{"id":"https://openalex.org/W1986084992","doi":"https://doi.org/10.1093/nar/gkm006","title":"The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase","display_name":"The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase","publication_year":2007,"publication_date":"2007-02-18","ids":{"openalex":"https://openalex.org/W1986084992","doi":"https://doi.org/10.1093/nar/gkm006","mag":"1986084992","pmid":"https://pubmed.ncbi.nlm.nih.gov/17308348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865074"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkm006","doi":"https://doi.org/10.1093/nar/gkm006","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm006","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1624/16760355/gkm006.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/35/5/1624/16760355/gkm006.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029394498","display_name":"Sangeetha Vijayakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangeetha Vijayakumar","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052702979","display_name":"B.R. Chapados","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian R. Chapados","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103099601","display_name":"Kristina Hildegard Schmidt","orcid":"https://orcid.org/0000-0003-1754-5018","observed_orcids":["https://orcid.org/0000-0003-1754-5018"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina H. Schmidt","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081915207","display_name":"Richard David Kolodner","orcid":"https://orcid.org/0000-0002-4806-8384","observed_orcids":["https://orcid.org/0000-0002-4806-8384"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Kolodner","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059713279","display_name":"John A. Tainer","orcid":"https://orcid.org/0000-0003-1659-2429","observed_orcids":["https://orcid.org/0000-0003-1659-2429"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John A. Tainer","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051816777","display_name":"Alan E. Tomkinson","orcid":"https://orcid.org/0000-0002-2671-1711","observed_orcids":["https://orcid.org/0000-0002-2671-1711"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan E. Tomkinson","raw_affiliation_strings":["Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","University of California, San Diego, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA, 2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA and 3 Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"University of California, San Diego, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059713279"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I126744593","https://openalex.org/I36258959","https://openalex.org/I4390039317"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":2.0969,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.86465685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"5","first_page":"1624","last_page":"1637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dna-ligase-i","display_name":"DNA ligase I","score":0.890999972820282},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.6940000057220459},{"id":"https://openalex.org/keywords/co-crystal-structure","display_name":"co-crystal structure","score":0.7300000190734863},{"id":"https://openalex.org/keywords/rfc","display_name":"RFC","score":0.3140000104904175},{"id":"https://openalex.org/keywords/fen1","display_name":"FEN1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8109999895095825},{"id":"https://openalex.org/keywords/okazaki-fragment-processing","display_name":"Okazaki fragment processing","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dna-sliding-clamp","display_name":"DNA sliding clamp","score":0.7310000061988831},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9354828596115112},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.7303276062011719},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5643303990364075},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5463888049125671},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5433022379875183},{"id":"https://openalex.org/C2908738455","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA Ligases","level":4,"score":0.5337311625480652},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.5045269727706909},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4776405394077301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46930745244026184},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.45289507508277893},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.43852734565734863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3835100531578064},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.367728054523468},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3424014449119568},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3356765806674957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32276904582977295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1924477517604828},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072481","descriptor_name":"DNA Ligase ATP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051818","descriptor_name":"Replication Protein C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051818","descriptor_name":"Replication Protein C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkm006","doi":"https://doi.org/10.1093/nar/gkm006","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm006","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1624/16760355/gkm006.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1350849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865074","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1865074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:17308348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17308348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.9860","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.9860","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/35/5/1624.