{"id":"https://openalex.org/W1986137495","doi":"https://doi.org/10.1074/jbc.m112399200","title":"Role of Tyrosine Kinase Jak2 in Prolactin-induced Differentiation and Growth of Mammary Epithelial Cells","display_name":"Role of Tyrosine Kinase Jak2 in Prolactin-induced Differentiation and Growth of Mammary Epithelial Cells","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1986137495","doi":"https://doi.org/10.1074/jbc.m112399200","mag":"1986137495","pmid":"https://pubmed.ncbi.nlm.nih.gov/11821424"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112399200","doi":"https://doi.org/10.1074/jbc.m112399200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112399200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m112399200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076138484","display_name":"Jianwu Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianwu Xie","raw_affiliation_strings":["United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109413131","display_name":"Matthew J. LeBaron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. LeBaron","raw_affiliation_strings":["United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072652868","display_name":"Marja T. Nevalainen","orcid":"https://orcid.org/0000-0003-2273-6396","observed_orcids":["https://orcid.org/0000-0003-2273-6396","https://orcid.org/0009-0008-8593-078X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marja T. Nevalainen","raw_affiliation_strings":["United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065798455","display_name":"Hallgeir Rui","orcid":"https://orcid.org/0000-0002-8778-261X","observed_orcids":["https://orcid.org/0000-0002-8778-261X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hallgeir Rui","raw_affiliation_strings":["United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"From the United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065798455"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4034,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.79382574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"277","issue":"16","first_page":"14020","last_page":"14030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.781000018119812},{"id":"https://openalex.org/keywords/prolactin-receptor","display_name":"prolactin receptor","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mammary-epithelial-cell-differentiation","display_name":"mammary epithelial cell differentiation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.8029999732971191},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hc11-cells","display_name":"HC11 cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.8225787878036499},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.6450316905975342},{"id":"https://openalex.org/C32465701","wikidata":"https://www.wikidata.org/wiki/Q14914514","display_name":"Janus kinase 2","level":3,"score":0.6443699598312378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6419119834899902},{"id":"https://openalex.org/C2781031661","wikidata":"https://www.wikidata.org/wiki/Q2738985","display_name":"Prolactin receptor","level":4,"score":0.5814606547355652},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4723566472530365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4717058837413788},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4558284878730774},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4352427124977112},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42394426465034485},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4215894937515259},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4108901619911194},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3542500138282776},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14953318238258362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08662763237953186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07527884840965271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05512315034866333}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m112399200","doi":"https://doi.org/10.1074/jbc.m112399200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112399200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11821424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11821424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112399200","doi":"https://doi.org/10.1074/jbc.m112399200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112399200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3503891750","display_name":"TARGETING OF TYROSINE KINASE PATHWAYS IN PROSTATE CANCER","funder_award_id":"R01CA083813","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G390088705","display_name":"Prolactin Induced Phosphoprotein Signal Transduction","funder_award_id":"R01DK052013","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8176433979","display_name":null,"funder_award_id":"R074JW","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W4553897","https://openalex.org/W132416300","https://openalex.org/W1484122498","https://openalex.org/W1486018587","https://openalex.org/W1569274669","https://openalex.org/W1805210392","https://openalex.org/W1893961135","https://openalex.org/W1942718916","https://openalex.org/W1969890794","https://openalex.org/W1977341142","https://openalex.org/W1989234467","https://openalex.org/W1998351354","https://openalex.org/W2002782759","https://openalex.org/W2011030679","https://openalex.org/W2012460327","https://openalex.org/W2019931350","https://openalex.org/W2027804163","https://openalex.org/W2039777176","https://openalex.org/W2044219252","https://openalex.org/W2044796256","https://openalex.org/W2074356752","https://openalex.org/W2120044211","https://openalex.org/W2128752930","https://openalex.org/W2147028876","https://openalex.org/W2156980924","https://openalex.org/W2158842626","https://openalex.org/W2165808595","https://openalex.org/W2330829715"],"related_works":["https://openalex.org/W2063794904","https://openalex.org/W12212036","https://openalex.org/W2145299570","https://openalex.org/W2081408694","https://openalex.org/W2115121430","https://openalex.org/W2133196685","https://openalex.org/W2110803617","https://openalex.org/W2140751959","https://openalex.org/W1539327066","https://openalex.org/W1990530481"],"abstract_inverted_index":{"Genetic":[0],"studies":[1],"in":[2,16,29,60,65,82,98,137,147,183,201],"mice":[3,58],"have":[4],"established":[5],"a":[6,109,119,159],"critical":[7],"role":[8,79,196],"for":[9,130],"prolactin":[10,25,49],"receptors":[11,26,50],"and":[12,27,51,87,114,133,158,169,181],"transcription":[13],"factor":[14],"Stat5":[15,28,136],"mammary":[17,72,102,140,185],"gland":[18],"differentiation.":[19],"However,":[20],"the":[21,78,195,198],"enzymatic":[22],"coupling":[23],"between":[24],"this":[30],"process":[31],"has":[32],"not":[33],"been":[34],"established.":[35],"In":[36],"addition":[37],"to":[38,76,95],"Jak2,":[39],"several":[40],"other":[41],"tyrosine":[42],"kinases":[43],"reportedly":[44],"also":[45],"are":[46],"associated":[47,151],"with":[48,152],"may":[52,190],"phosphorylate":[53],"Stat5.":[54],"Because":[55],"Jak2":[56,64,81,97,111,121,127,146,178],"null":[57],"die":[59],"utero,":[61],"we":[62],"targeted":[63],"an":[66],"ex":[67],"vivo":[68],"model":[69],"of":[70,80,84,108,118,135,145,155,197],"prolactin-induced":[71,131],"epithelial":[73,103,141,186],"cell":[74,85],"differentiation":[75,86,132],"determine":[77],"regulation":[83],"growth.":[88],"Two":[89],"independent":[90],"targeting":[91],"strategies":[92],"were":[93],"used":[94],"suppress":[96],"immortalized":[99],"HC11":[100,148],"mouse":[101,139],"cells:":[104],"1)":[105],"stable":[106],"expression":[107],"specific":[110],"antisense":[112],"construct":[113],"2)":[115],"adenoviral":[116],"delivery":[117],"dominant-negative":[120],"gene.":[122],"We":[123],"now":[124],"demonstrate":[125],"that":[126,177,189],"is":[128,179],"essential":[129],"activation":[134,154],"normal":[138,184],"cells.":[142],"Furthermore,":[143],"suppression":[144],"cells":[149],"was":[150],"constitutive":[153],"oncoprotein":[156],"Stat3":[157],"hyperproliferative":[160],"phenotype":[161],"characterized":[162],"by":[163],"increased":[164],"mitotic":[165],"rate,":[166],"reduced":[167,170],"apoptosis,":[168],"contact":[171],"inhibition.":[172],"Collectively,":[173],"our":[174],"data":[175],"suggest":[176],"differentiation-inducing":[180],"growth-inhibitory":[182],"cells,":[187],"observations":[188],"shed":[191],"new":[192],"light":[193],"on":[194],"Jak2-Stat5":[199],"pathway":[200],"breast":[202],"cancer.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
