{"id":"https://openalex.org/W1986202050","doi":"https://doi.org/10.1038/mt.2009.172","title":"Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells","display_name":"Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells","publication_year":2009,"publication_date":"2009-08-13","ids":{"openalex":"https://openalex.org/W1986202050","doi":"https://doi.org/10.1038/mt.2009.172","mag":"1986202050","pmid":"https://pubmed.ncbi.nlm.nih.gov/19638958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2835037"},"language":"en","primary_location":{"id":"doi:10.1038/mt.2009.172","doi":"https://doi.org/10.1038/mt.2009.172","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2009.172","pdf_url":"http://www.cell.com/article/S1525001616308036/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001616308036/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021653930","display_name":"Marita Bosticardo","orcid":"https://orcid.org/0000-0002-1771-4523","observed_orcids":["https://orcid.org/0000-0002-1771-4523"]},"institutions":[{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marita Bosticardo","raw_affiliation_strings":["Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amrita Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Ghosh","raw_affiliation_strings":["Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082561285","display_name":"Yang Du","orcid":"https://orcid.org/0000-0003-2773-1113","observed_orcids":["https://orcid.org/0000-0003-2773-1113"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Du","raw_affiliation_strings":["Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA","Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108403260","display_name":"Nancy A. Jenkins","orcid":"https://orcid.org/0009-0005-1155-9314","observed_orcids":["https://orcid.org/0009-0005-1155-9314","https://orcid.org/0000-0003-1653-6574"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A Jenkins","raw_affiliation_strings":["Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110080713","display_name":"Neal G. Copeland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal G Copeland","raw_affiliation_strings":["Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Cancer Genetics Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062385004","display_name":"Fabio Candotti","orcid":"https://orcid.org/0000-0001-6399-6042","observed_orcids":["https://orcid.org/0000-0001-6399-6042"]},"institutions":[{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fabio Candotti","raw_affiliation_strings":["Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062385004"],"corresponding_institution_ids":["https://openalex.org/I4210090236"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.9083,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.9055745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"11","first_page":"1910","last_page":"1918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moloney-murine-leukemia-virus","display_name":"Moloney murine leukemia virus","score":0.8399999737739563},{"id":"https://openalex.org/keywords/insertional-mutagenesis","display_name":"insertional mutagenesis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oncogene-activation","display_name":"oncogene activation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5429999828338623},{"id":"https://openalex.org/keywords/evi1","display_name":"EVI1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/mef2c","display_name":"MEF2C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hoxa7","display_name":"HOXA7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gene-therapy-safety","display_name":"gene therapy safety","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.8003013730049133},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.797776460647583},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7911490201950073},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.7098432183265686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6924557685852051},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5580551028251648},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5392062067985535},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.5301488637924194},{"id":"https://openalex.org/C118083812","wikidata":"https://www.wikidata.org/wiki/Q1650834","display_name":"Insertion","level":4,"score":0.502758264541626},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4563712179660797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.456104576587677},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39759576320648193},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3531096577644348},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3485219478607178},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2803754210472107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2686246633529663},