{"id":"https://openalex.org/W1986010069","doi":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","title":"New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer","display_name":"New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1986010069","doi":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","mag":"1986010069","pmid":"https://pubmed.ncbi.nlm.nih.gov/11004678"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820001015%2988%3A2%3C260%3A%3AAID-IJC18%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820001015%2988%3A2%3C260%3A%3AAID-IJC18%3E3.0.CO%3B2-Q","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005170300","display_name":"Annemarie H. van Hattum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Annemarie H. Van Hattum","raw_affiliation_strings":["Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105878379","display_name":"Herbert M. Pinedo","orcid":"https://orcid.org/0000-0002-8980-371X","observed_orcids":["https://orcid.org/0000-0002-8980-371X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Herbert M. Pinedo","raw_affiliation_strings":["Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111812290","display_name":"Hennie M.M. Schl\u00fcper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hennie M.M. Schl\u00fcper","raw_affiliation_strings":["Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109866614","display_name":"Frederick H. Hausheer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126566","display_name":"BioNumerik (United States)","ror":"https://ror.org/02yq66p71","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick H. Hausheer","raw_affiliation_strings":["BioNumerik Pharmaceuticals, Inc., San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioNumerik Pharmaceuticals, Inc., San Antonio, Texas, USA","institution_ids":["https://openalex.org/I4210126566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088663155","display_name":"Epie Boven","orcid":"https://orcid.org/0000-0001-9287-743X","observed_orcids":["https://orcid.org/0000-0001-9287-743X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Epie Boven","raw_affiliation_strings":["Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088663155"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.444,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.80130326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"88","issue":"2","first_page":"260","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camptothecin-derivatives","display_name":"camptothecin derivatives","score":0.9229999780654907},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mrp","display_name":"MRP","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lrp","display_name":"LRP","score":0.8259999752044678},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6460000276565552},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lipophilic-drugs","display_name":"lipophilic drugs","score":0.5270000100135803},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.656000018119812},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.550000011920929},{"id":"https://openalex.org/keywords/silicon-compounds","display_name":"silicon compounds","score":0.38999998569488525},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.9155656099319458},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6849737763404846},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.650729775428772},{"id":"https://openalex.org/C2780508388","wikidata":"https://www.wikidata.org/wiki/Q1750127","display_name":"SN-38","level":5,"score":0.5601734519004822},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5567107200622559},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.51617032289505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5032755732536316},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48402994871139526},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4625856578350067},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.4461890459060669},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43631216883659363},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.4344688057899475},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.42986243963241577},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4150574505329132},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4057977795600891},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.38213154673576355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3033721148967743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21559450030326843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21233072876930237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14096051454544067},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820001015%2988%3A2%3C260%3A%3AAID-IJC18%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11004678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11004678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820001015%2988%3A2%3C260%3A%3AAID-IJC18%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986010069.pdf","grobid_xml":"https://content.openalex.org/works/W1986010069.