{"id":"https://openalex.org/W1986009186","doi":"https://doi.org/10.3389/fendo.2013.00179","title":"Quantitative Analysis of Neurotransmitter Pathways Under Steady State Conditions \u2013 A Perspective","display_name":"Quantitative Analysis of Neurotransmitter Pathways Under Steady State Conditions \u2013 A Perspective","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1986009186","doi":"https://doi.org/10.3389/fendo.2013.00179","mag":"1986009186","pmid":"https://pubmed.ncbi.nlm.nih.gov/24302920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3831341"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2013.00179","doi":"https://doi.org/10.3389/fendo.2013.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00179/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00179/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051052158","display_name":"Arthur J.L. Cooper","orcid":"https://orcid.org/0000-0002-9143-8504","observed_orcids":["https://orcid.org/0000-0002-9143-8504"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur J. L. Cooper","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, New York Medical College , Valhalla, NY , USA","New York Medical College, Biochemistry and Molecular Biology, 15 Dana Road, Valhalla, 10595, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, New York Medical College , Valhalla, NY , USA","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"New York Medical College, Biochemistry and Molecular Biology, 15 Dana Road, Valhalla, 10595, New York, United States","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051052158"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.1858,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.10989011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"4","issue":null,"first_page":"179","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotransmitter-pathways","display_name":"neurotransmitter pathways","score":0.8999999761581421},{"id":"https://openalex.org/keywords/glutamate-glutamine-cycle","display_name":"glutamate-glutamine cycle","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.5109999775886536},{"id":"https://openalex.org/keywords/compartmental-modeling","display_name":"compartmental modeling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5130000114440918},{"id":"https://openalex.org/keywords/blood-ammonia","display_name":"blood ammonia","score":0.6010000109672546},{"id":"https://openalex.org/keywords/urea-cycle-disorders","display_name":"urea cycle disorders","score":0.8840000033378601},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.6491219401359558},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6327614188194275},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5082297325134277},{"id":"https://openalex.org/C2910715078","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter Agents","level":4,"score":0.438204288482666},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3310595452785492},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32002925872802734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30090704560279846},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16252395510673523},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10022473335266113}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fendo.2013.00179","doi":"https://doi.org/10.3389/fendo.2013.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00179/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2832632","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3831341","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3831341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3831341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:24302920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24302920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-1043","doi":null,"is_oa":true,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/43","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-6742","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/5813","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6ea5dc2f58464b26b3fc7650d4a4c4c0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6ea5dc2f58464b26b3fc7650d4a4c4c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 4 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2013.00179","doi":"https://doi.org/10.3389/fendo.2013.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00179/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7143638365","display_name":"PATHOGENESIS OF HEPATIC COMA","funder_award_id":"R01DK016739","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1986009186.pdf","grobid_xml":"https://content.openalex.org/works/W1986009186.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W202004645","https://openalex.org/W240309487","https://openalex.org/W1026634013","https://openalex.org/W1586388232","https://openalex.org/W1592565027","https://openalex.org/W1800127113","https://openalex.org/W1930183105","https://openalex.org/W1942398216","https://openalex.org/W1968322702","https://openalex.org/W1968807182","https://openalex.org/W1970693253","https://openalex.org/W1975393539","https://openalex.org/W1976456720","https://openalex.org/W1977683030","https://openalex.org/W1983337090","https://openalex.org/W1984089779","https://openalex.org/W1985335404","https://openalex.org/W1986917708","https://openalex.org/W1987080089","https://openalex.org/W1988964176","https://openalex.org/W1991316313","https://openalex.org/W2000639563","https://openalex.org/W2011859165","https://openalex.org/W2019990419","https://openalex.org/W2022059331","https://openalex.org/W2032163981","https://openalex.org/W2035287261","https://openalex.org/W2038689269","https://openalex.org/W2043305007","https://openalex.org/W2045209911","https://openalex.org/W2046185916","https://openalex.org/W2052750469","https://openalex.org/W2054499684","https://openalex.org/W2061534302","https://openalex.org/W2077187035","https://openalex.org/W2079930410","https://openalex.org/W2087245233","https://openalex.org/W2094633173","https://openalex.org/W2094633691","https://openalex.org/W2096597598","https://openalex.org/W2098371519","https://openalex.org/W2113413893","https://openalex.org/W2124366134","https://openalex.org/W2138266626","https://openalex.org/W2160396234","https://openalex.org/W2160604250","https://openalex.org/W2183452160","https://openalex.org/W2184186366","https://openalex.org/W2315074494","https://openalex.org/W2327802890","https://openalex.org/W6959456255"],"related_works":["https://openalex.org/W170825154","https://openalex.org/W2138266626","https://openalex.org/W1949132276","https://openalex.org/W1497578315","https://openalex.org/W1964052519","https://openalex.org/W2064898829","https://openalex.org/W1648461994","https://openalex.org/W2947996391","https://openalex.org/W1992521533","https://openalex.org/W173633881"],"abstract_inverted_index":{"In":[0],"a":[1,14,75,91,109],"contribution":[2],"to":[3],"this":[4],"Research":[5],"Topic":[6],"Erkki":[7],"Somersalo":[8,103],"and":[9,35,55,97,104,116],"Daniela":[10],"Calvetti":[11,105],"carried":[12],"out":[13],"mathematical":[15],"analysis":[16,40],"of":[17,58,68,80,83,87,94,102,114],"neurotransmitter":[18],"pathways":[19],"in":[20,49,65],"brain,":[21],"modeling":[22],"compartmental":[23],"nitrogen":[24,45,88],"flux":[25],"among":[26],"several":[27],"major":[28],"participants":[29],"-":[30,90],"ammonia,":[31,70],"glutamine,":[32],"glutamate,":[33],"GABA,":[34],"selected":[36],"amino":[37],"acids.":[38],"This":[39],"is":[41,47,72,78,106],"important":[42],"because":[43],"cerebral":[44,84,95,118],"metabolism":[46,89],"perturbed":[48],"many":[50],"diseases,":[51],"including":[52],"liver":[53],"disease":[54],"inborn":[56],"errors":[57],"the":[59,81],"urea":[60],"cycle.":[61],"These":[62],"diseases":[63],"result":[64],"an":[66],"elevation":[67],"blood":[69],"which":[71],"neurotoxic.":[73],"Here,":[74],"brief":[76],"description":[77],"provided":[79],"discovery":[82],"metabolic":[85],"compartmentation":[86],"key":[92],"feature":[93],"glutamate-glutamine":[96],"GABA-glutamine":[98],"cycles.":[99],"The":[100],"work":[101],"discussed":[107],"as":[108],"model":[110],"for":[111],"future":[112],"studies":[113],"normal":[115],"pathological":[117],"ammonia":[119],"metabolism.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}