{"id":"https://openalex.org/W1986106546","doi":"https://doi.org/10.1016/0306-3623(93)90174-v","title":"Spinal adenosine modulates capsaicin-induced depressor reflex: Involvement of adenosine A2 receptor","display_name":"Spinal adenosine modulates capsaicin-induced depressor reflex: Involvement of adenosine A2 receptor","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W1986106546","doi":"https://doi.org/10.1016/0306-3623(93)90174-v","mag":"1986106546","pmid":"https://pubmed.ncbi.nlm.nih.gov/7693543"},"language":"en","primary_location":{"id":"doi:10.1016/0306-3623(93)90174-v","doi":"https://doi.org/10.1016/0306-3623(93)90174-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-3623(93)90174-v","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110078621","display_name":"Jwu-Maw Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jwu-Maw Yang","raw_affiliation_strings":["Department of Pharmacology, Kaohsiung Medical College, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Kaohsiung Medical College, Taiwan, R.O.C","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027912422","display_name":"Sheng\u2010Nan Wu","orcid":"https://orcid.org/0000-0002-5208-3253","observed_orcids":["https://orcid.org/0000-0002-5208-3253"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sheng-Nan Wu","raw_affiliation_strings":["Department of Physiology Kaohsiung Medical College, Kaohsiung, Taiwan 80708, R.O.C. [Fax 86-7-321-8309]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology Kaohsiung Medical College, Kaohsiung, Taiwan 80708, R.O.C. [Fax 86-7-321-8309]","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011615090","display_name":"Ing\u2010Jun Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ing-Jun Chen","raw_affiliation_strings":["Department of Pharmacology, Kaohsiung, Taiwan 80708, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Kaohsiung, Taiwan 80708, R.O.C","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.596,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.61198094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"4","first_page":"961","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.2012999951839447,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/depressor-reflex","display_name":"depressor reflex","score":0.9879999756813049},{"id":"https://openalex.org/keywords/adenosine-a2-receptor","display_name":"adenosine A2 receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9369999766349792},{"id":"https://openalex.org/keywords/substance-p-receptor-antagonist","display_name":"substance P antagonist","score":0.7310000061988831},{"id":"https://openalex.org/keywords/afferent-fibers","display_name":"afferent nerve fibers","score":0.7049999833106995},{"id":"https://openalex.org/keywords/substance-p-release","display_name":"substance P release","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cardiovascular-response","display_name":"cardiovascular response","score":0.7129999995231628},{"id":"https://openalex.org/keywords/adenosine-receptor-agonists","display_name":"adenosine receptor agonists","score":0.8180000185966492},{"id":"https://openalex.org/keywords/adenosine-receptor-antagonists","display_name":"adenosine receptor antagonists","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.8424557447433472},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.818808913230896},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7953236103057861},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.6600555181503296},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.6360167264938354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5362588167190552},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5139500498771667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4862481355667114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48509442806243896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4554053246974945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4241715967655182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42151832580566406},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4015936255455017},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.21336564421653748},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.19299927353858948}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-3623(93)90174-v","doi":"https://doi.org/10.1016/0306-3623(93)90174-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-3623(93)90174-v","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},{"id":"pmid:7693543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7693543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1902749214","https://openalex.org/W1914750790","https://openalex.org/W1977592396","https://openalex.org/W1989788293","https://openalex.org/W2015055018","https://openalex.org/W2019867656","https://openalex.org/W2026384693","https://openalex.org/W2040725197","https://openalex.org/W2046845187","https://openalex.org/W2047353693","https://openalex.org/W2049603406","https://openalex.org/W2050730577","https://openalex.org/W2064295865","https://openalex.org/W2064766981","https://openalex.org/W2065392335","https://openalex.org/W2074484901","https://openalex.org/W2075056521","https://openalex.org/W2084673339","https://openalex.org/W2086144893","https://openalex.org/W2088475044","https://openalex.org/W2089007928","https://openalex.org/W2106476906","https://openalex.org/W2109483196","https://openalex.org/W2123370994","https://openalex.org/W2227590791","https://openalex.org/W2246658971","https://openalex.org/W2262211506","https://openalex.org/W2278857123","https://openalex.org/W2319382189","https://openalex.org/W2410376037","https://openalex.org/W2418229467","https://openalex.org/W2502041032","https://openalex.org/W6639968774","https://openalex.org/W6678320287","https://openalex.org/W6694662465"],"related_works":["https://openalex.org/W3176590730","https://openalex.org/W2084673339","https://openalex.org/W2052157292","https://openalex.org/W2044926397","https://openalex.org/W2088291447","https://openalex.org/W2020548112","https://openalex.org/W2407658672","https://openalex.org/W2553582689","https://openalex.org/W4406054930","https://openalex.org/W325998795"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}