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W37120966","https://openalex.org/W1505903173","https://openalex.org/W1631493806","https://openalex.org/W1774923611","https://openalex.org/W1850727413","https://openalex.org/W1886830245","https://openalex.org/W2001096578","https://openalex.org/W2016110604","https://openalex.org/W2016722642","https://openalex.org/W2018185888","https://openalex.org/W2049235080","https://openalex.org/W2054901630","https://openalex.org/W2059224614","https://openalex.org/W2088817932","https://openalex.org/W2092998745","https://openalex.org/W2102345056","https://openalex.org/W2125205754","https://openalex.org/W2127819051","https://openalex.org/W2143863165","https://openalex.org/W2145383415","https://openalex.org/W2152326762","https://openalex.org/W2161663775","https://openalex.org/W2168070336","https://openalex.org/W2341113379","https://openalex.org/W2400411938","https://openalex.org/W2411335863","https://openalex.org/W2435550146"],"related_works":["https://openalex.org/W1980183760","https://openalex.org/W3038215138","https://openalex.org/W1980521536","https://openalex.org/W3080095163","https://openalex.org/W1595572859","https://openalex.org/W2573480279","https://openalex.org/W1969972386","https://openalex.org/W3007320830","https://openalex.org/W2320048043","https://openalex.org/W1968819069"],"abstract_inverted_index":{"BNP1350,":[0,247],"7-[(2-trimethylsilyl)ethyl]-20(S)-camptothecin,":[1],"is":[2,286],"a":[3,62,276,287],"novel":[4],"semi-synthetic,":[5],"highly":[6],"lipophilic,":[7],"silicon-containing":[8],"camptothecin":[9],"and":[10,33,50,68,95,133,162,201,203,211,251,285],"an":[11],"inhibitor":[12],"of":[13,43,57,65,73,80,111,137,217,228,270,279,293],"topoisomerase":[14],"I.":[15],"It":[16],"has":[17],"been":[18],"supercomputer":[19],"engineered":[20],"for":[21,221,290],"superior":[22,25],"oral":[23,291],"bioavailability,":[24],"lactone":[26],"stability,":[27],"broad":[28,277],"anti-tumor":[29,53],"activity,":[30],"increased":[31],"potency":[32],"insensitivity":[34],"to":[35],"Pgp/MRP/LRP":[36],"drug":[37],"resistance.":[38],"We":[39,59],"determined":[40,61],"the":[41,71,81,135,204,229,268],"efficacy":[42,72,269],"BNP1350":[44,98,123,138,149,222,233,274],"in":[45,76,89,142,146,173,185,196,225,249,256,258,281],"experimental":[46,282],"human":[47,178,283],"colon":[48,91,186],"cancer":[49,92,187,209],"compared":[51],"its":[52],"effects":[54],"with":[55,114],"those":[56],"CPT-11/SN-38.":[58],"also":[60],"possible":[63],"influence":[64,266],"Pgp,":[66,117],"MRP":[67,118],"LRP":[69,120],"on":[70,267],"BNP1350.":[74,271],"The":[75,181],"vitro":[77],"anti-proliferative":[78],"capacity":[79],"compounds":[82],"using":[83],"various":[84],"exposure":[85],"times":[86],"was":[87,99,124,139,150,219,234,243,263],"assessed":[88],"five":[90],"cell":[93,109],"lines":[94,110],"indicated":[96],"that":[97,122,134,261],"similarly":[100,235],"effective":[101,127,236,245],"or":[102,155,191,240],"slightly":[103],"more":[104,126],"potent":[105],"than":[106,128],"SN-38.":[107],"Four":[108],"other":[112],"origin":[113],"sublines":[115],"expressing":[116],"and/or":[119],"showed":[121],"significantly":[125],"SN-38":[129],"(p":[130],"<":[131],"0.05)":[132],"activity":[136,280],"not":[140],"reduced":[141],"multidrug-resistant":[143],"cells.":[144],"For":[145],"vivo":[147,259],"experiments,":[148],"given":[151,223,238],"1.0":[152],"mg/kg":[153,157,165],"i.p.":[154,166,224,239],"1.5":[156],"p.o.":[158,241],"daily":[159,167],"x":[160,168],"5":[161,169],"CPT-11":[163,242],"20":[164],"being":[170],"equitoxic":[171],"schedules":[172,182],"nude":[174],"mice":[175],"bearing":[176],"s.c.":[177],"tumor":[179],"xenografts.":[180,214,253],"were":[183],"studied":[184],"xenografts":[188,199,210,231,257],"COLO320,":[189],"COLO205":[190],"WiDr":[192],"as":[193,195,244,246],"well":[194],"two":[197],"Pgp-positive":[198],"2780AD":[200],"BRO/mdr1.1":[202,252],"parental":[205],"Pgp-negative":[206],"A2780":[207],"ovarian":[208],"BRO":[212,250],"melanoma":[213],"Growth":[215],"inhibition":[216],">50%":[218],"obtained":[220],"six":[226],"out":[227],"seven":[230],"studied.":[232],"when":[237],"except":[248],"Pgp":[254],"expression":[255],"confirmed":[260],"there":[262],"no":[264],"negative":[265],"In":[272],"conclusion,":[273],"shows":[275],"spectrum":[278],"tumors":[284],"suitable":[288],"candidate":[289],"treatment":[292],"cancer.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}