{"id":"https://openalex.org/W1986112802","doi":"https://doi.org/10.1097/wnf.0b013e318157d998","title":"Adjunctive Use of Methylphenidate in the Treatment of Psychotic Unipolar Depression","display_name":"Adjunctive Use of Methylphenidate in the Treatment of Psychotic Unipolar Depression","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W1986112802","doi":"https://doi.org/10.1097/wnf.0b013e318157d998","mag":"1986112802","pmid":"https://pubmed.ncbi.nlm.nih.gov/18670250"},"language":"en","primary_location":{"id":"doi:10.1097/wnf.0b013e318157d998","doi":"https://doi.org/10.1097/wnf.0b013e318157d998","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e318157d998","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108616492","display_name":"Chang\u2010Chih Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chang-Chih Huang","raw_affiliation_strings":["Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan","Department of Psychiatry, Tri-Service General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874"]},{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital","institution_ids":["https://openalex.org/I1293718874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022030784","display_name":"I\u2010Shin Shiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"I-Shin Shiah","raw_affiliation_strings":["Department of Psychiatry, Tri-Service General Hospital","National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital","institution_ids":["https://openalex.org/I1293718874"]},{"raw_affiliation_string":"National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001165220","display_name":"Hsing\u2010Kang Chen","orcid":"https://orcid.org/0000-0002-8015-870X","observed_orcids":["https://orcid.org/0000-0002-8015-870X"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hsing-Kang Chen","raw_affiliation_strings":["Department of Psychiatry, Tri-Service General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital","institution_ids":["https://openalex.org/I1293718874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109002655","display_name":"Wei\u2010Chung Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wei-Chung Mao","raw_affiliation_strings":["Department of Psychiatry, Tri-Service General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital","institution_ids":["https://openalex.org/I1293718874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031040023","display_name":"Yi\u2010Wei Yeh","orcid":"https://orcid.org/0000-0001-8690-6206","observed_orcids":["https://orcid.org/0000-0001-8690-6206"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yi-Wei Yeh","raw_affiliation_strings":["Department of Psychiatry, Tri-Service General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital","institution_ids":["https://openalex.org/I1293718874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001165220","https://openalex.org/A5022030784","https://openalex.org/A5031040023","https://openalex.org/A5108616492","https://openalex.org/A5109002655"],"corresponding_institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"],"apc_list":null,"apc_paid":null,"fwci":1.3397,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78645161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"4","first_page":"245","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylphenidate","display_name":"methylphenidate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/melancholic-depression","display_name":"endogenous depression","score":0.906000018119812},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7820000052452087},{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.5429999828338623},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.8859447240829468},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.6318216919898987},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6309158802032471},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5569869875907898},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.47180619835853577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4436691701412201},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.43541571497917175},{"id":"https://openalex.org/C2777330709","wikidata":"https://www.wikidata.org/wiki/Q131543","display_name":"Electroconvulsive therapy","level":3,"score":0.41701942682266235},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.416536808013916},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.38445210456848145},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37073272466659546},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.28472691774368286},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.22619789838790894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20930171012878418},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.101541668176651},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077152","descriptor_name":"Olanzapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/wnf.0b013e318157d998","doi":"https://doi.org/10.1097/wnf.0b013e318157d998","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e318157d998","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:18670250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18670250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropharmacology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W66621154","https://openalex.org/W192950983","https://openalex.org/W1994550766","https://openalex.org/W2001805825","https://openalex.org/W2016046870","https://openalex.org/W2016508442","https://openalex.org/W2032702170","https://openalex.org/W2036047573","https://openalex.org/W2048549144","https://openalex.org/W2064403069","https://openalex.org/W2084442103","https://openalex.org/W2122152981","https://openalex.org/W2205789894","https://openalex.org/W2407652178","https://openalex.org/W2415230744","https://openalex.org/W2433695902"],"related_works":["https://openalex.org/W2092976304","https://openalex.org/W2799705517","https://openalex.org/W2171726146","https://openalex.org/W7045131043","https://openalex.org/W2119698096","https://openalex.org/W3146423580","https://openalex.org/W3085286124","https://openalex.org/W2047522693","https://openalex.org/W2125595726","https://openalex.org/W104522331"],"abstract_inverted_index":{"Adjunctive":[0],"use":[1,49,174,205],"of":[2,36,50,68,119,126,138,175,206,230],"methylphenidate,":[3],"a":[4,11,29,34,124,166,210],"central":[5],"stimulant,":[6],"has":[7],"been":[8],"considered":[9],"as":[10],"potential":[12],"therapeutic":[13,211],"choice":[14],"for":[15,114],"patients":[16,216],"with":[17,85,217],"refractory":[18],"unipolar":[19,38,69,219],"depression,":[20,22,24],"geriatric":[21],"bipolar":[23],"and":[25,59,77,92,144,155,183,191,233],"depression":[26,39,146,220],"secondary":[27],"to":[28,46,98,111,226,242],"medical":[30],"illness.":[31],"We":[32],"present":[33],"case":[35,201],"psychotic":[37,62,218],"in":[40,165,213],"which":[41],"the":[42,47,99,133,172,227],"patient":[43,134],"responded":[44,96],"significantly":[45],"adjunctive":[48,115,173,204],"methylphenidate.":[51,176],"A":[52],"45-year-old":[53],"woman":[54],"had":[55],"melancholic":[56],"depressive":[57],"symptoms":[58],"mood":[60],"incongruent":[61],"features":[63],"during":[64],"her":[65,103,112,141,152],"second":[66],"episode":[67],"depression.":[70],"She":[71,81,150,162],"attempted":[72],"suicide":[73],"by":[74],"hanging":[75],"herself":[76],"was":[78,82,121,130,163,180],"forcibly":[79],"hospitalized.":[80],"initially":[83],"treated":[84],"venlafaxine":[86],"(262.5":[87],"mg/d),":[88,91],"olanzapine":[89],"(20":[90],"benzodiazepines.":[93],"However,":[94],"she":[95,188],"unsatisfactorily":[97],"combination":[100,228],"treatment.":[101],"Because":[102],"family":[104],"refused":[105],"electroconvulsive":[106],"treatment,":[107],"we":[108],"added":[109],"methylphenidate":[110,120,139,179,207],"medications":[113,153],"use.":[116],"The":[117,177],"dose":[118,125],"started":[122],"at":[123,196],"5":[127],"mg/d.":[128],"It":[129],"not":[131,157,223],"until":[132],"received":[135],"30":[136],"mg/d":[137],"that":[140,203],"persistent":[142],"psychosis":[143],"severe":[145],"were":[147],"substantially":[148],"improved.":[149],"tolerated":[151],"well":[154,190],"did":[156],"report":[158],"any":[159],"side":[160],"effects.":[161],"discharged":[164],"stable":[167],"condition":[168],"2":[169],"weeks":[170],"after":[171],"patient's":[178],"gradually":[181],"tapered":[182],"finally":[184],"discontinued.":[185],"To":[186],"date,":[187],"remains":[189],"is":[192],"regularly":[193],"followed":[194],"up":[195],"our":[197],"outpatient":[198],"clinic.":[199],"Our":[200],"suggests":[202],"can":[208],"be":[209],"option":[212],"treating":[214],"some":[215],"who":[221],"do":[222],"adequately":[224],"respond":[225],"treatment":[229],"an":[231,234],"antidepressant":[232],"atypical":[235],"antipsychotic.":[236],"Further":[237],"controlled":[238],"studies":[239],"are":[240],"warranted":[241],"verify":[243],"this.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}