{"id":"https://openalex.org/W1986128576","doi":"https://doi.org/10.1038/ncomms2628","title":"CSN- and CAND1-dependent remodelling of the budding yeast SCF complex","display_name":"CSN- and CAND1-dependent remodelling of the budding yeast SCF complex","publication_year":2013,"publication_date":"2013-03-27","ids":{"openalex":"https://openalex.org/W1986128576","doi":"https://doi.org/10.1038/ncomms2628","mag":"1986128576","pmid":"https://pubmed.ncbi.nlm.nih.gov/23535662"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms2628","doi":"https://doi.org/10.1038/ncomms2628","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms2628","pdf_url":"https://www.nature.com/articles/ncomms2628.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/ncomms2628.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038801188","display_name":"Aleksandra Zemla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aleksandra Zemla","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yann Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yann Thomas","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751356","display_name":"Sylwia K\u0119dziora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sylwia Kedziora","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024724887","display_name":"Axel Knebel","orcid":"https://orcid.org/0000-0002-9197-6054","observed_orcids":["https://orcid.org/0000-0002-9197-6054"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Axel Knebel","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052614432","display_name":"Nicola T. Wood","orcid":"https://orcid.org/0000-0002-3347-6625","observed_orcids":["https://orcid.org/0000-0002-3347-6625"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola T. Wood","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040850313","display_name":"Gw\u00e9na\u00ebl E. E. Rabut","orcid":"https://orcid.org/0000-0003-2658-2769","observed_orcids":["https://orcid.org/0000-0003-2658-2769"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210127029","display_name":"Institut de g\u00e9n\u00e9tique et de d\u00e9veloppement de Rennes","ror":"https://ror.org/036xhtv26","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210127029","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I4405258264","display_name":"Universit\u00e9 Rennes 1","ror":"https://ror.org/00crteh33","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258264","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gwena\u00ebl Rabut","raw_affiliation_strings":["CNRS, Universit\u00e9 Rennes 1, Institut de G\u00e9n\u00e9tique et D\u00e9veloppement de Rennes, 2 avenue du Professeur L\u00e9on Bernard, CS 34317, Rennes Cedex, 35043, France","CNRS, Universit\u00e9 Rennes 1, Institut de G\u00e9n\u00e9tique et D\u00e9veloppement de Rennes, 2 avenue du Professeur L\u00e9on Bernard, CS 34317, Rennes Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Universit\u00e9 Rennes 1, Institut de G\u00e9n\u00e9tique et D\u00e9veloppement de Rennes, 2 avenue du Professeur L\u00e9on Bernard, CS 34317, Rennes Cedex, 35043, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127029","https://openalex.org/I4405258264","https://openalex.org/I56067802"]},{"raw_affiliation_string":"CNRS, Universit\u00e9 Rennes 1, Institut de G\u00e9n\u00e9tique et D\u00e9veloppement de Rennes, 2 avenue du Professeur L\u00e9on Bernard, CS 34317, Rennes Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210127029","https://openalex.org/I4405258264","https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049577833","display_name":"Thimo Kurz","orcid":"https://orcid.org/0000-0003-0700-6993","observed_orcids":["https://orcid.org/0000-0003-0700-6993"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thimo Kurz","raw_affiliation_strings":["Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Scottish Institute for Cell Signalling, Protein Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049577833"],"corresponding_institution_ids":["https://openalex.org/I177639307"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.6189,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.96433884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"1641","last_page":"1641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cand1","display_name":"CAND1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cop9-signalosome","display_name":"COP9 signalosome","score":0.9409999847412109},{"id":"https://openalex.org/keywords/scf-ubiquitin-ligase","display_name":"SCF