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkm006","doi":"https://doi.org/10.1093/nar/gkm006","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkm006","pdf_url":"https://academic.oup.com/nar/article-pdf/35/5/1624/16760355/gkm006.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1058427504","display_name":"FEN-1 and PCNA Complexes and Human Genome Stability","funder_award_id":"R01CA081967","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1881503854","display_name":null,"funder_award_id":"GM57479","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8166214065","display_name":null,"funder_award_id":"CA081967","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8855306639","display_name":"Roles of DNA Ligase I in Mammalian DNA Metabolism","funder_award_id":"R01GM057479","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000039817","display_name":null,"funder_award_id":"CA92584","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887026","display_name":"Structural Cell Biology of DNA Repair Machines","funder_award_id":"P01CA092584","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914450","display_name":"Enzymology of Mismatch Repair in Yeast","funder_award_id":"R01GM050006","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986084992.pdf","grobid_xml":"https://content.openalex.org/works/W1986084992.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1488848625","https://openalex.org/W1510376578","https://openalex.org/W1552586455","https://openalex.org/W1555441333","https://openalex.org/W1627029737","https://openalex.org/W1916339093","https://openalex.org/W1968760263","https://openalex.org/W1970872037","https://openalex.org/W1982765928","https://openalex.org/W1984197891","https://openalex.org/W1989299971","https://openalex.org/W1989547927","https://openalex.org/W1994245744","https://openalex.org/W1994561103","https://openalex.org/W1995897604","https://openalex.org/W1997002747","https://openalex.org/W2007437374","https://openalex.org/W2009073915","https://openalex.org/W2011681036","https://openalex.org/W2020633581","https://openalex.org/W2021345772","https://openalex.org/W2022910177","https://openalex.org/W2027978582","https://openalex.org/W2031504305","https://openalex.org/W2034746516","https://openalex.org/W2035018601","https://openalex.org/W2045067920","https://openalex.org/W2049528447","https://openalex.org/W2051555627","https://openalex.org/W2053133441","https://openalex.org/W2057840174","https://openalex.org/W2060262536","https://openalex.org/W2062143483","https://openalex.org/W2065014822","https://openalex.org/W2071830497","https://openalex.org/W2076554477","https://openalex.org/W2078678509","https://openalex.org/W2084798490","https://openalex.org/W2088867782","https://openalex.org/W2090903262","https://openalex.org/W2099458703","https://openalex.org/W2107935862","https://openalex.org/W2109263298","https://openalex.org/W2112200653","https://openalex.org/W2116537286","https://openalex.org/W2117538545","https://openalex.org/W2120143131","https://openalex.org/W2122748184","https://openalex.org/W2123985521","https://openalex.org/W2124919704","https://openalex.org/W2126365697","https://openalex.org/W2126856425","https://openalex.org/W2135158692","https://openalex.org/W2135839939","https://openalex.org/W2159531864","https://openalex.org/W2159569801","https://openalex.org/W2164246004","https://openalex.org/W2165181073","https://openalex.org/W2166903547","https://openalex.org/W2170380264","https://openalex.org/W4254120696"],"related_works":["https://openalex.org/W2088867782","https://openalex.org/W2076554477","https://openalex.org/W2591024586","https://openalex.org/W11787195","https://openalex.org/W2063995526","https://openalex.org/W2001890566","https://openalex.org/W2020633581","https://openalex.org/W1993073412","https://openalex.org/W2159569801","https://openalex.org/W2095236231"],"abstract_inverted_index":{"There":[0],"is":[1,105,149],"compelling":[2],"evidence":[3],"that":[4,86,138,197],"proliferating":[5],"cell":[6],"nuclear":[7],"antigen":[8],"(PCNA),":[9],"a":[10,27,49],"DNA":[11,24,60,101,124],"sliding":[12],"clamp,":[13],"co-ordinates":[14],"the":[15,42,52,68,76,98,112,127,139,153,156,166,170,175,186,193,201],"processing":[16],"and":[17,73,82,102,121,155,180,182,190],"joining":[18],"of":[19,31,45,57,78,100,129,141,147,160,169,178,188,205],"Okazaki":[20],"fragments":[21],"during":[22],"eukaryotic":[23],"replication.":[25],"However,":[26],"detailed":[28],"mechanistic":[29],"understanding":[30],"functional":[32,167],"PCNA:ligase":[33],"I":[34],"interactions":[35,187],"has":[36],"been":[37],"incomplete.":[38],"Here":[39,135],"we":[40,136],"present":[41],"co-crystal":[43],"structure":[44,172],"yeast":[46,59,117],"PCNA":[47,54,104,130,142,179,195],"with":[48,120,192],"peptide":[50,65],"encompassing":[51],"conserved":[53],"interaction":[55,89,158],"motif":[56],"Cdc9,":[58],"ligase":[61,125],"I.":[62],"The":[63],"Cdc9":[64,123,148,181,191],"contacts":[66],"both":[67,96,152],"inter-domain":[69],"connector":[70],"loop":[71],"(IDCL)":[72],"residues":[74],"near":[75],"C-terminus":[77],"PCNA.":[79,161],"Complementary":[80],"mutational":[81],"biochemical":[83],"results":[84,164],"demonstrate":[85,165],"these":[87,163,206],"two":[88,194],"interfaces":[90,159,196],"are":[91],"required":[92],"for":[93],"complex":[94],"formation":[95],"in":[97,185],"absence":[99],"when":[103],"topologically":[106],"linked":[107],"to":[108,111,143,200],"DNA.":[109],"Similar":[110],"functionally":[113],"homologous":[114],"human":[115],"proteins,":[116],"RFC":[118],"interacts":[119],"inhibits":[122],"whereas":[126],"addition":[128],"alleviates":[131],"inhibition":[132,146],"by":[133],"RFC.":[134],"show":[137],"ability":[140],"overcome":[144],"RFC-mediated":[145],"dependent":[150],"upon":[151],"IDCL":[154],"C-terminal":[157,176],"Together":[162],"significance":[168],"beta-zipper":[171],"formed":[173],"between":[174],"domain":[177],"reveal":[183],"differences":[184],"FEN-1":[189],"may":[198],"contribute":[199],"co-ordinated,":[202],"sequential":[203],"action":[204],"enzymes.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
