{"id":"https://openalex.org/W1986124091","doi":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","title":"Mitochondria as all\u2010round players of the calcium game","display_name":"Mitochondria as all\u2010round players of the calcium game","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W1986124091","doi":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","mag":"1986124091","pmid":"https://pubmed.ncbi.nlm.nih.gov/11080249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2270183"},"language":"en","primary_location":{"id":"doi:10.1111/j.1469-7793.2000.00037.x","doi":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2270183/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027748782","display_name":"Rosario Rizzuto","orcid":"https://orcid.org/0000-0001-7044-5097","observed_orcids":["https://orcid.org/0000-0001-7044-5097"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosario Rizzuto","raw_affiliation_strings":["Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy. r.rizzuto@unife.it","Dept of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy. r.rizzuto@unife.it","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Dept of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009191571","display_name":"Paolo Bernardi","orcid":"https://orcid.org/0000-0001-9187-3736","observed_orcids":["https://orcid.org/0000-0001-9187-3736"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Bernardi","raw_affiliation_strings":["Department of Biomedical Sciences and CNR Centre for the Study of Biomembranes, University of Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and CNR Centre for the Study of Biomembranes, University of Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086295692","display_name":"Tullio Pozzan","orcid":"https://orcid.org/0000-0002-0498-2641","observed_orcids":["https://orcid.org/0000-0002-0498-2641"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tullio Pozzan","raw_affiliation_strings":["Department of Biomedical Sciences and CNR Centre for the Study of Biomembranes, University of Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and CNR Centre for the Study of Biomembranes, University of Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":2.309,"has_fulltext":false,"cited_by_count":569,"citation_normalized_percentile":{"value":0.90795455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"529","issue":"1","first_page":"37","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.890999972820282},{"id":"https://openalex.org/keywords/mitochondrial-matrix-calcium","display_name":"mitochondrial matrix calcium","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8429214954376221},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6906542181968689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6469628810882568},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.6387234926223755},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6198183298110962},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5583399534225464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5066621899604797},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.4563508629798889},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.41890469193458557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3856986463069916},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.345791220664978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3316679000854492},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3118475079536438},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.20420315861701965},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1555323600769043},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1469-7793.2000.00037.x","doi":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7793.2000.00037.x","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:11080249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11080249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2270183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2270183/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmh:oai:www.research.unipd.it:11577/2471855","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2471855","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2270183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2270183/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W408505","https://openalex.org/W321671147","https://openalex.org/W1484348587","https://openalex.org/W1494239480","https://openalex.org/W1535022915","https://openalex.org/W1540106294","https://openalex.org/W1545240325","https://openalex.org/W1559795048","https://openalex.org/W1564917523","https://