ubiquitin ligase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cullin-neddylation","display_name":"cullin neddylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/deneddylation","display_name":"deneddylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/carbon-source-shift","display_name":"carbon source shift","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.8350430130958557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7417761087417603},{"id":"https://openalex.org/C45005369","wikidata":"https://www.wikidata.org/wiki/Q21115705","display_name":"Neddylation","level":5,"score":0.7376325726509094},{"id":"https://openalex.org/C2778884322","wikidata":"https://www.wikidata.org/wiki/Q14905184","display_name":"COP9 signalosome","level":5,"score":0.725191593170166},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5879287719726562},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5760897397994995},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.5750283002853394},{"id":"https://openalex.org/C2779231659","wikidata":"https://www.wikidata.org/wiki/Q6953444","display_name":"NEDD8","level":5,"score":0.5696132779121399},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5576255917549133},{"id":"https://openalex.org/C162863750","wikidata":"https://www.wikidata.org/wiki/Q5058186","display_name":"Cell division control protein 4","level":5,"score":0.540717601776123},{"id":"https://openalex.org/C2775868145","wikidata":"https://www.wikidata.org/wiki/Q18031515","display_name":"Skp1","level":5,"score":0.502565860748291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4853293001651764},{"id":"https://openalex.org/C131312102","wikidata":"https://www.wikidata.org/wiki/Q5423632","display_name":"F-box protein","level":5,"score":0.480384886264801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.311983585357666},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18856051564216614},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1373504102230072},{"id":"https://openalex.org/C2908981932","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Peptide Hydrolases","level":4,"score":0.0},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/ncomms2628","doi":"https://doi.org/10.1038/ncomms2628","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms2628","pdf_url":"https://www.nature.com/articles/ncomms2628.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:23535662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23535662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:138902","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/138902/1/138902.pdf","pdf_url":"http://eprints.gla.ac.uk/138902/1/138902.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.645.9472","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.645.9472","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hal-univ-rennes1.archives-ouvertes.fr/docs/00/96/61/27/PDF/ncomms2628-Open-access-CC-BY-NC-ND.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00966127v1","doi":null,"is_oa":true,"landing_page_url":"https://univ-rennes.hal.science/hal-00966127","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 2013, 4, pp.1641. ⟨10.1038/ncomms2628⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2628","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms2628","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/d71f5de1-d566-4f79-9c8b-3dc0d628636e","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/d71f5de1-d566-4f79-9c8b-3dc0d628636e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zemla, A, Thomas, Y, Kedziora, S, Knebel, A, Wood, N T, Rabut, G & Kurz, T 2013, 'CSN-and CAND1-dependent remodelling of the budding yeast SCF complex', Nature Communications, vol. 4, 1641. https://doi.org/10.1038/ncomms2628","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/ncomms2628","doi":"https://doi.org/10.1038/ncomms2628","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms2628","pdf_url":"https://www.nature.com/articles/ncomms2628.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"},{"id":"https://openalex.org/F4320313269","display_name":"Scottish Government","ror":"https://ror.org/04v2xmd71"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986128576.pdf","grobid_xml":"https://content.openalex.org/works/W1986128576.