],"this":[46],"subset":[47],"has":[50],"undetected":[51],"extrathoracic":[52],"disease":[53],"at":[54],"the":[55,81],"time":[56],"resection":[58],"that":[59],"be":[61],"identified":[62],"by":[63],"molecular":[64],"biologic":[65],"techniques":[66],"using":[67],"epithelial":[68,82],"tumor":[69,83],"markers.":[70],"current":[72],"study":[73],"uses":[74],"an":[75],"RT-PCR":[76],"protocol":[77],"primers":[79],"for":[80],"markers,":[84],"CK19":[85],"MUC1,":[87],"to":[88],"detect":[89],"bone":[90],"marrow":[91],"NSCLC.":[96]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}