openalex.org/W1569293583","https://openalex.org/W1580567817","https://openalex.org/W1648000881","https://openalex.org/W1677042470","https://openalex.org/W1851479110","https://openalex.org/W1920479129","https://openalex.org/W1935060748","https://openalex.org/W1939705865","https://openalex.org/W1963791094","https://openalex.org/W1968789295","https://openalex.org/W1969914617","https://openalex.org/W1975551314","https://openalex.org/W1979516784","https://openalex.org/W1986560775","https://openalex.org/W1998595310","https://openalex.org/W2008479138","https://openalex.org/W2008757109","https://openalex.org/W2009301053","https://openalex.org/W2014470707","https://openalex.org/W2014521614","https://openalex.org/W2022250720","https://openalex.org/W2022408354","https://openalex.org/W2023707009","https://openalex.org/W2028023732","https://openalex.org/W2032781637","https://openalex.org/W2037693401","https://openalex.org/W2043992655","https://openalex.org/W2046353863","https://openalex.org/W2048891569","https://openalex.org/W2053697597","https://openalex.org/W2056786731","https://openalex.org/W2060081012","https://openalex.org/W2063817664","https://openalex.org/W2064974999","https://openalex.org/W2065520371","https://openalex.org/W2070664966","https://openalex.org/W2073706613","https://openalex.org/W2077996001","https://openalex.org/W2079457311","https://openalex.org/W2080163146","https://openalex.org/W2080312195","https://openalex.org/W2082722322","https://openalex.org/W2083038107","https://openalex.org/W2091739562","https://openalex.org/W2092077944","https://openalex.org/W2107198564","https://openalex.org/W2114228694","https://openalex.org/W2123884956","https://openalex.org/W2139052757","https://openalex.org/W2141000153","https://openalex.org/W2141188578","https://openalex.org/W2150200455","https://openalex.org/W2163529058","https://openalex.org/W2171240877","https://openalex.org/W2337640397","https://openalex.org/W2413324496"],"related_works":["https://openalex.org/W1573314270","https://openalex.org/W2111350784","https://openalex.org/W1969709153","https://openalex.org/W1601185296","https://openalex.org/W2142003218","https://openalex.org/W2034862605","https://openalex.org/W2483896090","https://openalex.org/W2075577996","https://openalex.org/W2632098976","https://openalex.org/W2906799341"],"abstract_inverted_index":{"Although":[0],"it":[1],"has":[2,49,82,117],"been":[3,51],"known":[4],"for":[5,199],"over":[6],"three":[7],"decades":[8],"that":[9,21,33,36,214],"mitochondria":[10,187],"are":[11,27],"endowed":[12],"with":[13,78],"a":[14,85,105],"complex":[15],"array":[16],"of":[17,24,40,59,67,75,88,121,136,150,154,159,170,181,196,206,216],"Ca2+":[18,47,99,123,156,172,190,197,209,218],"transporters":[19,62,157],"and":[20,63,125,158,177,188,203,211],"key":[22,179],"enzymes":[23],"mitochondrial":[25,46,61,76,113,122,171,201,217],"metabolism":[26],"regulated":[28],"by":[29,91,104],"Ca2+,":[30],"the":[31,38,41,56,60,64,68,97,112,119,134,147,151,155,160,168,178,186,189,193,204,207],"possibility":[32],"physiological":[34,194],"stimuli":[35],"raise":[37],"[Ca2+]":[39,70,77,110],"cytoplasm":[42],"could":[43],"trigger":[44],"major":[45],"uptake":[48,173],"long":[50],"considered":[52],"unlikely,":[53],"based":[54],"on":[55,142],"low":[57],"affinity":[58],"limited":[65],"amplitude":[66],"cytoplasmic":[69,98,208],"rises.":[71],"The":[72],"direct":[73],"measurement":[74],"highly":[79],"selective":[80],"probes":[81],"led":[83],"to":[84],"complete":[86],"reversion":[87],"this":[89],"view,":[90],"demonstrating":[92],"that,":[93],"after":[94],"cell":[95],"stimulation,":[96],"signal":[100],"is":[101],"always":[102],"paralleled":[103],"much":[106],"larger":[107],"rise":[108],"in":[109,111,133,174,222],"matrix.":[114],"This":[115],"observation":[116],"rejuvenated":[118],"study":[120],"transport":[124,198],"novel,":[126],"unexpected":[127],"results":[128],"have":[129],"altered":[130],"long-standing":[131],"dogmas":[132],"field":[135],"calcium":[137],"signalling.":[138],"Here":[139],"we":[140],"focus":[141],"four":[143],"main":[144],"topics:":[145],"(i)":[146],"current":[148],"knowledge":[149],"functional":[152],"properties":[153],"thermodynamic":[161],"constraints":[162],"under":[163],"which":[164],"they":[165],"operate;":[166],"(ii)":[167],"occurrence":[169],"living":[175],"cells":[176],"role":[180],"local":[182],"signalling":[183,219],"routes":[184],"between":[185],"sources;":[191],"(iii)":[192],"consequences":[195],"both":[200],"function":[202],"modulation":[205],"signal;":[210],"(iv)":[212],"evidence":[213],"alterations":[215],"may":[220],"occur":[221],"pathophysiological":[223],"conditions.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}