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1498526978","https://openalex.org/W1519084876","https://openalex.org/W1539814399","https://openalex.org/W1541556706","https://openalex.org/W1549578642","https://openalex.org/W1553415829","https://openalex.org/W1966034049","https://openalex.org/W1978878131","https://openalex.org/W1988031203","https://openalex.org/W1988157819","https://openalex.org/W1991000990","https://openalex.org/W1994127726","https://openalex.org/W2003062513","https://openalex.org/W2006082315","https://openalex.org/W2009212080","https://openalex.org/W2013057562","https://openalex.org/W2017878438","https://openalex.org/W2022151688","https://openalex.org/W2022170463","https://openalex.org/W2026313115","https://openalex.org/W2026619158","https://openalex.org/W2032590709","https://openalex.org/W2032820757","https://openalex.org/W2035599991","https://openalex.org/W2044757757","https://openalex.org/W2047395555","https://openalex.org/W2055198091","https://openalex.org/W2068652435","https://openalex.org/W2074676459","https://openalex.org/W2094001022","https://openalex.org/W2094021381","https://openalex.org/W2101913031","https://openalex.org/W2122674109","https://openalex.org/W2124938253","https://openalex.org/W2126863927","https://openalex.org/W2137770315","https://openalex.org/W2138822307","https://openalex.org/W2139627774","https://openalex.org/W2140219059","https://openalex.org/W2140252926","https://openalex.org/W2143395036","https://openalex.org/W2144114582","https://openalex.org/W2149931676","https://openalex.org/W2154419094","https://openalex.org/W2157057002","https://openalex.org/W2166987747","https://openalex.org/W2171186199","https://openalex.org/W2172095542","https://openalex.org/W2620591598","https://openalex.org/W2774864460"],"related_works":["https://openalex.org/W2997879126","https://openalex.org/W2014565561","https://openalex.org/W2074676459","https://openalex.org/W2313629931","https://openalex.org/W2755064430","https://openalex.org/W2035599991","https://openalex.org/W4381251718","https://openalex.org/W1994127726","https://openalex.org/W2059082923","https://openalex.org/W2086955443"],"abstract_inverted_index":{"Cullin\u2013RING":[0,62,161],"ligases":[1],"(CRLs)":[2],"are":[3,15,64,72],"ubiquitin":[4,162],"E3":[5],"enzymes":[6],"with":[7,23,42],"variable":[8],"substrate-adaptor":[9],"and":[10,115,131,193],"-receptor":[11],"subunits.":[12],"All":[13],"CRLs":[14],"activated":[16],"by":[17,91],"modification":[18],"of":[19,109,160,171],"the":[20,24,92,107,134,158,172],"cullin":[21,135],"subunit":[22],"ubiquitin-like":[25],"protein":[26,30],"Nedd8":[27],"(neddylation).":[28],"The":[29,46],"CAND1":[31,83,127,156,196],"(Cullin-associated-Nedd8-dissociated-1)":[32],"also":[33,146],"promotes":[34,84,157],"CRL":[35,129],"activity,":[36],"even":[37],"though":[38],"it":[39],"only":[40,140],"interacts":[41],"inactive":[43,168],"ligase":[44],"complexes.":[45],"molecular":[47],"mechanism":[48],"underlying":[49],"this":[50,182,191],"behaviour":[51],"remains":[52],"largely":[53],"unclear.":[54],"Here,":[55],"we":[56],"find":[57],"that":[58,133,195],"yeast":[59],"SCF":[60,89,113],"(Skp1\u2013Cdc53\u2013F-box)":[61],"complexes":[63,111],"remodelled":[65],"in":[66,76,117,184],"a":[67,176],"CAND1-dependent":[68],"manner,":[69],"when":[70],"cells":[71,99],"switched":[73],"from":[74],"growth":[75],"fermentable":[77],"to":[78,101,142,147,167,179],"non-fermentable":[79],"carbon":[80],"sources.":[81],"Mechanistically,":[82],"substrate":[85,103,118,149,153,203],"adaptor":[86,154],"release":[87,102],"following":[88],"deneddylation":[90],"COP9":[93],"signalosome":[94],"(CSN).":[95],"CSN-":[96],"or":[97],"CAND1-mutant":[98],"fail":[100],"adaptors.":[104,204],"This":[105],"delays":[106],"formation":[108],"new":[110],"during":[112],"reactivation":[114],"results":[116,122],"degradation":[119],"defects.":[120],"Our":[121],"shed":[123],"light":[124],"on":[125],"how":[126],"regulates":[128],"activity":[130,159],"demonstrate":[132],"neddylation\u2013deneddylation":[136],"cycle":[137],"is":[138],"not":[139],"required":[141],"activate":[143,181],"CRLs,":[144],"but":[145,164],"regulate":[148],"specificity":[150],"through":[151],"dynamic":[152],"exchange.":[155],"ligases,":[163],"binds":[165],"exclusively":[166],"unneddylated":[169],"forms":[170],"enzyme.":[173],"By":[174],"identifying":[175],"simple":[177],"means":[178],"reversibly":[180],"complex":[183],"budding":[185],"yeast,":[186],"Zemla":[187],"et":[188],"al.":[189],"resolve":[190],"paradox":[192],"show":[194],"acts":[197],"as":[198],"an":[199],"exchange":[200],"factor":[201],"for":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}