{"id":"https://openalex.org/W1986177147","doi":"https://doi.org/10.1371/journal.pone.0065718","title":"Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy","display_name":"Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy","publication_year":2013,"publication_date":"2013-06-06","ids":{"openalex":"https://openalex.org/W1986177147","doi":"https://doi.org/10.1371/journal.pone.0065718","mag":"1986177147","pmid":"https://pubmed.ncbi.nlm.nih.gov/23762415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675076"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0065718","doi":"https://doi.org/10.1371/journal.pone.0065718","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065718","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065718&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065718&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012455396","display_name":"Sonia Coni","orcid":"https://orcid.org/0000-0002-0295-8904","observed_orcids":["https://orcid.org/0000-0002-0295-8904"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210117840","display_name":"Institut de Biologie Valrose","ror":"https://ror.org/03bnma344","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210117840"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sonia Coni","raw_affiliation_strings":["CNRS UMR 7277, Inserm 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France","Universit\u00e9 de Nice-Sophia Antipolis, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 7277, Inserm 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210117840"]},{"raw_affiliation_string":"Universit\u00e9 de Nice-Sophia Antipolis, Nice, France","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001192190","display_name":"Laura Antonucci","orcid":"https://orcid.org/0000-0001-8965-2432","observed_orcids":["https://orcid.org/0000-0001-8965-2432"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Antonucci","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011226747","display_name":"Davide Francesco D'Amico","orcid":"https://orcid.org/0000-0002-8499-9514","observed_orcids":["https://orcid.org/0000-0002-8499-9514"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide D'Amico","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000313152","display_name":"Laura Di Magno","orcid":"https://orcid.org/0000-0001-9446-8752","observed_orcids":["https://orcid.org/0000-0001-9446-8752"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Di Magno","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012691987","display_name":"Paola Infante","orcid":"https://orcid.org/0000-0003-0682-3916","observed_orcids":["https://orcid.org/0000-0003-0682-3916"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Infante","raw_affiliation_strings":["Center for Life Nano, Istituto Italiano di Tecnologia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano, Istituto Italiano di Tecnologia, Rome, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004885916","display_name":"Enrico De Smaele","orcid":"https://orcid.org/0000-0003-4524-4423","observed_orcids":["https://orcid.org/0000-0003-4524-4423"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico De Smaele","raw_affiliation_strings":["Department of Experimental Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013727905","display_name":"Giuseppe Giannini","orcid":"https://orcid.org/0000-0003-0299-4056","observed_orcids":["https://orcid.org/0000-0003-0299-4056"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Giannini","raw_affiliation_strings":["Department of Experimental Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044346256","display_name":"Lucia Di Marcotullio","orcid":"https://orcid.org/0000-0003-0274-7178","observed_orcids":["https://orcid.org/0000-0003-0274-7178"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Di Marcotullio","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047735457","display_name":"Isabella Screpanti","orcid":"https://orcid.org/0000-0001-8071-9098","observed_orcids":["https://orcid.org/0000-0001-8071-9098"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Isabella Screpanti","raw_affiliation_strings":["Center for Life Nano, Istituto Italiano di Tecnologia, Rome, Italy","Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano, Istituto Italiano di Tecnologia, Rome, Italy","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108135067","display_name":"Alberto Gulino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alberto Gulino","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","IRCCS Neuromed, Pozzilli, Isernia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Isernia, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052670103","display_name":"Gianluca Canettieri","orcid":"https://orcid.org/0000-0001-6694-2613","observed_orcids":["https://orcid.org/0000-0001-6694-2613"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Canettieri","raw_affiliation_strings":["Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Rome \u201cLa Sapienza\u201d, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012691987","https://openalex.org/A5047735457","https://openalex.org/A5052670103","https://openalex.org/A5108135067"],"corresponding_institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I30771326","https://openalex.org/I861853513"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6394,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.91102154,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"e65718","last_page":"e65718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gli2","display_name":"GLI2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lysine-acetylation","display_name":"lysine acetylation","score":0.871999979019165},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9649999737739563},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cerebellar-development","display_name":"cerebellar development","score":0.906000018119812},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C120407494","wikidata":"https://www.wikidata.org/wiki/Q14886491","display_name":"GLI2","level":4,"score":0.8659532070159912},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.7013179063796997},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.692909300327301},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6640081405639648},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.595703661441803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5308296084403992},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5118016600608826},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.49948883056640625},{"id":"https://openalex.org/C145837895","wikidata":"https://www.wikidata.org/wiki/Q18031607","display_name":"Smoothened","level":4,"score":0.48233291506767273},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4503919780254364},{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.44551539421081543},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44028687477111816},{"id":"https://openalex.org/C2911110750","wikidata":"https://www.wikidata.org/wiki/Q7117884","display_name":"P300-CBP