{"id":"https://openalex.org/W1986010852","doi":"https://doi.org/10.1016/j.toxlet.2011.05.1034","title":"Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor","display_name":"Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor","publication_year":2011,"publication_date":"2011-06-05","ids":{"openalex":"https://openalex.org/W1986010852","doi":"https://doi.org/10.1016/j.toxlet.2011.05.1034","mag":"1986010852","pmid":"https://pubmed.ncbi.nlm.nih.gov/21641981"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2011.05.1034","doi":"https://doi.org/10.1016/j.toxlet.2011.05.1034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2011.05.1034","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060913161","display_name":"Marcin Ratajewski","orcid":"https://orcid.org/0000-0001-5391-5843","observed_orcids":["https://orcid.org/0000-0001-5391-5843"]},"institutions":[{"id":"https://openalex.org/I4210124861","display_name":"Institute for Medical Biology","ror":"https://ror.org/02kstzn75","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Ratajewski","raw_affiliation_strings":["Laboratory of Transcriptional Regulation, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Transcriptional Regulation, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland","institution_ids":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072408263","display_name":"Aurelia Walczak\u2010Drzewiecka","orcid":"https://orcid.org/0000-0001-9519-8774","observed_orcids":["https://orcid.org/0000-0001-9519-8774"]},"institutions":[{"id":"https://openalex.org/I4210124861","display_name":"Institute for Medical Biology","ror":"https://ror.org/02kstzn75","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aurelia Walczak-Drzewiecka","raw_affiliation_strings":["Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland","institution_ids":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050282535","display_name":"Anna Sa\u0142kowska","orcid":"https://orcid.org/0000-0002-3607-2888","observed_orcids":["https://orcid.org/0000-0002-3607-2888"]},"institutions":[{"id":"https://openalex.org/I4210124861","display_name":"Institute for Medical Biology","ror":"https://ror.org/02kstzn75","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Sa\u0142kowska","raw_affiliation_strings":["Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland","institution_ids":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047892706","display_name":"Jaros\u0142aw Dastych","orcid":"https://orcid.org/0000-0001-9102-2261","observed_orcids":["https://orcid.org/0000-0001-9102-2261"]},"institutions":[{"id":"https://openalex.org/I4210124861","display_name":"Institute for Medical Biology","ror":"https://ror.org/02kstzn75","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jaros\u0142aw Dastych","raw_affiliation_strings":["Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland","institution_ids":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047892706"],"corresponding_institution_ids":["https://openalex.org/I4210124861","https://openalex.org/I99542240"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":3.7778,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92159482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"205","issue":"2","first_page":"146","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aflatoxins","display_name":"aflatoxins","score":0.8700000047683716},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.8529999852180481},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.6669999957084656},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.5189999938011169},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.6990000009536743},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.9792733788490295},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.653990626335144},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6222959160804749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5887879729270935},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5822558403015137},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5640356540679932},{"id":"https://openalex.org/C193264327","wikidata":"https://www.wikidata.org/wiki/Q14905078","display_name":"Constitutive androstane receptor","level":5,"score":0.556736171245575},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.5425040125846863},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4801706373691559},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4390346109867096},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4250173568725586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4245315194129944},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42335978150367737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3516188859939575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29369282722473145},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.21634137630462646},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2074565589427948},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05519971251487732}],"mesh":[{"descriptor_ui":"D000077297","descriptor_name":"Pregnane X Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2011.05.1034","doi":"https://doi.org/10.1016/j.toxlet.2011.05.1034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2011.05.1034","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:21641981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21641981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335197","display_name":"Norway Grants","ror":"https://ror.org/02dfxg175"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1215325098","https://openalex.org/W1577577364","https://openalex.org/W1802360514","https://openalex.org/W1917241220","https://openalex.org/W1964066906","https://openalex.org/W1972996926","https://openalex.org/W1978160817","https://openalex.org/W1981629940","https://openalex.org/W1981873124","https://openalex.org/W1985909253","https://openalex.org/W1988877872","https://openalex.org/W1990077514","https://openalex.org/W2001619915","https://openalex.org/W2003780406","https://openalex.org/W2004117462","https://openalex.org/W2005026027","https://openalex.org/W2006794523","https://openalex.org/W2009838390","https://openalex.org/W2010519104","https://openalex.org/W2013147737","https://openalex.org/W2019349841","https://openalex.org/W2021444563","https://openalex.org/W2026819280","https://openalex.org/W2048449797","https://openalex.org/W2057223282","https://openalex.org/W2063203910","https://openalex.org/W2066286039","https://openalex.org/W2072634355","https://openalex.org/W2073637647","https://openalex.org/W2074141218","https://openalex.org/W2076413023","https://openalex.org/W2080255198","https://openalex.org/W2084462922","https://openalex.org/W2089174518","https://openalex.org/W2096561521","https://openalex.org/W2097926865","https://openalex.org/W2101314083","https://openalex.org/W2106102436","https://openalex.org/W2108107134","https://openalex.org/W2108270923","https://openalex.org/W2112589546","https://openalex.org/W2123331629","https://openalex.org/W2128372344","https://openalex.org/W2130886489","https://openalex.org/W2133954410","https://openalex.org/W2134567873","https://openalex.org/W2142244531","https://openalex.org/W2146544786","https://openalex.org/W2149038504","https://openalex.org/W2149044745","https://openalex.org/W2149567003","https://openalex.org/W2150988649","https://openalex.org/W2154015838","https://openalex.org/W2154929692","https://openalex.org/W2155228806","https://openalex.org/W2156142697","https://openalex.org/W2157497123","https://openalex.org/W2157906581","https://openalex.org/W2159312550","https://openalex.org/W2161816485","https://openalex.org/W2165248513","https://openalex.org/W2167383256","https://openalex.org/W2331014325","https://openalex.org/W4211237594","https://openalex.org/W4252021281","https://openalex.org/W6638157926","https://openalex.org/W6668591573","https://openalex.org/W6676684457"],"related_works":["https://openalex.org/W2076413023","https://openalex.org/W2056975261","https://openalex.org/W7096883446","https://openalex.org/W1675774621","https://openalex.org/W1749119508","https://openalex.org/W1966855778","https://openalex.org/W1994433522","https://openalex.org/W2082640895","https://openalex.org/W2160450046","https://openalex.org/W2031555815"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}