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2449558675289154},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.18851149082183838},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/mt.2009.172","doi":"https://doi.org/10.1038/mt.2009.172","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2009.172","pdf_url":"http://www.cell.com/article/S1525001616308036/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2835037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2835037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmid:19638958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19638958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/mt.2009.172","doi":"https://doi.org/10.1038/mt.2009.172","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2009.172","pdf_url":"http://www.cell.com/article/S1525001616308036/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986202050.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1573554576","https://openalex.org/W1637867377","https://openalex.org/W1971062917","https://openalex.org/W1971410311","https://openalex.org/W1975530300","https://openalex.org/W1978112031","https://openalex.org/W1982143869","https://openalex.org/W1995684299","https://openalex.org/W1997629459","https://openalex.org/W2001760728","https://openalex.org/W2004067791","https://openalex.org/W2024863470","https://openalex.org/W2027832851","https://openalex.org/W2029255163","https://openalex.org/W2047942455","https://openalex.org/W2057879405","https://openalex.org/W2058895038","https://openalex.org/W2061645642","https://openalex.org/W2071904720","https://openalex.org/W2078149732","https://openalex.org/W2079664984","https://openalex.org/W2083458978","https://openalex.org/W2097606337","https://openalex.org/W2098274099","https://openalex.org/W2107046588","https://openalex.org/W2111967568","https://openalex.org/W2119324304","https://openalex.org/W2137440275","https://openalex.org/W2138214907","https://openalex.org/W2155555885","https://openalex.org/W2157996490","https://openalex.org/W2323613689"],"related_works":["https://openalex.org/W2058895038","https://openalex.org/W2570649395","https://openalex.org/W2049688202","https://openalex.org/W4205764410","https://openalex.org/W2580338926","https://openalex.org/W2499781207","https://openalex.org/W1997993500","https://openalex.org/W2047942455","https://openalex.org/W2467243978","https://openalex.org/W2979979840"],"abstract_inverted_index":{"Insertional":[0],"mutagenesis":[1],"leading":[2],"to":[3,58,144,151,187,207],"insurgence":[4],"of":[5,13,25,35,49,69,90,135,163,179,199,203],"leukemia":[6,99],"has":[7],"been":[8],"shown":[9],"as":[10,75],"a":[11,61],"consequence":[12],"retroviral":[14],"(RV)-mediated":[15],"gene":[16,26,79,194],"transfer":[17],"in":[18,22,63,109,125],"animal":[19],"models":[20],"and":[21,103,129,169],"clinical":[23],"trials":[24],"therapy":[27],"for":[28,78],"X-linked":[29],"severe":[30],"combined":[31],"immunodeficiency.":[32],"Aberrant":[33],"expression":[34],"oncogenes":[36,164],"neighboring":[37],"the":[38,46,50,87,96,106,111,175,180,197,204],"gamma-RV":[39],"vector":[40],"insertion":[41],"site":[42],"via":[43],"induction":[44],"by":[45,154,160,191],"enhancer":[47,71,112,182],"element":[48,113],"viral":[51],"long":[52],"terminal":[53],"repeats":[54],"(LTRs)":[55],"is":[56,157],"thought":[57],"have":[59],"played":[60],"role":[62],"leukemogenesis.":[64],"Consequently,":[65],"RV":[66,92,211],"vectors":[67],"devoid":[68,178],"LTR":[70,102,108,181],"elements":[72],"could":[73],"prove":[74],"safer":[76,209],"tools":[77],"transfer.":[80],"To":[81],"test":[82],"this":[83],"hypothesis,":[84],"we":[85],"evaluated":[86],"immortalization":[88,133,153],"ability":[89],"two":[91],"vectors:":[93],"one":[94,104],"carrying":[95],"full-length":[97],"Moloney":[98],"virus":[100],"(MLV)":[101],"with":[105,121,146],"same":[107],"which":[110],"was":[114,184],"deleted":[115],"[MLV":[116],"self-inactivating":[117],"(SIN)].":[118],"Unexpectedly,":[119],"transduction":[120,145],"MLV":[122,147,155,176],"SIN":[123,156,210],"resulted":[124],"an":[126,200],"only":[127],"slightly":[128],"not":[130],"significant":[131],"decreased":[132],"frequency":[134],"primary":[136],"bone":[137],"marrow":[138],"(BM)":[139],"cultures":[140],"(about":[141,148],"37%)":[142],"compared":[143],"48%).":[149],"Similar":[150],"MLV,":[152],"likely":[158],"caused":[159],"insertional":[161],"activation":[162],"including":[165],"Evi1,":[166],"Mds1,":[167],"Mef2c,":[168],"Hoxa7.":[170],"Our":[171],"results":[172],"indicate":[173],"that":[174],"SIN,":[177],"element,":[183],"still":[185],"able":[186],"immortalize":[188],"BM":[189],"cells":[190],"activating":[192],"nearby":[193],"expression,":[195],"indicating":[196],"need":[198],"accurate":[201],"selection":[202],"internal":[205],"promoter":[206],"obtain":[208],"vectors.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}