Transcription Factors","level":5,"score":0.42842909693717957},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40274810791015625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3578330874443054},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34908556938171387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31903624534606934},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.24361136555671692},{"id":"https://openalex.org/C2910921701","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone Acetyltransferases","level":4,"score":0.1799246370792389},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10340896248817444}],"mesh":[{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075746","descriptor_name":"Zinc Finger Protein Gli2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099224","descriptor_name":"p300-CBP-Associated Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0065718","doi":"https://doi.org/10.1371/journal.pone.0065718","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065718","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065718&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2676172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675076","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23762415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23762415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3675076","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3675076/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.7405","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.7405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9a/f7/pone.0065718.PMC3675076.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d0f7b0ce58964deda87d004e4dc4ad38","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d0f7b0ce58964deda87d004e4dc4ad38","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 6, p e65718 (2013)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/543166","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/543166","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0065718","doi":"https://doi.org/10.1371/journal.pone.0065718","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065718","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065718&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322750","display_name":"Istituto Pasteur-Fondazione Cenci Bolognetti","ror":"https://ror.org/051v7w268"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320325847","display_name":"Istituto Italiano di Tecnologia","ror":"https://ror.org/042t93s57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986177147.pdf","grobid_xml":"https://content.openalex.org/works/W1986177147.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1566344473","https://openalex.org/W1964731706","https://openalex.org/W2006100936","https://openalex.org/W2013248580","https://openalex.org/W2013579158","https://openalex.org/W2016280793","https://openalex.org/W2034614265","https://openalex.org/W2039640335","https://openalex.org/W2065431340","https://openalex.org/W2082541302","https://openalex.org/W2083312389","https://openalex.org/W2086078758","https://openalex.org/W2124936055","https://openalex.org/W2132749637","https://openalex.org/W2158915464","https://openalex.org/W2163007274","https://openalex.org/W2339231403","https://openalex.org/W4233036449"],"related_works":["https://openalex.org/W2473781720","https://openalex.org/W3003728324","https://openalex.org/W2016280793","https://openalex.org/W2066711817","https://openalex.org/W2043152231","https://openalex.org/W7099633368","https://openalex.org/W2399137066","https://openalex.org/W2120604573","https://openalex.org/W2113303160","https://openalex.org/W1998777048"],"abstract_inverted_index":{"The":[0,16,63],"morphogenic":[1],"Hedgehog":[2,61,157],"(Hh)":[3],"signaling":[4,180],"regulates":[5],"postnatal":[6],"cerebellar":[7],"development":[8],"and":[9,20,28,41,51,104,121],"its":[10],"aberrant":[11],"activation":[12,154],"leads":[13],"to":[14],"medulloblastoma.":[15],"transcription":[17],"factors":[18],"Gli1":[19],"Gli2":[21,47,74,96,111,120,149,164,186],"are":[22],"the":[23,76,153,178,195],"activators":[24],"of":[25,136,145,156,175,177,197],"Hh":[26,82,108,127,179],"pathway":[27],"their":[29],"function":[30],"is":[31,48,98,105,115,122],"finely":[32],"controlled":[33],"by":[34,107,126],"different":[35],"covalent":[36],"modifications,":[37],"such":[38],"as":[39,189],"phosphorylation":[40],"ubiquitination.":[42],"We":[43],"show":[44],"here":[45],"that":[46,52,95,130],"endogenously":[49],"acetylated":[50],"this":[53],"modification":[54],"represents":[55,132],"a":[56,88,172,190],"key":[57,191],"regulatory":[58],"step":[59],"for":[60,138],"signaling.":[62,158],"histone":[64],"acetyltransferase":[65],"(HAT)":[66],"coactivator":[67],"p300,":[68],"but":[69],"not":[70],"other":[71],"HATs,":[72],"acetylates":[73],"at":[75,101,161],"conserved":[77],"lysine":[78],"K757":[79,162],"thus":[80],"inhibiting":[81],"target":[83],"gene":[84],"expression.":[85],"By":[86],"generating":[87],"specific":[89],"anti":[90],"acetyl-Gli2(Lys757)":[91],"antisera":[92],"we":[93],"demonstrated":[94],"acetylation":[97,131,150,160,187],"readily":[99],"detectable":[100],"endogenous":[102],"levels":[103],"attenuated":[106],"agonists.":[109],"Moreover,":[110],"K757R":[112],"mutant":[113],"activity":[114],"higher":[116],"than":[117],"wild":[118],"type":[119],"no":[123],"longer":[124],"enhanced":[125],"agonists,":[128],"indicating":[129],"an":[133],"additional":[134],"level":[135],"control":[137,196],"signal":[139],"dependent":[140],"activation.":[141],"Consistently,":[142],"in":[143,182,194],"sections":[144],"developing":[146],"mouse":[147],"cerebella":[148],"correlates":[151],"with":[152,184],"status":[155],"Mechanistically,":[159],"prevents":[163],"entry":[165],"into":[166],"chromatin.":[167],"Together,":[168],"these":[169],"data":[170],"illustrate":[171],"novel":[173],"mechanism":[174],"regulation":[176],"whereby,":[181],"concert":[183],"Gli1,":[185],"functions":[188],"transcriptional":[192],"checkpoint":[193],"morphogen-dependent":[198],"processes.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}